ABHelix
Here we will discuss how to process BCR cDNA libraries obtained with ABHelix kit.
Data libraries
This tutorial uses the data from the following publication: High frequency of shared clonotypes in human B cell receptor repertoires. Soto C et al., , Nature, 2019 Feb;566(7744):398-402 doi: 10.1038/s41586-019-0934-8
Peripheral blood samples were collected from three donors : HIP1 (female, 47 y.o.), HIP2 (male, 22 y.o.) and HIP3(male, 29 y.o.). Samples were collected in multiple replicas. Total RNA was extracted from PBMCs and multiple reactions of reverse transcription were combined and purified using magnetic beads. The purified RT products were divided evenly for the first round of PCR amplification specific to human IgG, IgL IgK, IgM, or IgA. The 5' multiplex PCR primers anneal within the leader sequences of each productive V gene and the 3' primers within the constant regions, but in close approximation to the J gene/constant region junctions. The resulting first-round PCR products were purified with magnetic beads and subjected to the second round of PCR amplification to add Illumina index and adapter sequences. Subsequent amplicon libraries were sequenced using next-generation sequencing. Paired end sequencing was performed on Illumina HiSeq 2500, R1 and R2 are 250bp long.
All data is available from SRA (PRJNA511481) using e.g. SRA Explorer.
Use aria2c for efficient download of the full dataset with the proper filenames:
download.sh
mkdir -p raw
aria2c -c -s 16 -x 16 -k 1M -j 8 -i download-list.txt
download-list.txt
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365277/SRR8365277_1.fastq.gz
out=raw/SRR8365277_HIP1_female_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365278/SRR8365278_1.fastq.gz
out=raw/SRR8365278_HIP1_female_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365279/SRR8365279_1.fastq.gz
out=raw/SRR8365279_HIP1_female_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365280/SRR8365280_1.fastq.gz
out=raw/SRR8365280_HIP1_female_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365281/SRR8365281_1.fastq.gz
out=raw/SRR8365281_HIP1_female_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365282/SRR8365282_1.fastq.gz
out=raw/SRR8365282_HIP1_female_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365283/SRR8365283_1.fastq.gz
out=raw/SRR8365283_HIP1_female_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365284/SRR8365284_1.fastq.gz
out=raw/SRR8365284_HIP1_female_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365285/SRR8365285_1.fastq.gz
out=raw/SRR8365285_HIP2_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365286/SRR8365286_1.fastq.gz
out=raw/SRR8365286_HIP2_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365287/SRR8365287_1.fastq.gz
out=raw/SRR8365287_HIP2_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365288/SRR8365288_1.fastq.gz
out=raw/SRR8365288_HIP2_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365289/SRR8365289_1.fastq.gz
out=raw/SRR8365289_HIP2_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365290/SRR8365290_1.fastq.gz
out=raw/SRR8365290_HIP2_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365291/SRR8365291_1.fastq.gz
out=raw/SRR8365291_HIP2_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365292/SRR8365292_1.fastq.gz
out=raw/SRR8365292_HIP2_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365293/SRR8365293_1.fastq.gz
out=raw/SRR8365293_HIP3_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365294/SRR8365294_1.fastq.gz
out=raw/SRR8365294_HIP3_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365295/SRR8365295_1.fastq.gz
out=raw/SRR8365295_HIP3_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365296/SRR8365296_1.fastq.gz
out=raw/SRR8365296_HIP3_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365297/SRR8365297_1.fastq.gz
out=raw/SRR8365297_HIP2_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365298/SRR8365298_1.fastq.gz
out=raw/SRR8365298_HIP2_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365299/SRR8365299_1.fastq.gz
out=raw/SRR8365299_HIP3_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365300/SRR8365300_1.fastq.gz
out=raw/SRR8365300_HIP3_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365311/SRR8365311_1.fastq.gz
out=raw/SRR8365311_HIP1_female_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365312/SRR8365312_1.fastq.gz
out=raw/SRR8365312_HIP1_female_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365313/SRR8365313_1.fastq.gz
out=raw/SRR8365313_HIP1_female_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365314/SRR8365314_1.fastq.gz
out=raw/SRR8365314_HIP1_female_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365315/SRR8365315_1.fastq.gz
out=raw/SRR8365315_HIP1_female_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365316/SRR8365316_1.fastq.gz
out=raw/SRR8365316_HIP1_female_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365317/SRR8365317_1.fastq.gz
out=raw/SRR8365317_HIP1_female_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365318/SRR8365318_1.fastq.gz
out=raw/SRR8365318_HIP1_female_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365319/SRR8365319_1.fastq.gz
out=raw/SRR8365319_HIP1_female_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365320/SRR8365320_1.fastq.gz
out=raw/SRR8365320_HIP1_female_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365323/SRR8365323_1.fastq.gz
out=raw/SRR8365323_HIP3_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365332/SRR8365332_1.fastq.gz
out=raw/SRR8365332_HIP2_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365333/SRR8365333_1.fastq.gz
out=raw/SRR8365333_HIP2_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365334/SRR8365334_1.fastq.gz
out=raw/SRR8365334_HIP2_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365335/SRR8365335_1.fastq.gz
out=raw/SRR8365335_HIP2_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365336/SRR8365336_1.fastq.gz
out=raw/SRR8365336_HIP2_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365337/SRR8365337_1.fastq.gz
out=raw/SRR8365337_HIP2_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365338/SRR8365338_1.fastq.gz
out=raw/SRR8365338_HIP2_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365339/SRR8365339_1.fastq.gz
out=raw/SRR8365339_HIP2_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365340/SRR8365340_1.fastq.gz
out=raw/SRR8365340_HIP3_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365341/SRR8365341_1.fastq.gz
out=raw/SRR8365341_HIP3_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365342/SRR8365342_1.fastq.gz
out=raw/SRR8365342_HIP2_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365343/SRR8365343_1.fastq.gz
out=raw/SRR8365343_HIP2_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365344/SRR8365344_1.fastq.gz
out=raw/SRR8365344_HIP3_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365345/SRR8365345_1.fastq.gz
out=raw/SRR8365345_HIP3_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365346/SRR8365346_1.fastq.gz
out=raw/SRR8365346_HIP3_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365347/SRR8365347_1.fastq.gz
out=raw/SRR8365347_HIP3_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365349/SRR8365349_1.fastq.gz
out=raw/SRR8365349_HIP2_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365350/SRR8365350_1.fastq.gz
out=raw/SRR8365350_HIP2_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365351/SRR8365351_1.fastq.gz
out=raw/SRR8365351_HIP2_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365352/SRR8365352_1.fastq.gz
out=raw/SRR8365352_HIP2_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365353/SRR8365353_1.fastq.gz
out=raw/SRR8365353_HIP2_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365354/SRR8365354_1.fastq.gz
out=raw/SRR8365354_HIP2_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365355/SRR8365355_1.fastq.gz
out=raw/SRR8365355_HIP2_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365356/SRR8365356_1.fastq.gz
out=raw/SRR8365356_HIP2_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365357/SRR8365357_1.fastq.gz
out=raw/SRR8365357_HIP2_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365358/SRR8365358_1.fastq.gz
out=raw/SRR8365358_HIP2_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365359/SRR8365359_1.fastq.gz
out=raw/SRR8365359_HIP3_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365360/SRR8365360_1.fastq.gz
out=raw/SRR8365360_HIP3_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365361/SRR8365361_1.fastq.gz
out=raw/SRR8365361_HIP3_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365362/SRR8365362_1.fastq.gz
out=raw/SRR8365362_HIP3_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365363/SRR8365363_1.fastq.gz
out=raw/SRR8365363_HIP3_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365364/SRR8365364_1.fastq.gz
out=raw/SRR8365364_HIP3_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365365/SRR8365365_1.fastq.gz
out=raw/SRR8365365_HIP3_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365366/SRR8365366_1.fastq.gz
out=raw/SRR8365366_HIP3_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365367/SRR8365367_1.fastq.gz
out=raw/SRR8365367_HIP3_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365368/SRR8365368_1.fastq.gz
out=raw/SRR8365368_HIP3_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365369/SRR8365369_1.fastq.gz
out=raw/SRR8365369_HIP3_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365370/SRR8365370_1.fastq.gz
out=raw/SRR8365370_HIP2_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365371/SRR8365371_1.fastq.gz
out=raw/SRR8365371_HIP2_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365372/SRR8365372_1.fastq.gz
out=raw/SRR8365372_HIP3_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365373/SRR8365373_1.fastq.gz
out=raw/SRR8365373_HIP2_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365374/SRR8365374_1.fastq.gz
out=raw/SRR8365374_HIP2_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365375/SRR8365375_1.fastq.gz
out=raw/SRR8365375_HIP2_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365376/SRR8365376_1.fastq.gz
out=raw/SRR8365376_HIP2_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365377/SRR8365377_1.fastq.gz
out=raw/SRR8365377_HIP2_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365378/SRR8365378_1.fastq.gz
out=raw/SRR8365378_HIP2_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365379/SRR8365379_1.fastq.gz
out=raw/SRR8365379_HIP2_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365380/SRR8365380_1.fastq.gz
out=raw/SRR8365380_HIP2_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365381/SRR8365381_1.fastq.gz
out=raw/SRR8365381_HIP3_male_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365382/SRR8365382_1.fastq.gz
out=raw/SRR8365382_HIP3_male_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365383/SRR8365383_1.fastq.gz
out=raw/SRR8365383_HIP3_male_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365384/SRR8365384_1.fastq.gz
out=raw/SRR8365384_HIP3_male_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365385/SRR8365385_1.fastq.gz
out=raw/SRR8365385_HIP3_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365386/SRR8365386_1.fastq.gz
out=raw/SRR8365386_HIP3_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365387/SRR8365387_1.fastq.gz
out=raw/SRR8365387_HIP3_male_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365388/SRR8365388_1.fastq.gz
out=raw/SRR8365388_HIP3_male_IgM_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365389/SRR8365389_1.fastq.gz
out=raw/SRR8365389_HIP3_male_IgA_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365390/SRR8365390_1.fastq.gz
out=raw/SRR8365390_HIP3_male_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365391/SRR8365391_1.fastq.gz
out=raw/SRR8365391_HIP1_female_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365392/SRR8365392_1.fastq.gz
out=raw/SRR8365392_HIP1_female_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365393/SRR8365393_1.fastq.gz
out=raw/SRR8365393_HIP1_female_IgG3_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365394/SRR8365394_1.fastq.gz
out=raw/SRR8365394_HIP1_female_IgG4_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365395/SRR8365395_1.fastq.gz
out=raw/SRR8365395_HIP1_female_IgG1_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365396/SRR8365396_1.fastq.gz
out=raw/SRR8365396_HIP1_female_IgG2_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365397/SRR8365397_1.fastq.gz
out=raw/SRR8365397_HIP1_female_IgK_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365398/SRR8365398_1.fastq.gz
out=raw/SRR8365398_HIP1_female_IgL_R1.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365399/SRR8365399_1.fastq.gz
out=raw/SRR8365399_HIP1_female_IgM_R1.fastq.gz
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out=raw/SRR8365368_HIP3_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365369/SRR8365369_2.fastq.gz
out=raw/SRR8365369_HIP3_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365370/SRR8365370_2.fastq.gz
out=raw/SRR8365370_HIP2_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365371/SRR8365371_2.fastq.gz
out=raw/SRR8365371_HIP2_male_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365372/SRR8365372_2.fastq.gz
out=raw/SRR8365372_HIP3_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365373/SRR8365373_2.fastq.gz
out=raw/SRR8365373_HIP2_male_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365374/SRR8365374_2.fastq.gz
out=raw/SRR8365374_HIP2_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365375/SRR8365375_2.fastq.gz
out=raw/SRR8365375_HIP2_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365376/SRR8365376_2.fastq.gz
out=raw/SRR8365376_HIP2_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365377/SRR8365377_2.fastq.gz
out=raw/SRR8365377_HIP2_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365378/SRR8365378_2.fastq.gz
out=raw/SRR8365378_HIP2_male_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365379/SRR8365379_2.fastq.gz
out=raw/SRR8365379_HIP2_male_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365380/SRR8365380_2.fastq.gz
out=raw/SRR8365380_HIP2_male_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365381/SRR8365381_2.fastq.gz
out=raw/SRR8365381_HIP3_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365382/SRR8365382_2.fastq.gz
out=raw/SRR8365382_HIP3_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365383/SRR8365383_2.fastq.gz
out=raw/SRR8365383_HIP3_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365384/SRR8365384_2.fastq.gz
out=raw/SRR8365384_HIP3_male_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365385/SRR8365385_2.fastq.gz
out=raw/SRR8365385_HIP3_male_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365386/SRR8365386_2.fastq.gz
out=raw/SRR8365386_HIP3_male_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365387/SRR8365387_2.fastq.gz
out=raw/SRR8365387_HIP3_male_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365388/SRR8365388_2.fastq.gz
out=raw/SRR8365388_HIP3_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365389/SRR8365389_2.fastq.gz
out=raw/SRR8365389_HIP3_male_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365390/SRR8365390_2.fastq.gz
out=raw/SRR8365390_HIP3_male_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365391/SRR8365391_2.fastq.gz
out=raw/SRR8365391_HIP1_female_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365392/SRR8365392_2.fastq.gz
out=raw/SRR8365392_HIP1_female_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365393/SRR8365393_2.fastq.gz
out=raw/SRR8365393_HIP1_female_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365394/SRR8365394_2.fastq.gz
out=raw/SRR8365394_HIP1_female_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365395/SRR8365395_2.fastq.gz
out=raw/SRR8365395_HIP1_female_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365396/SRR8365396_2.fastq.gz
out=raw/SRR8365396_HIP1_female_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365397/SRR8365397_2.fastq.gz
out=raw/SRR8365397_HIP1_female_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365398/SRR8365398_2.fastq.gz
out=raw/SRR8365398_HIP1_female_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365399/SRR8365399_2.fastq.gz
out=raw/SRR8365399_HIP1_female_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365400/SRR8365400_2.fastq.gz
out=raw/SRR8365400_HIP1_female_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365401/SRR8365401_2.fastq.gz
out=raw/SRR8365401_HIP3_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365402/SRR8365402_2.fastq.gz
out=raw/SRR8365402_HIP3_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365413/SRR8365413_2.fastq.gz
out=raw/SRR8365413_HIP3_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365414/SRR8365414_2.fastq.gz
out=raw/SRR8365414_HIP3_male_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365415/SRR8365415_2.fastq.gz
out=raw/SRR8365415_HIP3_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365416/SRR8365416_2.fastq.gz
out=raw/SRR8365416_HIP3_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365417/SRR8365417_2.fastq.gz
out=raw/SRR8365417_HIP3_male_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365425/SRR8365425_2.fastq.gz
out=raw/SRR8365425_HIP3_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365426/SRR8365426_2.fastq.gz
out=raw/SRR8365426_HIP3_male_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365427/SRR8365427_2.fastq.gz
out=raw/SRR8365427_HIP3_male_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365428/SRR8365428_2.fastq.gz
out=raw/SRR8365428_HIP1_female_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365429/SRR8365429_2.fastq.gz
out=raw/SRR8365429_HIP1_female_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365430/SRR8365430_2.fastq.gz
out=raw/SRR8365430_HIP1_female_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365431/SRR8365431_2.fastq.gz
out=raw/SRR8365431_HIP1_female_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365432/SRR8365432_2.fastq.gz
out=raw/SRR8365432_HIP1_female_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365433/SRR8365433_2.fastq.gz
out=raw/SRR8365433_HIP1_female_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365442/SRR8365442_2.fastq.gz
out=raw/SRR8365442_HIP3_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365445/SRR8365445_2.fastq.gz
out=raw/SRR8365445_HIP3_male_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365451/SRR8365451_2.fastq.gz
out=raw/SRR8365451_HIP2_male_IgG1_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365452/SRR8365452_2.fastq.gz
out=raw/SRR8365452_HIP2_male_IgG2_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/003/SRR8365453/SRR8365453_2.fastq.gz
out=raw/SRR8365453_HIP2_male_IgG3_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/004/SRR8365454/SRR8365454_2.fastq.gz
out=raw/SRR8365454_HIP2_male_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/005/SRR8365455/SRR8365455_2.fastq.gz
out=raw/SRR8365455_HIP2_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365466/SRR8365466_2.fastq.gz
out=raw/SRR8365466_HIP3_male_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/002/SRR8365472/SRR8365472_2.fastq.gz
out=raw/SRR8365472_HIP2_male_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365476/SRR8365476_2.fastq.gz
out=raw/SRR8365476_HIP2_male_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365477/SRR8365477_2.fastq.gz
out=raw/SRR8365477_HIP2_male_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/008/SRR8365478/SRR8365478_2.fastq.gz
out=raw/SRR8365478_HIP1_female_IgL_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/009/SRR8365479/SRR8365479_2.fastq.gz
out=raw/SRR8365479_HIP1_female_IgK_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/000/SRR8365480/SRR8365480_2.fastq.gz
out=raw/SRR8365480_HIP1_female_IgA_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/001/SRR8365481/SRR8365481_2.fastq.gz
out=raw/SRR8365481_HIP1_female_IgM_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/006/SRR8365486/SRR8365486_2.fastq.gz
out=raw/SRR8365486_HIP1_female_IgG4_R2.fastq.gz
ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR836/007/SRR8365487/SRR8365487_2.fastq.gz
out=raw/SRR8365487_HIP1_female_IgG3_R2.fastq.gz
The project contains 136 FASTQ file pairs. The above script downloads all the data to raw/ folder. Each file name encodes the data about the donor, its sex and Ig chain. For example for the first file from the above list:
SRR8365277- sample idHIP1- patient idfemale- patient sexIgG1- Ig heavy chain, isotype IGG1.
The structure of the library is shown on the picture bellow.
It is worth noticing, that reads in IgA and IgM cDNA libraries samples cover about 20 and 21 base pairs of C gene, accordingly. In the original paper authors say that these samples were processed at AbHelix, LLC (www.AbHelix.com, South Plainfield, NJ, USA) and briefly emphasise: "For IgG sequencing reads, subclass-specific sequences in the beginning of the constant regions were used for identifying IgG1, IgG2, IgG3, and IgG4 subclass sequences." But, the reads in IgG subtypes samples (IgG1,IgG2,IgG3,IgG4) only cover last 5 nucleotides of the C gene. It is not clear how these subclasses were identified. Nevertheless, we will process all samples as if the primers are located on the J gene/constant region junctions for two reasons:
- For IgA and IgM we don't know what part of the sequence comes from the primers, and IgG cDNA libraries presumably were amplifies using J-C junction primer, since only 5 nucleotides of the C gene are present.
- The samples are already separated by isotypes, thus we don't really need C gene sequence, as we rely on a AbHelix protocol.
Upstream analysis
MiXCR has a dedicated preset for this protocol, thus analysing the data ia as easy as:
mixcr analyze abhelix-human-rna-xcr \
raw/SRR8365277_HIP1_female_IgG1_R1.fastq.gz \
raw/SRR8365277_HIP1_female_IgG1_R2.fastq.gz \
results/SRR8365277_HIP1_female_IgG1
One might also use GNU Parallel to process all samples at once:
#!/usr/bin/env bash
mkdir -p results
ls /raw/*R1* |
parallel -j 2 --line-buffer \
"mixcr analyze abhelix-human-rna-xcr \
{} \
{=s:R1:R2:=} \
{=s:.*/:results/:;s:_R.*::=}"
Under the hood pipeline:
Under the hood the command above actually executes the following pipeline:
align
Alignment of raw sequencing reads against reference database of V-, D-, J- and C- gene segments.
mixcr align \
--species hsa \
-p generic-amplicon \
-OvParameters.geneFeatureToAlign="VTranscriptWithout5UTRWithP" \
-OvParameters.parameters.floatingLeftBound=false \
-OjParameters.parameters.floatingRightBound=true \
--report results/SRR8365277_HIP1_female_IgG1.report \
--json-report results/SRR8365277_HIP1_female_IgG1.json \
raw/SRR8365277_HIP1_female_IgG1_R1.fastq.gz \
raw/SRR8365277_HIP1_female_IgG1_R2.fastq.gz \
results/SRR8365277_HIP1_female_IgG1.vdjca
Option --report is specified here explicitly.
--species hsa- determines the organism species.
-pgeneric-amplicona preset of MiXCR parameters for amplicon data.-OvParameters.geneFeatureToAlign="VTranscriptWithout5UTRWithP"- Sets a V gene feature to align. Check gene features for more info.
-OvParameters.parameters.floatingLeftBound=false- Results in a global alignment algorithm for V gene left bound. We use it because we don't have any primers covering V gene coding sequence.
-OjParameters.parameters.floatingRightBound=true- Results in a local alignment algorithm for J gene right bound. Local alignment is needed because, as have been mentioned above, the primers are most likely cover the right bound of th J gene, at least for IgG samples. The more correct way would be to use separate settings for IgA\IgM libraries, where most likely the primer most likely only covers the C gene. But for the purpose of this tutorial we will use a more universal way, since the exact location of the primers is unknown.
assemble
Assembles alignments into clonotypes and applies several layers of errors correction(ex. quality-dependent correction for sequencing errors, PCR-error correction by clustering). Check mixcr assemble for more information.
mixcr assemble \
-OassemblingFeatures="CDR3" \
-OseparateByJ=true \
-OseparateByV=true \
--report results/SRR8365277_HIP1_female_IgG1.report \
--json-report results/SRR8365277_HIP1_female_IgG1.json \
results/SRR8365277_HIP1_female_IgG1.vdjca \
results/SRR8365277_HIP1_female_IgG1.clns
Options --report and --json-report are specified here explicitly so that the report files will be appended with assembly report.
-OassemblingFeatures={FR1Begin:FR4End}- This is a very important parameter that sets the gene features that will define different clones. By default, only
CDR3is used for naming different clones. But in case of BCR data, due to hypermutations in V region, we should also include V gene sequence, because two different clones may share the sameCDR3. Note, that this is only possible if sequencing reads cover assembling features, which is true in this case.
export
Exports clonotypes from .clns file into human-readable tables.
mixcr exportClones \
-c IGH \
results/SRR8365277_HIP1_female_IgG1.clns \
results/SRR8365277_HIP1_female_IgG1.clonotypes.IGH.txt
-с <chain>- defines a specific chain to be exported.
By the end of upstream analysis you should have the following set of output files:
# human-readable reports
SRR8365277_HIP1_female_IgG1.report
# raw alignments (highly compressed binary file)
SRR8365277_HIP1_female_IgG1.vdjca
# IGH, IGK and IGL clonotypes (highly compressed binary file)
SRR8365277_HIP1_female_IgG1.clns
# IGH, IGK and IGL clonotypes exported in tab-delimited txt
SRR8365277_HIP1_female_IgG1.clonotypes.IGH.txt
While .clns file holds all data and is used for downstream analysis, the output .txt clonotype table will contain exhaustive information about each clonotype as well:
See first 100 records from SRR8365277_HIP1_female_IgG1:
| cloneId | cloneCount | cloneFraction | targetSequences | targetQualities | allVHitsWithScore | allDHitsWithScore | allJHitsWithScore | allCHitsWithScore | allVAlignments | allDAlignments | allJAlignments | allCAlignments | nSeqFR1 | minQualFR1 | nSeqCDR1 | minQualCDR1 | nSeqFR2 | minQualFR2 | nSeqCDR2 | minQualCDR2 | nSeqFR3 | minQualFR3 | nSeqCDR3 | minQualCDR3 | nSeqFR4 | minQualFR4 | aaSeqFR1 | aaSeqCDR1 | aaSeqFR2 | aaSeqCDR2 | aaSeqFR3 | aaSeqCDR3 | aaSeqFR4 | refPoints |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1252 | 0.0210544 | CAGGTGCAGGTGGTACAGTCTGGTGTTGAAGTGAGGAGGCCTGGGTCCTCGGTGAAAGTCTCCTGCAAGGCGTCTGGAGACACATTCAAGAACTGTGTTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGGGGAATCATCCCTCTCTTTGGTACAACTGACTTTGCCCAGAGGTTCCAGGGCAGACTCACAATTACGACGGACGAGTCTACGACCACAGCCTACATGGAACTGAGTAGGCTGAGATCTGAGGACACGGCCACGTACTACTGTGCGGCGGAACTGGGCTTCGGGAAATTATCTGTCGTCTGGGGCCAGGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(1997.9) | IGHD7-2700(35),IGHD1-1400(30),IGHD1-7*00(30) | IGHJ6*00(322) | nan | 57|348|373|0|291|SC66GSG71ASG80TSC82TSG86ASA91GSA94GSG113AST128GSG136ASC140ASG145ASC146GSG148ASA151GSC154TSG188CSA203GSG206ASA216CSG228ASA230TSA231GSA235TSC236TSA239CSA244GSG258CSG263ASC269GSG270ASA278GSC281TSG286CSG302ASC308TSC311GSG333AST334CST338C|1750.0 | 13|20|33|295|302||35.0;25|31|51|292|298||30.0;22|28|51|295|301||30.0 | 45|83|83|320|358|SA57GSC71T|322.0 | nan | CAGGTGCAGGTGGTACAGTCTGGTGTTGAAGTGAGGAGGCCTGGGTCCTCGGTGAAAGTCTCCTGCAAGGCGTCT | 40 | GGAGACACATTCAAGAACTGTGTT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGGGGA | 40 | ATCATCCCTCTCTTTGGTACAACT | 40 | GACTTTGCCCAGAGGTTCCAGGGCAGACTCACAATTACGACGGACGAGTCTACGACCACAGCCTACATGGAACTGAGTAGGCTGAGATCTGAGGACACGGCCACGTACTAC | 40 | TGTGCGGCGGAACTGGGCTTCGGGAAATTATCTGTCGTCTGG | 40 | GGCCAGGGGACCACGGTCATCGTCTCCTCAG | 40 | QVQVVQSGVEVRRPGSSVKVSCKAS | GDTFKNCV | ISWVRQAPGQGLEWMGG | IIPLFGTT | DFAQRFQGRLTITTDESTTTAYMELSRLRSEDTATYY | CAAELGFGKLSVVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285:-5:291:295:-2:-2:302:320:-25:327:358:: |
| 1 | 840 | 0.014126 | CAGGTACAGCTACAGCAGTGGGGCGCAGGACCGTTGAGGCCTTTGGAGACCCTCTCCCTCACCTGCGGTGTATCTGGTGGGTCTTTCAGTGGCTATTACTGGGCCTGGATCCGCCAGTCCCCAGGGAAGGGGCTGGAGTGGATTGGCGAAATCAATGATCGCGGATCCATCAACTACAACCCGTCCCTGAAGAGTCGAGTCAGTATCTCAGTTGACACGTCGAAGAATCACTACTCCCTGAATCTGAGGTCTGTGACCGCCGCGGACACGGCTGTATATTACTGCGCGAGAGAGAGTCACGATATTTTGACTGGGCCCCCTTGGGTCTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTGTCGTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV4-34*00(2413.5) | IGHD3-9*00(80) | IGHJ2*00(442) | nan | 57|349|370|0|292|SG62AST88CSA94GSC100TSG110CSC124GSC128ASA130CSC140TST149CSC152TSA159GSG160CSC174TSG203CSC213GSA216CST218CSA222TSG223CSC226TSC245GSC259GSC260TSA263CSA269TSC278GSC284TSG287CST289ASG299TSC305GSG332AST341C|1934.0 | 36|52|93|298|314||80.0 | 23|73|73|326|376|SC65GSC68G|442.0 | nan | CAGGTACAGCTACAGCAGTGGGGCGCAGGACCGTTGAGGCCTTTGGAGACCCTCTCCCTCACCTGCGGTGTATCT | 40 | GGTGGGTCTTTCAGTGGCTATTAC | 40 | TGGGCCTGGATCCGCCAGTCCCCAGGGAAGGGGCTGGAGTGGATTGGCGAA | 40 | ATCAATGATCGCGGATCCATC | 40 | AACTACAACCCGTCCCTGAAGAGTCGAGTCAGTATCTCAGTTGACACGTCGAAGAATCACTACTCCCTGAATCTGAGGTCTGTGACCGCCGCGGACACGGCTGTATATTAC | 40 | TGCGCGAGAGAGAGTCACGATATTTTGACTGGGCCCCCTTGGGTCTGGTACTTCGATCTCTGG | 40 | GGCCGTGGCACCCTGGTCACTGTGTCGTCAG | 40 | QVQLQQWGAGPLRPLETLSLTCGVS | GGSFSGYY | WAWIRQSPGKGLEWIGE | INDRGSI | NYNPSLKSRVSISVDTSKNHYSLNLRSVTAADTAVYY | CARESHDILTGPPWVWYFDLW | GRGTLVTVSS_ | ::::0:75:99:150:171:282 292:298:-5:-10:314:326:-3:345:376:: |
| 2 | 793 | 0.0133356 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAACAACCATGCTATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATTTTTGGCACATCGAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCGACCAGAACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTATATTACTGTGTGAGAGGAAAAATGAGGGAGATGGCTACAATTTTGAGGGACAAGTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2857.5) | IGHD5-24*00(75) | IGHJ5*00(481) | nan | 57|352|373|0|295|SG145ASG148AST150CSG160ASC218TST224CSG228TSA230GSC281GSG284CSC287ASG335ASC346T|2573.0 | 23|38|60|306|321||75.0 | 20|71|71|328|379|SC24G|481.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAACAACCATGCT | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATTTTTGGCACATCG | 40 | AACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCGACCAGAACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTATATTAC | 40 | TGTGTGAGAGGAAAAATGAGGGAGATGGCTACAATTTTGAGGGACAAGTGGTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFNNHA | INWVRQAPGQGLEWMGG | IIPIFGTS | NYAQKFQGRVTITADESTRTAYMELSSLRSEDTAVYY | CVRGKMREMATILRDKWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:306:-3:-2:321:328:0:348:379:: |
| 3 | 746 | 0.0125452 | CAGGCGCAGGTGGTTCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGCTCTCCTGTAAGGCTTCTGAAGGCACATTCAACAGCTATGCCATCGCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTTACTATAATACACTCAACTACGCACAGAAGTTCCAGGACAGGGTCACAATTACCGCGGACGACTCCACGAACACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTTCTGTGCGAGTGGGGCCAGCCGCTGGTACCCCTACTTCTTTGACTCCTGGGCCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2372.5) | IGHD6-1300(51),IGHD2-200(46) | IGHJ4*00(403) | nan | 57|350|373|0|293|ST61CSC66GSG71TSA91GSG114CSC122TSG133ASC140ASG145AST155CSA159GSG160CSA216TST217AST220ASG222ASG223ASG228CSC229TSA230CSG253ASA257GSG263ASA278CSG286ASC292TSG323CSG335CSA340T|2089.0 | 29|42|63|299|312|SA33C|51.0;5|17|93|300|312|SA8C|46.0 | 19|68|68|315|364|SA23TSA32CSG38C|403.0 | nan | CAGGCGCAGGTGGTTCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGCTCTCCTGTAAGGCTTCT | 40 | GAAGGCACATTCAACAGCTATGCC | 40 | ATCGCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTTACTATAATACACTC | 40 | AACTACGCACAGAAGTTCCAGGACAGGGTCACAATTACCGCGGACGACTCCACGAACACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTTC | 40 | TGTGCGAGTGGGGCCAGCCGCTGGTACCCCTACTTCTTTGACTCCTGG | 40 | GCCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QAQVVQSGAEVRKPGSSVKLSCKAS | EGTFNSYA | IAWVRQAPGQGLEWMGG | IIPYYNTL | NYAQKFQDRVTITADDSTNTVYMELSSLRSDDTAVYF | CASGASRWYPYFFDSW | AQGTLVTVSS_ | ::::0:75:99:150:174:285:-3:293:299:-8:0:312:315:1:333:364:: |
| 4 | 650 | 0.0109308 | GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTCAGACTCTCCTGTGAAGCCTCTGGATTCACCTTCAGAAACTACGACATGCACTGGGTCCGCCAAGGTACAGGAAAAGGTCTGGAGTGGGTCTCAGGAATTAGTGCTGCTGGCGACCCAGACTATGCAGACTCCGTGGAGGGCCGATTCACCATCTCCAGAGAGAATGCCCAGAACTCCTTCTTTCTGCAAATGAACAGCCTTAGAGTCGGCGACACGGCTGTCTATTACTGTGCCAGAACTGACAGAGACTTCTACGGTCTGGACGTCTGGGGCCAAGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-13*00(2279.3) | nan | IGHJ6*00(453) | nan | 57|348|370|0|291|SG110CSC124AST146ASG148ASC175GSC205GST206ASG210ASA213GST221CSA225CST228GSC234GSG238ASA246GSA272GSA279CSG290CSA292TST296GSG311TSC316TSG320CSG332CSA344C|2185.0 | nan | 29|83|83|301|355|SA32TSA40CSC71T|453.0 | nan | GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTCAGACTCTCCTGTGAAGCCTCT | 40 | GGATTCACCTTCAGAAACTACGAC | 40 | ATGCACTGGGTCCGCCAAGGTACAGGAAAAGGTCTGGAGTGGGTCTCAGGA | 40 | ATTAGTGCTGCTGGCGACCCA | 40 | GACTATGCAGACTCCGTGGAGGGCCGATTCACCATCTCCAGAGAGAATGCCCAGAACTCCTTCTTTCTGCAAATGAACAGCCTTAGAGTCGGCGACACGGCTGTCTATTAC | 40 | TGTGCCAGAACTGACAGAGACTTCTACGGTCTGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCATCGTCTCCTCAG | 40 | EVQLVESGGGLVQPGGSLRLSCEAS | GFTFRNYD | MHWVRQGTGKGLEWVSG | ISAAGDP | DYADSVEGRFTISRENAQNSFFLQMNSLRVGDTAVYY | CARTDRDFYGLDVW | GQGTTVIVSS_ | ::::0:75:99:150:171:282:-2:291:::::301:-9:324:355:: |
| 5 | 580 | 0.00975364 | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCTGGTTACACCTTTTTCACCTATGATATTAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATTAGTACCTACAGTGGTGACACAAAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTACTGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2530.7) | IGHD2-200(32),IGHD5-1200(30),IGHD5-18*00(30) | IGHJ5*00(461) | nan | 57|355|373|0|298|SG65CSC82TSA94CSG95TSA123CSA144TSC145TSG148CSG154ASC158TSC209TSC212TSG213AST215CSA220GSA225GSC233GSC246TSG286CSC287TSA297CSG302ASG335ASG351C|2284.0 | 12|24|93|300|312|SA15CST20G|32.0;36|42|69|304|310||30.0;36|42|69|304|310||30.0 | 22|71|71|318|367|SC24T|461.0 | nan | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCT | 40 | GGTTACACCTTTTTCACCTATGAT | 40 | ATTAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATTAGTACCTACAGTGGTGACACA | 40 | AAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTAC | 40 | TGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVHLVQSGVEVKTPGASVKVSCQAS | GYTFFTYD | ISWVRQAPGQGLEWMGW | ISTYSGDT | KYAQKFQGRVTMTTDTSTTTAYLELRSLRSDDTAVYY | CARHHGPTTSENWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:2:298:300:19:-38:312:318:-2:336:367:: |
| 6 | 511 | 0.00859329 | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAACATTTCCTGCAGGGCTTCTGGATTCAGCTTCAGTGACAATCTTATAAATTGGGTGCGCCAAGCCCCCGGACAAAGCCTTGAGTGGATGGGCTGGATTAACCCTGACAATGGAAACACAAGATATTCACAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGCCTACGTGGAGGTGAGCGACCTGACATCTGAAGACACGGCTGTCTATTACTGTGCGAGAGACATACTGTCCGTCGGCCCGCGTGCGAATGATGCTTTTGATGTCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(2151) | IGHD4-1100(30),IGHD4-400(30),IGHD5-5*00(28) | IGHJ3*00(481) | nan | 57|353|373|0|296|SG65ASG71CSA91GSG113CSG114ASA124GSA136TSC139GSC145GSA147GSG148AST150ASG153CSC154TSG158ASC159ASG173ASG188CSA203CSC209TSG213CSG217AST224ASA232GSA244CSA267TSG273CSA276TSC289TSA297GSC303GSA309GSG310ASG316CSG335C|1945.0 | 5|11|48|298|304||30.0;5|11|48|298|304||30.0;5|14|60|296|304|DG9|28.0 | 19|70|70|322|373|SA33G|481.0 | nan | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAACATTTCCTGCAGGGCTTCT | 40 | GGATTCAGCTTCAGTGACAATCTT | 40 | ATAAATTGGGTGCGCCAAGCCCCCGGACAAAGCCTTGAGTGGATGGGCTGG | 40 | ATTAACCCTGACAATGGAAACACA | 40 | AGATATTCACAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGCCTACGTGGAGGTGAGCGACCTGACATCTGAAGACACGGCTGTCTATTAC | 39 | TGTGCGAGAGACATACTGTCCGTCGGCCCGCGTGCGAATGATGCTTTTGATGTCTGG | 40 | GGCCAAGGGACAATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVRKPGASVNISCRAS | GFSFSDNL | INWVRQAPGQSLEWMGW | INPDNGNT | RYSQTFQGRVTISRHSSASIAYVEVSDLTSEDTAVYY | CARDILSVGPRANDAFDVW | GQGTMVTVSS_ | ::::0:75:99:150:174:285:0:296:298:11:-21:304:322:1:342:373:: |
| 7 | 460 | 0.00773564 | GAGGTTCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCTGGATTCTCCTTTAATTCCTATGCCATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTAGTGCTAGAGGCGGGAGTTCATACTTCGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAACCTGAGAGCCGAGGACACGGCCACATATTTCTGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCACTGGGGCCAGGGAACCCTGGTCCTCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-23*00(2218.1) | IGHD5-18*00(51) | IGHJ4*00(333) | nan | 57|352|373|0|295|SG62TST69CSG74AST117GSA138TSG145ASC146TSA147TSG148CSA159GSG160TSC205TSG214CST218AST221CST224GSC227TSA228TSA235TSG257CSC287TSA288GSC289TSA295CSC300GSG310ASG333AST334CSA340T|2109.0 | 25|38|69|303|316|SG35C|51.0 | 26|68|68|319|361|ST31CSA55CSC56T|333.0 | nan | GAGGTTCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCT | 40 | GGATTCTCCTTTAATTCCTATGCC | 40 | ATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTT | 40 | ATTAGTGCTAGAGGCGGGAGTTCA | 40 | TACTTCGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAACCTGAGAGCCGAGGACACGGCCACATATTTC | 40 | TGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCACTGG | 40 | GGCCAGGGAACCCTGGTCCTCGTCTCCTCAG | 40 | EVQLLESGGGLVQPGGSLRLACAAS | GFSFNSYA | MVWVRQAPGKGLEWVSV | ISARGGSS | YFADSVKGRFTISRDNSKNVLSLEMNNLRAEDTATYF | CAKGSIEYSASVDHW | GQGTLVLVSS_ | ::::0:75:99:150:174:285295:303:-2:-8:316:319:-6:330:361:: |
| 8 | 417 | 0.00701253 | CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGACGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATACACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATGTATGGCCCAGCAAAGTACGCACAGAGGTTCCAGGGCAGAGTCACGATCACCGCGGACGAATCCACGACCACTGTCTACATGGAGCTGACCAGCCTGACATCTCAAGACACGGCCGTCTATTACTGTGCGAGAGTTACCTCTATGGTTCGGGGAGTCATCGACAACTGGTTCGACCCCTGGGGCCACGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2641.7) | IGHD3-10*00(67) | IGHJ5*00(481) | nan | 57|352|373|0|295|SA64CSA112CSC158ASA159CSG160ASC218GST220AST224CSA225CSC233GSA244GST266CSG286CSA290TSC292TSG307CSG316CSG321CSG323ASG335C|2370.0 | 37|56|93|301|320|SA46GST53C|67.0 | 20|71|71|322|373|SG45C|481.0 | nan | CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGACGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAGCTATGCT | 40 | ATACACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATGTATGGCCCAGCA | 40 | AAGTACGCACAGAGGTTCCAGGGCAGAGTCACGATCACCGCGGACGAATCCACGACCACTGTCTACATGGAGCTGACCAGCCTGACATCTCAAGACACGGCCGTCTATTAC | 39 | TGTGCGAGAGTTACCTCTATGGTTCGGGGAGTCATCGACAACTGGTTCGACCCCTGG | 40 | GGCCACGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVPLVQSGAEVKKPGSSVTVSCKAS | GGTFSSYA | IHWVRQAPGQGLEWMGG | IIPMYGPA | KYAQRFQGRVTITADESTTTVYMELTSLTSQDTAVYY | CARVTSMVRGVIDNWFDPW | GHGTLVTVSS_ | ::::0:75:99:150:174:285295:301:-6:-6:320:322:0:342:373:: |
| 9 | 380 | 0.00639031 | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCTGGTTACACCTTTTTCACCTATGATATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATTAGTACCTACAGTGGTGACACAAAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTACTGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2561) | IGHD2-200(32),IGHD5-1200(30),IGHD5-18*00(30) | IGHJ5*00(461) | nan | 57|355|373|0|298|SG65CSC82TSA94CSG95TSA123CSA144TSC145TSG148CSG154ASC209TSC212TSG213AST215CSA220GSA225GSC233GSC246TSG286CSC287TSA297CSG302ASG335ASG351C|2313.0 | 12|24|93|300|312|SA15CST20G|32.0;36|42|69|304|310||30.0;36|42|69|304|310||30.0 | 22|71|71|318|367|SC24T|461.0 | nan | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCT | 40 | GGTTACACCTTTTTCACCTATGAT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATTAGTACCTACAGTGGTGACACA | 40 | AAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTAC | 40 | TGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVHLVQSGVEVKTPGASVKVSCQAS | GYTFFTYD | ISWVRQAPGQGLEWMGW | ISTYSGDT | KYAQKFQGRVTMTTDTSTTTAYLELRSLRSDDTAVYY | CARHHGPTTSENWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:2:298:300:19:-38:312:318:-2:336:367:: |
| 10 | 365 | 0.00613806 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAAGTGAGGGAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACAGCTTCACCAGTCTTGACATCAACTGGGTGCGACAGACCGCTGGACAAGGGCTTGAGTGGATGGGATGGATGCAACCTAGTACTGGGAGGACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACCTCCATAAACACAGCCTACATGGAGCTGACTACCCTAACATCTGATGACACGGCCTTTTATTACTGTGCGCGAGGCGTCAGTGCGGGAGTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-8*00(2451.1) | IGHD3-1600(26),IGHD1-2600(25),IGHD3-10*00(25) | IGHJ4*00(420) | nan | 57|357|373|0|300|SG86ASA91GSA93GSC139GST150CSA151TST155CSG174ASA177GSA210CSC212ASA217GSC218TSG220CST224GSA226GSC227GSA273GSG286ASG307CSC308TSG310CSG314ASG316CSG323TSG333TSG335TSA348CSC354G|2159.0 | 53|61|111|302|310|SG55C|26.0;28|33|60|305|310||25.0;47|52|93|305|310||25.0 | 26|68|68|310|352||420.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAAGTGAGGGAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGATACAGCTTCACCAGTCTTGAC | 40 | ATCAACTGGGTGCGACAGACCGCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATGCAACCTAGTACTGGGAGGACA | 40 | GGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACCTCCATAAACACAGCCTACATGGAGCTGACTACCCTAACATCTGATGACACGGCCTTTTATTAC | 39 | TGTGCGCGAGGCGTCAGTGCGGGAGTTGACTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVREPGASVKVSCKAS | GYSFTSLD | INWVRQTAGQGLEWMGW | MQPSTGRT | GYAQKFQGRVTMTRDTSINTAYMELTTLTSDDTAFYY | CARGVSAGVDYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:4:300:302:-16:-13:310:310:-6:321:352:: |
| 11 | 362 | 0.00608761 | CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGATTTCCTGCAAGGCTTCTGGATACACCTTCACTAGATATACTATGAACTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACCCTGACAATGGTAACACAAAATCTTCACAGAAGTTCCAGGACAGAGTCATCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGACCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGGTATTGCAACAGGCCAGCTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(2844.1) | IGHD6-1300(32),IGHD2-800(29) | IGHJ5*00(420) | nan | 57|352|373|0|295|SG114ASC149ASG153ASC159AST161CSG213CSG217ASA235CSG253ASC262TSG302C|2631.0 | 23|35|63|295|307|SA27TSG31A|32.0;1|13|93|295|306|SA5TDT9|29.0 | 29|71|71|313|355||420.0 | nan | CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGATTTCCTGCAAGGCTTCT | 40 | GGATACACCTTCACTAGATATACT | 40 | ATGAACTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGG | 40 | ATCAACCCTGACAATGGTAACACA | 40 | AAATCTTCACAGAAGTTCCAGGACAGAGTCATCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGACCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTAC | 40 | TGTGCGAGAGGTATTGCAACAGGCCAGCTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKISCKAS | GYTFTRYT | MNWVRQAPGQRLEWMGW | INPDNGNT | KSSQKFQDRVIITRDTSASTAYMDLSSLRSEDTAVYY | CARGIATGQLDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:295:-2:-7:307:313:-9:324:355:: |
| 12 | 323 | 0.00543177 | GAGGTTCATCTGTTGGAGTCTGGGGGAGACTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGACTCACCTTTAGCACCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTAGAGTGGGTCTCAGCTATTGGTGGTAGTGGTACTGGTGGTCGCACATATTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGGTGTATCTGCAAATGAACAGTTTGAGAGCCGACGACACGGCCGTATATTACTGTGCGAAGTCGCCTGGGGGTCTAGATGGCTACAATTCCGACTACTACGGAATGGACGTCTGGGGCCAAGGGACCACGGTGACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-23*00(2515.8) | IGHD5-24*00(71) | IGHJ6*00(482) | nan | 57|350|373|0|299|SG62TSG65TSG85ASG123AST135CSG148CSG191ASA210GI222AI222CI222TI222GI222GI222TSA225CSC233TSC291GSC311TSC312TSG323C|2407.0 | 24|41|60|314|331|SA38C|71.0 | 29|83|83|331|385|ST39ASC69G|482.0 | nan | GAGGTTCATCTGTTGGAGTCTGGGGGAGACTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCT | 40 | GGACTCACCTTTAGCACCTATGCC | 40 | ATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTAGAGTGGGTCTCAGCT | 40 | ATTGGTGGTAGTGGTACTGGTGGTCGCACA | 40 | TATTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGGTGTATCTGCAAATGAACAGTTTGAGAGCCGACGACACGGCCGTATATTAC | 40 | TGTGCGAAGTCGCCTGGGGGTCTAGATGGCTACAATTCCGACTACTACGGAATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTGACCGTCTCCTCAG | 40 | EVHLLESGGDLVQPGGSLRLSCTAS | GLTFSTYA | MSWVRQAPGKGLEWVSA | IGGSGTGGRT | YYADSVKGRFTISRDNSKNTVYLQMNSLRADDTAVYY | CAKSPGGLDGYNSDYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:180:291:-3:299:314:-4:1:331:331:-9:354:385:: |
| 13 | 315 | 0.00529723 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGCGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCACTAAATATGCTATCACCTGGGTGCGACAGGCCCCTAGACAAGGGCTTGAGTGGATGGGAGGGATCGTCCCTCTTCCTGGTACAACAAACTACGCACAGAAGTTCCGGGGCAGAGTCACCATTAGCGCGGACGAATCTACGAGCACAGCCTACTTGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGCGGAGTCGGGGGCCTAGGCGGAAGTAGTGGCTGGCCCGATTATGCTTTTGATGTCTGGGGCCAAGGGACTATGGTCATCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2643) | IGHD6-1900(46),IGHD3-2200(40),IGHD5-12*00(40) | IGHJ3*00(394) | nan | 57|350|373|0|293|SA85CSA91GSG145CSC146TSG148ASC149ASG160CSG180ASA210GSA216CSC218TST219CST220CSG228ASA250GSG263CSC268GSC281TSA297T|2379.0 | 27|39|63|315|327|SC29T|46.0;44|52|93|315|323||40.0;30|38|69|317|325||40.0 | 19|70|70|331|382|SG21TSA33GSA50TSC58T|394.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGCGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCACTAAATATGCT | 40 | ATCACCTGGGTGCGACAGGCCCCTAGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCGTCCCTCTTCCTGGTACAACA | 40 | AACTACGCACAGAAGTTCCGGGGCAGAGTCACCATTAGCGCGGACGAATCTACGAGCACAGCCTACTTGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGCGGAGTCGGGGGCCTAGGCGGAAGTAGTGGCTGGCCCGATTATGCTTTTGATGTCTGG | 39 | GGCCAAGGGACTATGGTCATCGTCTCTTCAG | 40 | QVQLVQSGAAVRKPGSSVKVSCKAS | GGTFTKYA | ITWVRQAPRQGLEWMGG | IVPLPGTT | NYAQKFRGRVTISADESTSTAYLELSSLRSEDTAVYY | CASGVGGLGGSSGWPDYAFDVW | GQGTMVIVSS_ | ::::0:75:99:150:174:285:-3:293:315:-6:-3:327:331:1:351:382:: |
| 14 | 296 | 0.00497772 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCAGCTTCAGCAACTTTGTAATCAGTTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGAGGGATCATCCCAAACTTTGGTACAACAAACTACGCACAGAAGTTCCAGGGCAAAGTCACGATTACCGCGGACGAAACTACGAGAACAGCCTACCTGGAGCTGAGTGGCCTGACATCTGAGGACACGTCCGTCTATTACTGTGCGAGAGATGTCGGGGGAGAGGCTACAATTCGCTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2644.2) | IGHD5-24*00(58) | IGHJ4*00(380) | nan | 57|357|373|0|300|SG86ASC139GSG148ASA151TSC154TST155ASC161TSA185GST215AST217ASG228ASG256AST279ASC281TSC287ASA297CSC308TSA309GSG316CSG330TSG335CSC354G|2362.0 | 23|38|60|304|318|DT27|58.0 | 30|68|68|320|358||380.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCAGCTTCAGCAACTTTGTA | 40 | ATCAGTTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCAAACTTTGGTACAACA | 40 | AACTACGCACAGAAGTTCCAGGGCAAAGTCACGATTACCGCGGACGAAACTACGAGAACAGCCTACCTGGAGCTGAGTGGCCTGACATCTGAGGACACGTCCGTCTATTAC | 40 | TGTGCGAGAGATGTCGGGGGAGAGGCTACAATTCGCTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGSFSNFV | ISWVRQAPGQGLEWMGG | IIPNFGTT | NYAQKFQGKVTITADETTRTAYLELSGLTSEDTSVYY | CARDVGGEATIRYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:4:300:304:-3:-2:318:320:-10:327:358:: |
| 15 | 292 | 0.00491045 | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCTGGTTACACCTTTTTCACCTATGATATCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATTAGTACCTACAGTGGTGACACAAAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACTTCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTACTGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2492.7) | IGHD2-200(32),IGHD5-1200(30),IGHD5-18*00(30) | IGHJ5*00(461) | nan | 57|355|373|0|298|SG65CSC82TSA94CSG95TSA123CSA144TSC145TSG148CSG154ASC161TSC209TSC212TSG213AST215CSA220GSA225GSC233GSC246TSA278TSG286CSC287TSA297CSG302ASG335ASG351C|2255.0 | 12|24|93|300|312|SA15CST20G|32.0;36|42|69|304|310||30.0;36|42|69|304|310||30.0 | 22|71|71|318|367|SC24T|461.0 | nan | CAGGTTCACCTGGTGCAGTCTGGAGTTGAGGTGAAGACTCCTGGGGCCTCAGTGAAGGTCTCCTGCCAGGCTTCT | 40 | GGTTACACCTTTTTCACCTATGAT | 40 | ATCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATTAGTACCTACAGTGGTGACACA | 40 | AAGTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACAGACACTTCCACGACTACAGCCTACCTGGAACTGAGGAGCCTGAGATCTGACGACACGGCCGTATATTAC | 40 | TGTGCGAGACATCACGGTCCTACGACATCAGAGAATTGGTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVHLVQSGVEVKTPGASVKVSCQAS | GYTFFTYD | ISWVRQAPGQGLEWMGW | ISTYSGDT | KYAQKFQGRVTMTTDTSTTTAYLELRSLRSDDTAVYY | CARHHGPTTSENWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:2:298:300:19:-38:312:318:-2:336:367:: |
| 16 | 291 | 0.00489363 | CAGGTGCACCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGTTCTGGTTTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATGATCGTCCCCAGTCTTGACACAACAAACTACGCACAGAAGTTCCAGGCCAGAGTCACGATTACCGCGGACGAGGTCACGAGCACAGCCTACATGGAGTTGCGCAGCCTGAGATCTGAGGACACGGCCGTATATTATTGTGCGAGATGGCCACAGCCTCGGTATACTGCTGACCCTTACGCTGTGGACGTCTGGGGCCAAGGGACCAGGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2567.8) | IGHD1-2000(38),IGHD1-700(38),IGHD1-26*00(36) | IGHJ6*00(374) | nan | 57|351|373|0|294|SG65CSG81ASC149TSA151CSC154GSA156TSG204ASG205TSA210GST215CST217GSC218TST219CSG223AST224CSG228ASG253CSA278GST279GSC280TSC303TSA306CSG335ASC341T|2244.0 | 16|27|51|306|316|DA22|38.0;16|27|51|306|316|DA22|38.0;19|29|60|306|316|SG26C|36.0 | 34|83|83|324|373|SG38CSA40GSC65GSC71T|374.0 | nan | CAGGTGCACCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAGTTCTGGT | 40 | TTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATG | 40 | ATCGTCCCCAGTCTTGACACAACA | 40 | AACTACGCACAGAAGTTCCAGGCCAGAGTCACGATTACCGCGGACGAGGTCACGAGCACAGCCTACATGGAGTTGCGCAGCCTGAGATCTGAGGACACGGCCGTATATTAT | 40 | TGTGCGAGATGGCCACAGCCTCGGTATACTGCTGACCCTTACGCTGTGGACGTCTGG | 40 | GGCCAAGGGACCAGGGTCATCGTCTCCTCAG | 40 | QVHLVQSGTEVKKPGSSVKVSCKAS | GGTFSSSG | FSWVRQAPGQGLEWMGM | IVPSLDTT | NYAQKFQARVTITADEVTSTAYMELRSLRSEDTAVYY | CARWPQPRYTADPYAVDVW | GQGTRVIVSS_ | ::::0:75:99:150:174:285:-2:294:306:1:-7:316:324:-14:342:373:: |
| 17 | 274 | 0.00460775 | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGCTGAAGAAGCCTGGGGCCTCAGTGAACATTTCCTGTACGGCTTCTGGATTCACCTTCAGTGACAATCTTATAAATTGGGTGCGCCAAGCCCCCGGACAAGGGCTTGAGTGGATGGGATGGCTCAACCCTGACACTGGAAATACAAGATATTCAGAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGCCTACTTGGAACTCAGCGACCTGGAAAATGAAGACACGGCTCTCTATTTCTGTGCGAGAGACAGGCACAGCGTCGGCCCGCGGGCGAATGATGCTTTTGATGTCTGGGGCCAAGGGACCATGATCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(1924.9) | IGHD2-200(26),IGHD5-500(25),IGHD6-25*00(25) | IGHJ3*00(423) | nan | 57|353|373|0|296|SG65ASG71CSG87CSG113CSG114ASC122TSA124CSA136TSC145GSA147GSG148AST150ASG153CSC154TSG158ASC159ASG173ASA186GSA207CSG213CSG217ASA220CST224ASC227TSA232GSC240GSA244CSA267TSG273CSA276TSC289TSA297TSG302ASG305CSA309GSG310ASA315GSG316AST318ASC319ASG333CSG335CSA340T|1713.0 | 0|8|93|298|306|ST4C|26.0;26|31|60|301|306||25.0;26|31|54|302|307||25.0 | 19|70|70|322|373|SA33GSA50CSG54A|423.0 | nan | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGCTGAAGAAGCCTGGGGCCTCAGTGAACATTTCCTGTACGGCTTCT | 40 | GGATTCACCTTCAGTGACAATCTT | 40 | ATAAATTGGGTGCGCCAAGCCCCCGGACAAGGGCTTGAGTGGATGGGATGG | 40 | CTCAACCCTGACACTGGAAATACA | 40 | AGATATTCAGAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGCCTACTTGGAACTCAGCGACCTGGAAAATGAAGACACGGCTCTCTATTTC | 40 | TGTGCGAGAGACAGGCACAGCGTCGGCCCGCGGGCGAATGATGCTTTTGATGTCTGG | 40 | GGCCAAGGGACCATGATCACCGTCTCTTCAG | 40 | QVQLVQSGAELKKPGASVNISCTAS | GFTFSDNL | INWVRQAPGQGLEWMGW | LNPDTGNT | RYSETFQGRVTISRHSSASIAYLELSDLENEDTALYF | CARDRHSVGPRANDAFDVW | GQGTMITVSS_ | ::::0:75:99:150:174:285:0:296:298:31:-54:306:322:1:342:373:: |
| 18 | 264 | 0.00443959 | CAGGTGCAGGTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAACTATGCTATCAGCTGGGTGCGGCAGGCCCCTGGACATGGACTTGAGTGGGTGGGAGGGATCATCCCTCTGACTGAAACACCAGTCTACGCACAGACGGTCCAGGGCAGACTCACCATTACCGCGGACGAAATCACGAGTGCGGCCTACATGGAGCTGAGCAGCCTGAGATCTGACGACACGGCCGTTTATTATTGTGCGATTGGCACCAGGAACAGCTGGACTTGTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2385.8) | IGHD2-200(38),IGHD1-100(35),IGHD6-13*00(35) | IGHJ4*00(381) | nan | 57|349|373|0|292|SC66GSG74ASG148ASA170GSA185TSG188ASA198GSA216CSC218GST219AST220CSG223AST224ASG228CSA231GSA232TSA244CST246GSG258CSG263CST279ASC280TSC287TSA288GSA290GSG323CSG335TSC341T|2108.0 | 7|18|93|305|315|DT14|38.0;14|29|51|297|313|I17AST19ASA23G|35.0;32|39|63|305|312||35.0 | 27|68|68|317|358|SA32T|381.0 | nan | CAGGTGCAGGTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAACTATGCT | 40 | ATCAGCTGGGTGCGGCAGGCCCCTGGACATGGACTTGAGTGGGTGGGAGGG | 40 | ATCATCCCTCTGACTGAAACACCA | 40 | GTCTACGCACAGACGGTCCAGGGCAGACTCACCATTACCGCGGACGAAATCACGAGTGCGGCCTACATGGAGCTGAGCAGCCTGAGATCTGACGACACGGCCGTTTATTAT | 40 | TGTGCGATTGGCACCAGGAACAGCTGGACTTGTGACTTCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQVVQSGAEVKKPGSSVKVSCKAS | GGTFSNYA | ISWVRQAPGHGLEWVGG | IIPLTETP | VYAQTVQGRLTITADEITSAAYMELSSLRSDDTAVYY | CAIGTRNSWTCDFW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-4:292:305:24:-44:315:317:-7:327:358:: |
| 19 | 247 | 0.0041537 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCGTCTGGATACAGCTTCACCCGTCATGATATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATTAACCCTAGCAGTGGTAACACAGGGTATGCACAGAGGTTTCTGGGCAGACTCACCATGACGACCGACACCTCCACAAGTACAGCCTATATGGAGCTGAGCGGCCTGAAATCTGAGGACACGGCCATATATTACTGTGCGAGAGAGGGCATTCTGTTTTCTGGAGTGATTGTCTTCTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCCCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-8*00(2517.6) | IGHD3-3*00(44) | IGHJ6*00(472) | nan | 57|352|373|0|295|ST128GSC139GSA147CST150CSC161TSA177CSG209TSA217GSC233GSA244GSC248TSA250TSG258CSC269GSG271CSG272CSA273GST283CSC287TSC296TSA309GSG316ASG333ASG335A|2254.0 | 40|54|93|306|321|I44CSG51A|44.0 | 30|83|83|323|376|SA32TST76C|472.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCGTCT | 40 | GGATACAGCTTCACCCGTCATGAT | 40 | ATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATTAACCCTAGCAGTGGTAACACA | 40 | GGGTATGCACAGAGGTTTCTGGGCAGACTCACCATGACGACCGACACCTCCACAAGTACAGCCTATATGGAGCTGAGCGGCCTGAAATCTGAGGACACGGCCATATATTAC | 39 | TGTGCGAGAGAGGGCATTCTGTTTTCTGGAGTGATTGTCTTCTACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCCCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYSFTRHD | INWVRQAPGQGLEWMGW | INPSSGNT | GYAQRFLGRLTMTTDTSTSTAYMELSGLKSEDTAIYY | CAREGILFSGVIVFYGMDVW | GQGTTVTVPS_ | ::::0:75:99:150:174:285295:306:-9:-8:321:323:-10:345:376:: |
| 20 | 246 | 0.00413689 | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAAGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGTAGTTCTGGTTTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATGATCGTCCCCAGCCTTGACACAACAAAGTACGCACAGAAGTTCCAGGCCAGAGTCACGATTACCGCGGACCAGTTCACGAGCACAGCCTACATGGAGTTGAGCAGCCTGAGATCTGAGGACACGGCCGTATATTATTGTGCGAGATGGCCACAGCCTCGGGGTACTGCTGACCCTTACGCTGTGGACGTCTGGGGCCAAGGGACCAGGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2533.6) | IGHD2-1500(33),IGHD2-200(31),IGHD2-8*00(31) | IGHJ6*00(374) | nan | 57|351|373|0|294|SG81ASG113ASC146TSC149TSA151CSC154GSA156TSG204ASG205TSA210GST215CST217GST219CSG223AST224CSG228ASC233GSG253CSG276CSA278GSC280TSC303TSG335ASC341T|2244.0 | 47|57|93|309|318|DG51|33.0;12|21|93|309|318|SA18G|31.0;39|48|93|310|319|SG45C|31.0 | 34|83|83|324|373|SG38CSA40GSC65GSC71T|374.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAAGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGTAGTTCTGGT | 40 | TTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATG | 40 | ATCGTCCCCAGCCTTGACACAACA | 40 | AAGTACGCACAGAAGTTCCAGGCCAGAGTCACGATTACCGCGGACCAGTTCACGAGCACAGCCTACATGGAGTTGAGCAGCCTGAGATCTGAGGACACGGCCGTATATTAT | 39 | TGTGCGAGATGGCCACAGCCTCGGGGTACTGCTGACCCTTACGCTGTGGACGTCTGG | 40 | GGCCAAGGGACCAGGGTCATCGTCTCCTCAG | 40 | QVQLVQSGTEVKKPGSSVKVSCKAS | GGTFSSSG | FSWVRQAPGQGLEWMGM | IVPSLDTT | KYAQKFQARVTITADQFTSTAYMELSSLRSEDTAVYY | CARWPQPRGTADPYAVDVW | GQGTRVIVSS_ | ::::0:75:99:150:174:285:-2:294:309:-16:-5:318:324:-14:342:373:: |
| 21 | 246 | 0.00413689 | CAGGTGCAGGTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCCTCGGTGAAGATCTCCTGTAAGGCCTCTGGACGCATCTTCAGCAGTTTCCCCACTTCCTGGGTGCGACAGGTCCCTGGACAAGGGCTTGAGTGGATGGGAGGGGTCATCAGTGCCTCTGGCTCAGTCACATATGCACCGAAGTTCCAGGGCAGAGTCACGATGACCGCGGTCAATTCCGCGGGCATAGGCTATATGGAGTTGACTAGCCTGACCTCTGAGGACACGGCCATCTATTACTGTGCGAGAGTGGGAAGTAGAGATGCCTACAACTATGTCCTTGATCAGTGGGGCCCGGGGACCATGGTCACCGTCTCGTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(1806) | IGHD5-24*00(68) | IGHJ3*00(147.7) | nan | 57|352|373|0|295|SC66GSG86ASG114ASC122TST128CSG135CSC139TSC149TSA151TST152CSG153CST155CST157CSC158TSA159TSG160CSC175TSA207GSC213ASC214GSA216GST217CST220CST224CSA225TSC229TSA230CSA232CSC233ASC236TSA241CST266GSA274TSG276ASA278TSA282GSA285GSC289TSC292GSC296TSC303TSG307CSC308TSG316CSA317CSG333ASG335C|1587.0 | 20|42|60|301|323|SG29CST36CSC39T|68.0 | 36|70|70|333|367|SA43CSA44GSA50CST65G|224.0 | nan | CAGGTGCAGGTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCCTCGGTGAAGATCTCCTGTAAGGCCTCT | 40 | GGACGCATCTTCAGCAGTTTCCCC | 40 | ACTTCCTGGGTGCGACAGGTCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | GTCATCAGTGCCTCTGGCTCAGTC | 40 | ACATATGCACCGAAGTTCCAGGGCAGAGTCACGATGACCGCGGTCAATTCCGCGGGCATAGGCTATATGGAGTTGACTAGCCTGACCTCTGAGGACACGGCCATCTATTAC | 40 | TGTGCGAGAGTGGGAAGTAGAGATGCCTACAACTATGTCCTTGATCAGTGG | 40 | GGCCCGGGGACCATGGTCACCGTCTCGTCAG | 40 | QVQVVQSGAEVKKPGSSVKISCKAS | GRIFSSFP | TSWVRQVPGQGLEWMGG | VISASGSV | TYAPKFQGRVTMTAVNSAGIGYMELTSLTSEDTAIYY | CARVGSRDAYNYVLDQW | GPGTMVTVSS_ | ::::0:75:99:150:174:285295:301:0:2:323:333:-16:336:367:: |
| 22 | 245 | 0.00412007 | CAGGTCCAACTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCACGGCATCTGGATACACCTTCACTCACTATGCTATTCATTGGGTGCGCCACGCCCCCGGACAAAGGCTTGAGTGGATGGGATTCATCAACGCTGGCAGTGGTAACACAAAATATTCACAGACTTTTCAGGGAAGACTCACATTTACCAAAGACACATCCGCGAGCACAGCCTACATGGACCTGAGCAGCCTGAGATCTGAAGACACGGCTATATATTACTGTGCAAGAGGCTTAGCAGCAGATGGTGCCTGGGGCCAGGGAACGCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(2495.8) | IGHD6-13*00(56) | IGHJ5*00(331) | nan | 57|352|373|0|295|SG65ASA124CST128ASA147CSG148ASG158TSG173CSG205TSG206CSA220GSA244CSG245TSC248TSC254ASG258CSC263ASA264TSG271ASG272ASG302CSG333ASG335ASG347A|2283.0 | 26|40|63|298|312|SC35A|56.0 | 35|71|71|313|349|SC51G|331.0 | nan | CAGGTCCAACTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCACGGCATCT | 40 | GGATACACCTTCACTCACTATGCT | 40 | ATTCATTGGGTGCGCCACGCCCCCGGACAAAGGCTTGAGTGGATGGGATTC | 40 | ATCAACGCTGGCAGTGGTAACACA | 40 | AAATATTCACAGACTTTTCAGGGAAGACTCACATTTACCAAAGACACATCCGCGAGCACAGCCTACATGGACCTGAGCAGCCTGAGATCTGAAGACACGGCTATATATTAC | 39 | TGTGCAAGAGGCTTAGCAGCAGATGGTGCCTGG | 40 | GGCCAGGGAACGCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCTAS | GYTFTHYA | IHWVRHAPGQRLEWMGF | INAGSGNT | KYSQTFQGRLTFTKDTSASTAYMDLSSLRSEDTAIYY | CARGLAADGAW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:298:-5:-2:312:313:-15:318:349:: |
| 23 | 245 | 0.00412007 | CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTCACTATGGCATCCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGTTGGCAGTTATTTCATATGATGGAAGTAATAAACACTATGCAGACTCCGTGAAGGGCCGATTCACCGTCTCCAGAGACAATTCCAAGAACACGCTGTACCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTCTATTTCTGTGCGAGATATAGTGGGAAGTACCAGGGTCCCATTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-30*00(2688.3) | IGHD1-2600(50),IGHD5-1200(50),IGHD5-18*00(45) | IGHJ4*00(420) | nan | 57|349|373|0|292|SC66TSA147CSG148ASG158CSG198TSA209TST231CSA264GST296CSG335CSA340T|2601.0 | 22|32|60|294|304||50.0;26|36|69|292|302||50.0;27|36|69|293|302||45.0 | 26|68|68|319|361||420.0 | nan | CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCT | 40 | GGATTCACCTTCAGTCACTATGGC | 40 | ATCCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGTTGGCAGTT | 40 | ATTTCATATGATGGAAGTAATAAA | 40 | CACTATGCAGACTCCGTGAAGGGCCGATTCACCGTCTCCAGAGACAATTCCAAGAACACGCTGTACCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTCTATTTC | 40 | TGTGCGAGATATAGTGGGAAGTACCAGGGTCCCATTGACTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVESGGGVVQPGRSLRLSCAAS | GFTFSHYG | IHWVRQAPGKGLEWLAV | ISYDGSNK | HYADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTAVYF | CARYSGKYQGPIDYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-4:292:294:-2:-8:304:319:-6:330:361:: |
| 24 | 230 | 0.00386782 | GAGGTTCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCTGGATTCTCCTTTAATTCCTATGCCATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTAGTGCCAGAGGCGGGAGTTCATACTTCGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAACCTGAGAGCCGAGGACACGGCCACATATTTCTGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCGCTGGGGCCAGGGAACCCTGGTCCTCGTCTCGTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-23*00(2187.3) | IGHD5-18*00(51) | IGHJ5*00(284) | nan | 57|352|373|0|295|SG62TST69CSG74AST117GSA138TSG145ASC146TSA147TSG148CSA159GSG160TSC205TSG214CST215CST218AST221CST224GSC227TSA228TSA235TSG257CSC287TSA288GSC289TSA295CSC300GSG310ASG333AST334CSA340T|2080.0 | 25|38|69|303|316|SG35C|51.0 | 31|71|71|321|361|SC35GSA58CSC59TSC66G|284.0 | nan | GAGGTTCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCT | 40 | GGATTCTCCTTTAATTCCTATGCC | 40 | ATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTT | 40 | ATTAGTGCCAGAGGCGGGAGTTCA | 40 | TACTTCGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAACCTGAGAGCCGAGGACACGGCCACATATTTC | 40 | TGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCGCTGG | 40 | GGCCAGGGAACCCTGGTCCTCGTCTCGTCAG | 40 | EVQLLESGGGLVQPGGSLRLACAAS | GFSFNSYA | MVWVRQAPGKGLEWVSV | ISARGGSS | YFADSVKGRFTISRDNSKNVLSLEMNNLRAEDTATYF | CAKGSIEYSASVDRW | GQGTLVLVSS_ | ::::0:75:99:150:174:285295:303:-2:-8:316:321:-11:330:361:: |
| 25 | 229 | 0.003851 | CAGGTGCAACTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAACAGATATGCTATCAGCTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGAGGAATCATCCCTATATTTGGGATAGGAAACGACGCACAGAGGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGGGCACAGCGTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGGCGTGTATTACTGTGCGAGATCGGCTATTACGCTTTTTGGAGTGGTTTCTATTCCTCCACACTACTACTCTGAAATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2822.5) | IGHD3-3*00(96) | IGHJ6*00(454) | nan | 57|351|373|0|294|SG65ASG145ASC149AST179ASG206ASC218AST224GSC226TSC229GST234GSA244GSA285GSC293GSG323ASC331G|2505.0 | 32|54|93|299|321|SA39C|96.0 | 26|83|83|334|391|SA35CSC36TSG38AST39A|454.0 | nan | CAGGTGCAACTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAACAGATATGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGAGGA | 40 | ATCATCCCTATATTTGGGATAGGA | 40 | AACGACGCACAGAGGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGGGCACAGCGTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGGCGTGTATTAC | 40 | TGTGCGAGATCGGCTATTACGCTTTTTGGAGTGGTTTCTATTCCTCCACACTACTACTCTGAAATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFNRYA | ISWVRQAPGQGLEWMGG | IIPIFGIG | NDAQRFQGRVTITADESTGTAYMELSSLRSEDTGVYY | CARSAITLFGVVSIPPHYYSEMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-2:294:299:-1:-8:321:334:-6:360:391:: |
| 26 | 228 | 0.00383419 | CAGGTGTACCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGATCTCCTGCAAGGCCTCTGGAGGCATCTTCAGCAGCAATACTATCAACTGGGTGCGACAGGCCGCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCCCTCTTTGGAACAGCAAACTATGCAGAGAAGTTCCAGGGCAGAGTCACCATTACCGCGGACAAATCCACGAAGACAGAGTATATGGAGTTGACGAGCCTGAGATCTGAGGACACGGCCGTCTATTACTGTGCGAGCAAAGCAGCTTGTGGTGGTGACTGCTATGCCTTTGACTCCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2484) | IGHD2-21*00(83) | IGHJ4*00(382) | nan | 57|350|373|0|293|SC63TSG65CSG114AST128CSC139TST150ASG153ASG160ASC177GST215CSA216CST224ASC236TSC240GSG263CSG276ASG286ASC287GSC292ASC293GSC296TSC303TSG307CSC308GSG335C|2205.0 | 28|53|84|296|321|ST32GSA33CST46C|83.0 | 24|68|68|323|367|SA32CSC63G|382.0 | nan | CAGGTGTACCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGATCTCCTGCAAGGCCTCT | 40 | GGAGGCATCTTCAGCAGCAATACT | 40 | ATCAACTGGGTGCGACAGGCCGCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCCCTCTTTGGAACAGCA | 40 | AACTATGCAGAGAAGTTCCAGGGCAGAGTCACCATTACCGCGGACAAATCCACGAAGACAGAGTATATGGAGTTGACGAGCCTGAGATCTGAGGACACGGCCGTCTATTAC | 40 | TGTGCGAGCAAAGCAGCTTGTGGTGGTGACTGCTATGCCTTTGACTCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCGTCAG | 40 | QVYLVQSGAEVKKPGSSVKISCKAS | GGIFSSNT | INWVRQAAGQGLEWMGG | IIPLFGTA | NYAEKFQGRVTITADKSTKTEYMELTSLRSEDTAVYY | CASKAACGGDCYAFDSW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-3:293:296:0:-3:321:323:-4:336:367:: |
| 27 | 225 | 0.00378374 | CAGGTGCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTCTGGTATGAGCTGGGTGCGGCAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGGATCAGTGCACACACTGGTAGCTCAGAGTATGCACAGAGGTTCCAGGGCAGAGTCACCATGACCACAGACAGATCCACGAGCACTGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTTTATTACTGTGCGAGAGCGTTCTTCTATCAGGGTAGTGATAGTCGTGGTTATTCCTTTGATGCTTTTGATTTCTGGGGCCCAGGGACACTGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2861.7) | IGHD3-22*00(72) | IGHJ3*00(413) | nan | 57|352|373|0|295|ST62GSA151CSC158GSA170GSG188ASC212TST215AST216CSA220CSA226GSA228TSA231GSC233GSA244GSC246TSC277GSA290TSG335T|2428.0 | 40|60|93|314|334|SA47CSA57C|72.0 | 20|70|70|335|385|SA33TSA43CSA51C|413.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACCTTTACCAGCTCTGGT | 40 | ATGAGCTGGGTGCGGCAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGG | 40 | ATCAGTGCACACACTGGTAGCTCA | 40 | GAGTATGCACAGAGGTTCCAGGGCAGAGTCACCATGACCACAGACAGATCCACGAGCACTGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTTTATTAC | 40 | TGTGCGAGAGCGTTCTTCTATCAGGGTAGTGATAGTCGTGGTTATTCCTTTGATGCTTTTGATTTCTGG | 40 | GGCCCAGGGACACTGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTFTSSG | MSWVRQAPGQGLEWMGW | ISAHTGSS | EYAQRFQGRVTMTTDRSTSTAYMELRSLRSDDTAVYY | CARAFFYQGSDSRGYSFDAFDFW | GPGTLVTVSS_ | ::::0:75:99:150:174:285295:314:-9:-2:334:335:0:354:385:: |
| 28 | 218 | 0.00366602 | CAGGTTCAGTTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGACGGTCTCCTGCAAGACTTCTGGCTACACCTTTAGCAACTATGGAATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGTTGGATCAGCGGTTACAATGGCAACACAAATTATGCACAGACCGTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGGGCACAGTATACATGGAGCTGAGGAGCCTGAAATCTGACGACACGGCCATATACTATTGTTCGAGGTTTATTATGGTCGGTGGCTGGTTCGACCCGAACTACTATCACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2583.3) | IGHD6-19*00(49) | IGHJ6*00(512) | nan | 57|350|373|0|293|SC66TSA112CSG126AST134CSC145GSG148AST155ASG160ASC161TSA203TSC214GST224CSC233TSA244CSG245CSC246GSA285GSC292TSC293ASG316ASG333ASG335AST338CSC341TSG345T|2205.0 | 31|47|63|307|322|SA40TDT43|49.0 | 26|83|83|325|382|SC33TST34C|512.0 | nan | CAGGTTCAGTTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGACGGTCTCCTGCAAGACTTCT | 40 | GGCTACACCTTTAGCAACTATGGA | 40 | ATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGTTGG | 40 | ATCAGCGGTTACAATGGCAACACA | 40 | AATTATGCACAGACCGTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGGGCACAGTATACATGGAGCTGAGGAGCCTGAAATCTGACGACACGGCCATATACTAT | 40 | TGTTCGAGGTTTATTATGGTCGGTGGCTGGTTCGACCCGAACTACTATCACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVTVSCKTS | GYTFSNYG | INWVRQAPGQGLEWMGW | ISGYNGNT | NYAQTVQGRVTMTTDTSTGTVYMELRSLKSDDTAIYY | CSRFIMVGGWFDPNYYHGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-3:293:307:-10:5:322:325:-6:351:382:: |
| 29 | 210 | 0.00353149 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGATGCAGCAGCCTGGGGCCTCGGTGAGGGTCTCCTGCAAGGCGTCTGGAGGCACCTTCAGCAAATATGCTTTCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGCTCGGAGGGACCATCCCTATGTTTGGAACACCAAACTACGCACAGAAGTTCCAGGGCAGAGTCGCCATCTCCGCGGACGAATCGACGGCTACAGTCTACATGGAGTTGAGCAGCCTGAGATCTGAGGACACGGCCGTCTATTTCTGTGCGAGACCACTACGTGATAGAAACTACTACTACGGTATGGCCGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2357.2) | IGHD1-700(35),IGHD2-1500(35),IGHD3-22*00(35) | IGHJ6*00(541) | nan | 57|351|373|0|294|SG87ASA90CSA93CST102GSA112GST128GSG148ASC149ASA156TSC161TSA198CSG200CST208CSC218GST224ASG228CSA261GSG263CST266CSA267TSC281GSA285GSG286CSC287TSC292TSC303TSG335CSA340T|2128.0 | 29|36|51|296|303||35.0;16|23|93|294|301||35.0;10|17|93|294|301||35.0 | 26|83|83|310|367|SA44C|541.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGATGCAGCAGCCTGGGGCCTCGGTGAGGGTCTCCTGCAAGGCGTCT | 40 | GGAGGCACCTTCAGCAAATATGCT | 40 | TTCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGCTCGGAGGG | 40 | ACCATCCCTATGTTTGGAACACCA | 40 | AACTACGCACAGAAGTTCCAGGGCAGAGTCGCCATCTCCGCGGACGAATCGACGGCTACAGTCTACATGGAGTTGAGCAGCCTGAGATCTGAGGACACGGCCGTCTATTTC | 40 | TGTGCGAGACCACTACGTGATAGAAACTACTACTACGGTATGGCCGTCTGG | 39 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEMQQPGASVRVSCKAS | GGTFSKYA | FSWVRQAPGQGLEWLGG | TIPMFGTP | NYAQKFQGRVAISADESTATVYMELSSLRSEDTAVYF | CARPLRDRNYYYGMAVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-2:294:296:-12:2:303:310:-6:336:367:: |
| 30 | 208 | 0.00349786 | CAGGGGCAGCTGGTGCAGTCCGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCACCTACTACATACACTGGATGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATGTTCAACCCCTACACTGGTGGCACAAGATACGCACATAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGGCTACATGGAGCTGAGTAGGTTGAGATCTGACGACACGGCCGTGTATTATTGTGCGAGACTGTGGGGTGAAATAGGAACCGCGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-46*00(2811.2) | IGHD2-2100(38),IGHD5-1800(33) | IGHJ5*00(440) | nan | 57|351|373|0|294|ST61GST77CSG148CST155CSG158ASG165ASA206GSA207TST215CSA216TSG217AST218CSG219ASG220CSA225GSC233ASG242TSA270GST292GSC308TSC311GSC312TSG323CSC341T|2244.0 | 35|46|84|295|305|DT40|38.0;23|33|69|301|310|DT28|33.0 | 27|71|71|317|361||440.0 | nan | CAGGGGCAGCTGGTGCAGTCCGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCT | 40 | GGATACACCTTCACCACCTACTAC | 40 | ATACACTGGATGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATG | 40 | TTCAACCCCTACACTGGTGGCACA | 40 | AGATACGCACATAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGGCTACATGGAGCTGAGTAGGTTGAGATCTGACGACACGGCCGTGTATTAT | 40 | TGTGCGAGACTGTGGGGTGAAATAGGAACCGCGTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QGQLVQSGAEVKKPGASVKVSCKAS | GYTFTTYY | IHWMRQAPGQGLEWMGM | FNPYTGGT | RYAHKFQGRVTMTGDTSTSTGYMELSRLRSDDTAVYY | CARLWGEIGTAFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-2:294:295:-7:-10:305:317:-7:330:361:: |
| 31 | 207 | 0.00348104 | CAGTTTCAACTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGTAAGGCCTCTGGTTACAACTTTACCAGATTTGGTATCAGCTGGGTGCGACAGGCCCCAGGACACGGGCTTGAGTGGATGGGATGGATGGGCGCTCACAGTGGTCACACAAGGCAAGCACAGAAGTTCCAGGGCAGACTCACCATGACCACAGACGCTTCCATGAACACAGCCTATATTGACCTGAGGAGCCTGACATCTGACGACACGGCCCTCTATTACTGTGGGAGAGAGGGGCAGCAACTGGCCCAGGAAGATTACTACCAATTCAACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2291.9) | IGHD6-1300(41),IGHD1-100(35) | IGHJ6*00(487) | nan | 57|353|373|0|296|SG60TSG65ASC122TST128CSC139ASC149ASA151TST179ASA185CSC209GSA210GST216CSA220GSA225CSA232GSC233GST234CST236ASC246TSG258CSA276GSA278TSC283TSG286ASC296TSG299TSG302CSG316CSG333CSG335CSC346G|2061.0 | 28|39|63|299|310|SG34A|41.0;21|28|51|303|310||35.0 | 14|83|83|313|382|ST16GST19GST28CSC30ASA32TST34ASC71T|487.0 | nan | CAGTTTCAACTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGTAAGGCCTCT | 40 | GGTTACAACTTTACCAGATTTGGT | 40 | ATCAGCTGGGTGCGACAGGCCCCAGGACACGGGCTTGAGTGGATGGGATGG | 40 | ATGGGCGCTCACAGTGGTCACACA | 40 | AGGCAAGCACAGAAGTTCCAGGGCAGACTCACCATGACCACAGACGCTTCCATGAACACAGCCTATATTGACCTGAGGAGCCTGACATCTGACGACACGGCCCTCTATTAC | 40 | TGTGGGAGAGAGGGGCAGCAACTGGCCCAGGAAGATTACTACCAATTCAACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCATCGTCTCCTCAG | 40 | QFQLVQSGAEVKKPGASVKVSCKAS | GYNFTRFG | ISWVRQAPGHGLEWMGW | MGAHSGHT | RQAQKFQGRLTMTTDASMNTAYIDLRSLTSDDTALYY | CGREGQQLAQEDYYQFNGMDVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285:0:296:299:-7:-3:310:313:6:351:382:: |
| 32 | 206 | 0.00346422 | CACGAGCACCTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGGCCTCCCTGAAGGTCTCCTGCAAGGCTTCTGGATACAGTTTCACCGGCTACTATATTCATTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGGATCAACCCTGACAGTGGTGCCACAAACTACGCACAGAACTTTCAGGGCAGGGTCACCCTGACCAGCGACACGTCCATCAGCACAGCCTCCATGGACCTGACCAGTCTGACATCTGACGACACGGCCGTCTATTACTGTGCGAGAGGCGACTATGGGACTGGTGGTTATCCTTTTCCTTACTTTGACTATTGGGGCCAGGGAACCCTGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-2*00(2612.3) | IGHD2-800(51),IGHD3-2200(44) | IGHJ4*00(402) | nan | 57|352|373|0|295|SG59CST61ASG65CSA94GSA107CSG108CSC139GSC140TSG158TSC161TSG188ASA216GSG226CST236CSG245CST255ASA264CSG272CSA295CSG302CSG307CSG311TSG316CSG335C|2254.0 | 35|57|93|300|321|ST38GST40GDG50SG54C|51.0;36|56|93|298|318|SA42GST43GSG45CSA47G|44.0 | 22|68|68|327|373|SC33TSC56T|402.0 | nan | CACGAGCACCTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGGCCTCCCTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGATACAGTTTCACCGGCTACTAT | 40 | ATTCATTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGG | 40 | ATCAACCCTGACAGTGGTGCCACA | 40 | AACTACGCACAGAACTTTCAGGGCAGGGTCACCCTGACCAGCGACACGTCCATCAGCACAGCCTCCATGGACCTGACCAGTCTGACATCTGACGACACGGCCGTCTATTAC | 39 | TGTGCGAGAGGCGACTATGGGACTGGTGGTTATCCTTTTCCTTACTTTGACTATTGG | 40 | GGCCAGGGAACCCTGGTCATCGTCTCCTCAG | 40 | HEHLVQSGAEVKRPGASLKVSCKAS | GYSFTGYY | IHWVRQAPGQGLEWMGW | INPDSGAT | NYAQNFQGRVTLTSDTSISTASMDLTSLTSDDTAVYY | CARGDYGTGGYPFPYFDYW | GQGTLVIVSS_ | ::::0:75:99:150:174:285295:300:-4:-5:321:327:-2:342:373:: |
| 33 | 199 | 0.00334651 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCACGGCTTCTGGAGGCTCCCTCAGGAACTCTGTTATCAGCTGGGTGCGACAGGCCCCTGCACAAAGACTTGAGTGGATGGGGGGGGTCATCCCTATCCTTGGTACAGCCAACTACGCGCAGAAGTTTCAGGGCAGAGTCACGATGACCGCGGACGAGGCCACCAGTACAGCCTACATGGACTTGAGCAGCCTGAGCCCTGACGACACGGCCGTATATTACTGTGCGAGACTCGGTCACCCTGGCCACTGGGGCCCGGGAACCCTGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2417) | IGHD4-17*00(30) | IGHJ400(302),IGHJ500(293) | nan | 57|351|373|0|294|SG110TSA124CSA138TST141CSC146GSG148ASA151CSC154TSG181CSG186ASG188ASA203GSA207GST219CSA230CSA239GSC248TST266GSA278GST279GSG284CSC287TSG302CSC303TSA317CST318CSG323CSG335A|2128.0 | 3|9|48|298|304||30.0 | 32|68|68|310|346|SA41CSC56T|302.0;33|71|71|308|346|SC35ASA44CSC59T|293.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCACGGCTTCT | 40 | GGAGGCTCCCTCAGGAACTCTGTT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGCACAAAGACTTGAGTGGATGGGGGGG | 40 | GTCATCCCTATCCTTGGTACAGCC | 40 | AACTACGCGCAGAAGTTTCAGGGCAGAGTCACGATGACCGCGGACGAGGCCACCAGTACAGCCTACATGGACTTGAGCAGCCTGAGCCCTGACGACACGGCCGTATATTAC | 40 | TGTGCGAGACTCGGTCACCCTGGCCACTGG | 40 | GGCCCGGGAACCCTGGTCATCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCTAS | GGSLRNSV | ISWVRQAPAQRLEWMGG | VIPILGTA | NYAQKFQGRVTMTADEATSTAYMDLSSLSPDDTAVYY | CARLGHPGHW | GPGTLVIVSS_ | ::::0:75:99:150:174:285:-2:294:298:13:-23:304:310:-12:315:346:: |
| 34 | 198 | 0.00332969 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGAGGGGGTCTACGCGGTGACCCCCAAAAACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(3237.3) | IGHD3-1600(40),IGHD4-1700(35) | IGHJ6*00(480) | nan | 57|352|373|0|295||2950.0 | 15|23|111|316|324||40.0;22|29|48|310|317||35.0 | 35|83|83|325|373||480.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAGCTATGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATCTTTGGTACAGCA | 40 | AACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGAGGGGAGGGGGTCTACGCGGTGACCCCCAAAAACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSSYA | ISWVRQAPGQGLEWMGG | IIPIFGTA | NYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYY | CARGEGVYAVTPKNGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285295:316:22:-51:324:325:-15:342:373:: |
| 35 | 196 | 0.00329606 | CAGGTGCAGGTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGCAGCTTTGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGTCTCTTATATGGTATGATGGAAGTAAAAAATCGTATGGAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAGGAATACGGTGTATTTGCAAATGAACAGCCTGAGAGCCGACGACACGGCTGTCTATTACTGTGCGCGAGATGCTTCGTATTACAGTCTTTGGAGTGGTTATTACCCCTCACGCAACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-33*00(2567.3) | IGHD3-3*00(98) | IGHJ6*00(480) | nan | 57|354|373|0|297|SC66GST146CSA151TSG201TSA203TSG204CST227ASA232CSC233GSC238GSA283GSC287TSC291GSC297TSG323CSG335CSA348C|2477.0 | 30|58|93|301|329|SG38ASA39GST41C|98.0 | 35|83|83|340|388||480.0 | nan | CAGGTGCAGGTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCT | 40 | GGATTCACCTTCAGCAGCTTTGGC | 40 | ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGTCTCTT | 40 | ATATGGTATGATGGAAGTAAAAAA | 40 | TCGTATGGAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAGGAATACGGTGTATTTGCAAATGAACAGCCTGAGAGCCGACGACACGGCTGTCTATTAC | 40 | TGTGCGCGAGATGCTTCGTATTACAGTCTTTGGAGTGGTTATTACCCCTCACGCAACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQVVESGGGVVQPGRSLRLSCAAS | GFTFSSFG | MHWVRQAPGKGLEWVSL | IWYDGSKK | SYGDSVKGRFTISRDNSRNTVYLQMNSLRADDTAVYY | CARDASYYSLWSGYYPSRNGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:1:297:301:1:-4:329:340:-15:357:388:: |
| 36 | 189 | 0.00317834 | CAGCTACAGCTGGTGCAGTCTGGGGCTGAGGTGAGGGAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGTTATACTGTCATCTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGAGGGATCACCCCTACATTAAATATAGCTAAGTACGCAGAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAGTCCACGAGCACAGTCAACATGCACCTGAGCAGCCTGAGATCTGAGGACACGGCCGTCTATTTCTGTGCGAGAGGCTACTACAGTGGGAGCAACCCGTCCTCCTTTGACTACTGGGGCCAGGGAACCCTGGTCGCCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2485) | IGHD1-2600(47),IGHD2-200(40),IGHD4-11*00(40) | IGHJ4*00(413) | nan | 57|352|373|0|295|SG60CSG62ASA91GSA93GSC149TSG153ASA156GSG160TSA185GST211CST217CSC218AST221ASG222ASG223ASC226TSA230TSC233GSC240GSA278GSC292TST294ASG300CSG302CSG335CSA340T|2196.0 | 22|37|60|300|315|ST24CST34A|47.0;16|24|93|296|304||40.0;18|26|48|298|306||40.0 | 18|68|68|317|367|SA20CSA23CSA55G|413.0 | nan | CAGCTACAGCTGGTGCAGTCTGGGGCTGAGGTGAGGGAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAGTTATACT | 40 | GTCATCTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGAGGG | 40 | ATCACCCCTACATTAAATATAGCT | 40 | AAGTACGCAGAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAGTCCACGAGCACAGTCAACATGCACCTGAGCAGCCTGAGATCTGAGGACACGGCCGTCTATTTC | 40 | TGTGCGAGAGGCTACTACAGTGGGAGCAACCCGTCCTCCTTTGACTACTGG | 40 | GGCCAGGGAACCCTGGTCGCCGTCTCCTCAG | 40 | QLQLVQSGAEVREPGSSVKVSCKAS | GGTFSSYT | VIWVRQAPGQGLEWMGG | ITPTLNIA | KYAEKFQGRVTITADESTSTVNMHLSSLRSEDTAVYF | CARGYYSGSNPSSFDYW | GQGTLVAVSS_ | ::::0:75:99:150:174:285295:300:-2:-3:315:317:2:336:367:: |
| 37 | 187 | 0.00314471 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCGGGAGGCACCTTCAGCAGCTCTGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAATGGATGGGAGCGATCATCCCTGTCTTTGGAACAGCGCACTACGCACAGAAGTTCCAGGGCAGAGTCACCATTACCGCCGACAAACCCACGAGCACAGCCTACATGGAACTGAGCAGGCTCAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGAGCGGCCAGAGAGGGGTAAGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2807.8) | IGHD5-2400(25),IGHD6-2500(25) | IGHJ6*00(431) | nan | 57|353|373|0|296|ST131GSA151CSG194ASG205CSA216GST224ASA230GSA231CSG263CSG272CSG276AST279CSG302ASC311GSG314C|2525.0 | 22|27|60|302|307||25.0;28|33|54|296|301||25.0 | 37|83|83|309|355|ST41A|431.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCG | 40 | GGAGGCACCTTCAGCAGCTCTGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAATGGATGGGAGCG | 40 | ATCATCCCTGTCTTTGGAACAGCG | 40 | CACTACGCACAGAAGTTCCAGGGCAGAGTCACCATTACCGCCGACAAACCCACGAGCACAGCCTACATGGAACTGAGCAGGCTCAGATCTGAGGACACGGCCGTGTATTAC | 39 | TGTGCGAGAGAGCGGCCAGAGAGGGGTAAGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSSSA | ISWVRQAPGQGLEWMGA | IIPVFGTA | HYAQKFQGRVTITADKPTSTAYMELSRLRSEDTAVYY | CARERPERGKDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:0:296:302:-2:-13:307:309:-17:324:355:: |
| 38 | 186 | 0.00312789 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGACGTGAAGAAGCCTGGGTCGTCGGTGAAGGTCTCCTGCAAGACTTCTGGAGGCTCCTTCGGCAGTTCTGCTATCAGCTGGGTGCGACAGGCCCCCGCACAAGGGCTTGAGTGGATGGGAGAGATCATCCCTGTTTTTGATAAAGCGAACTACGCTCAGAACTTCCAGGGCAGACTGACCATTACCGCGGACGAACTCACGGGAACAGTGTTCATGGAATTGAGTAGCCTGAGATCTGAGGACACGGCCGTGTATTTCTGTGCGAGACTAAGGAGGGATTGGGGTGATGCATTTGATCTCTGGGGCCTAGGGACATTCGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2322.8) | IGHD3-16*00(30) | IGHJ3*00(355) | nan | 57|351|373|0|294|SG86CSC104GSG126ASA138TSA144GSC149TSA151CST179CSG181CSG205ASA216GSC218TSG223ASC226ASA230GSA239TSG245CSG258CSC260GSG263CST279CSC280TSA285GSC287ASC292TSC293GSA295TSG302ASC303TSC308TSA340T|2041.0 | 52|58|111|305|311||30.0 | 20|70|70|311|361|ST26ASA33CSA43TSA51TSG53C|355.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGACGTGAAGAAGCCTGGGTCGTCGGTGAAGGTCTCCTGCAAGACTTCT | 40 | GGAGGCTCCTTCGGCAGTTCTGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCCGCACAAGGGCTTGAGTGGATGGGAGAG | 40 | ATCATCCCTGTTTTTGATAAAGCG | 40 | AACTACGCTCAGAACTTCCAGGGCAGACTGACCATTACCGCGGACGAACTCACGGGAACAGTGTTCATGGAATTGAGTAGCCTGAGATCTGAGGACACGGCCGTGTATTTC | 40 | TGTGCGAGACTAAGGAGGGATTGGGGTGATGCATTTGATCTCTGG | 40 | GGCCTAGGGACATTCGTCACCGTCTCTTCAG | 40 | QVQLVQSGADVKKPGSSVKVSCKTS | GGSFGSSA | ISWVRQAPAQGLEWMGE | IIPVFDKA | NYAQNFQGRLTITADELTGTVFMELSSLRSEDTAVYF | CARLRRDWGDAFDLW | GLGTFVTVSS_ | ::::0:75:99:150:174:285:-2:294:305:-15:-16:311:311:0:330:361:: |
| 39 | 181 | 0.00304381 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGACGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAACTATGCAATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGGGGATCATCCCTATCGTTGGAACAGGAAGTTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAACCCACGACCACAGCCTACATGGAGCTGAGCAGCCTGAGATTTGAGGACACGGCCGTGTATTATTGTGCGAGAGTTGTTATTCTAGTACCAACTGCCTCCACTCACTACTACTACCATATGGACGTCTGGGGCCCAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2828.9) | IGHD2-2*00(51) | IGHJ6*00(483) | nan | 57|352|373|0|295|SA91GSA112CSG148AST155ASA203GST219GST224ASC229GSA232GSC233TST279CSG286CSC319TSC341T|2544.0 | 43|56|93|304|317|SG51A|51.0 | 26|83|83|325|382|SG37CSG38ASA56C|483.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGACGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAACTATGCA | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGGGG | 40 | ATCATCCCTATCGTTGGAACAGGA | 40 | AGTTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAACCCACGACCACAGCCTACATGGAGCTGAGCAGCCTGAGATTTGAGGACACGGCCGTGTATTAT | 40 | TGTGCGAGAGTTGTTATTCTAGTACCAACTGCCTCCACTCACTACTACTACCATATGGACGTCTGG | 39 | GGCCCAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVRKPGSSVTVSCKAS | GGTFSNYA | ISWVRQAPGQGLEWMGG | IIPIVGTG | SYAQKFQGRVTITADEPTTTAYMELSSLRFEDTAVYY | CARVVILVPTASTHYYYHMDVW | GPGTTVTVSS_ | ::::0:75:99:150:174:285295:304:-12:-6:317:325:-6:351:382:: |
| 40 | 167 | 0.00280837 | CAGGTTCAGCTGGTGCAATCTGGACCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACTTTTACCAATTATGGTTTCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGGCACACAAAGTATTCACAGATATTCCAGGCCAGAGTCATCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGTTGAGGAGCCTGACATCTGACGACACGGCCGTGTATTACTGTGCGAGAGAGGGGGCCGGGACTAACCCACTAGGCTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2696.6) | IGHD1-2600(35),IGHD3-2200(33),IGHD5-12*00(30) | IGHJ4*00(380) | nan | 57|353|373|0|296|SG74ASG81CSC140TSG148ASC149TSA156TSG160AST224GSA225CSC233GSG237TSA244TSG245ASC246TSG253CSC262TSC303TSG316C|2438.0 | 9|16|60|311|318||35.0;7|16|93|308|318|I10C|33.0;10|16|69|312|318||30.0 | 30|68|68|320|358||380.0 | nan | CAGGTTCAGCTGGTGCAATCTGGACCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACTTTTACCAATTATGGT | 40 | TTCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCGCTTACAATGGGCACACA | 40 | AAGTATTCACAGATATTCCAGGCCAGAGTCATCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGTTGAGGAGCCTGACATCTGACGACACGGCCGTGTATTAC | 40 | TGTGCGAGAGAGGGGGCCGGGACTAACCCACTAGGCTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGPEVKKPGASVKVSCKAS | GYTFTNYG | FNWVRQAPGQGLEWMGW | ISAYNGHT | KYSQIFQARVIMTTDTSTSTAYMELRSLTSDDTAVYY | CAREGAGTNPLGYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:0:296:311:11:-24:318:320:-10:327:358:: |
| 41 | 164 | 0.00275792 | CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCATCTACGGTATCTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGGTTACAATGGAAACACAGACTATGCACAGAACCTCCAGGACAGAGTCACCCTGACCACAGACGCATCCACGAGCTCAGTATACATGGAGCTGAGGAGCCTCAGATCTGACGACACGGCCGTCTATTACTGTGCGAGGGTCGATTACTATGATAGTAGCGGTTATTACGGATACTGGGGCCAGGGAACCCTGATCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2689.4) | IGHD3-22*00(116) | IGHJ4*00(341) | nan | 57|350|373|0|293|SG148TST152CSA159TSG160CSC214GST224ASA231GSG245CSG253ASA264CSA276GSA288TSC292TSC293ASG314CSG335C|2466.0 | 33|59|93|298|324|ST49C|116.0 | 31|68|68|327|364|SG52A|341.0 | nan | CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACCTTTACCATCTACGGT | 40 | ATCTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCGGTTACAATGGAAACACA | 40 | GACTATGCACAGAACCTCCAGGACAGAGTCACCCTGACCACAGACGCATCCACGAGCTCAGTATACATGGAGCTGAGGAGCCTCAGATCTGACGACACGGCCGTCTATTAC | 40 | TGTGCGAGGGTCGATTACTATGATAGTAGCGGTTATTACGGATACTGG | 40 | GGCCAGGGAACCCTGATCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTFTIYG | ISWVRQAPGQGLEWMGW | ISGYNGNT | DYAQNLQDRVTLTTDASTSSVYMELRSLRSDDTAVYY | CARVDYYDSSGYYGYW | GQGTLITVSS_ | ::::0:75:99:150:174:285:-3:293:298:-2:-3:324:327:-11:333:364:: |
| 42 | 160 | 0.00269066 | CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTTTGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCAGAAAACCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGATCACCGTGGTGGGACTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(3096.4) | IGHD2-1500(35),IGHD2-2100(35),IGHD1-26*00(30) | IGHJ3*00(500) | nan | 57|355|373|0|298|SA151TSC240GSG242ASG245C|2864.0 | 42|49|93|301|308||35.0;36|43|84|301|308||35.0;26|32|60|304|310||30.0 | 20|70|70|311|361||500.0 | nan | CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACCTTTACCAGCTTTGGT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCGCTTACAATGGTAACACA | 40 | AACTATGCAGAAAACCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTAC | 40 | TGTGCGAGAGATCACCGTGGTGGGACTGATGCTTTTGATATCTGG | 40 | GGCCAAGGGACAATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTFTSFG | ISWVRQAPGQGLEWMGW | ISAYNGNT | NYAENLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYY | CARDHRGGTDAFDIW | GQGTMVTVSS_ | ::::0:75:99:150:174:285:2:298:301:-11:-13:308:311:0:330:361:: |
| 43 | 160 | 0.00269066 | CAGGTGCAGGTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGTCCTCGGTGAACGTCTCTTGCAAGGCTTCTGGGGGTTACTTCAACAATCGTCAAACCCTCAACAGTTATCCTATCAGTTGGGTTCGACAGGCCCCCGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTCTCTTTGGTACAACAAACTACGCACAGAGGTTTCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACGACCTATCTGGAGTTGAACAATGTGACATCTGACGACACGGCCGTGTATTACTGTGCGAAGTCATGGGGGGGAGAGATCTACTACTACTACTACGCTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2115.5) | IGHD3-1600(35),IGHD4-1100(35),IGHD4-23*00(35) | IGHJ6*00(550) | nan | 57|349|373|0|310|SC66GSA94GSG113CSC119TSA134GSC137TI138TI138AI138CI138TI138TI138CI138AI138AI138CI138AI138AI138TI138CI138GI138TI138CI138AI138AST141CSG145ASC149TSG153CSC161TSG167TST179CSA216CSG228ASA244GSC248TSG276ASA290GSG291ASC296TSA297CSC303TSG307ASG310ASC311TSC312GSG316CSG323C|1830.0 | 54|61|111|318|325||35.0;11|18|48|310|317||35.0;14|21|57|310|317||35.0 | 22|83|83|330|391|SG38C|581.0 | nan | CAGGTGCAGGTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGTCCTCGGTGAACGTCTCTTGCAAGGCTTCT | 40 | GGGGGTTACTTCAACAATCGTCAAACCCTCAACAGTTATCCT | 40 | ATCAGTTGGGTTCGACAGGCCCCCGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTCTCTTTGGTACAACA | 40 | AACTACGCACAGAGGTTTCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACGACCTATCTGGAGTTGAACAATGTGACATCTGACGACACGGCCGTGTATTAC | 39 | TGTGCGAAGTCATGGGGGGGAGAGATCTACTACTACTACTACGCTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQVVQSGAEVKRPGSSVNVSCKAS | GGYFNNRQTLNSYP | ISWVRQAPGQGLEWMGG | IIPLFGTT | NYAQRFQGRVTITADKSTSTTYLELNNVTSDDTAVYY | CAKSWGGEIYYYYYAMDVW | GQGTTVTVSS_ | ::::0:75:117:168:192:303:-4:310:318:-17:-13:325:330:-2:360:391:: |
| 44 | 159 | 0.00267384 | CAGGTGCAGCTGGTGCAGTCTGGGACAGAGGTGAAGAAGCCTGGGTCCTCGGCGAAGGTCTCCTGCAAGGCTTCTGGAGGCACATTCAGCAACTATGTGATAAGTTGGGTGCGACAGGCCCCTGGACAAGGCCTCGAGTGGATGGGGGGGATCATCCCTCTCTTTGGGACGACTGACTATGCCAAGAAGTTCCAGGGCAGAATCGCGATTACCGCGGACGAATCCACGACCACAGTCTACATGGATTTGAGCAGCCTGAGATTTGAGGACACGGCCGTCTATTTCTGTGAAATAGATGTGGGCTCCGGGGAGTTGTCTGTCGTCTGGGGCCAAGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2304.8) | IGHD3-1600(41),IGHD3-1000(35) | IGHJ6*00(351) | nan | 57|346|373|0|289|SG81AST83AST109CSC140ASG148ASC154TST155GSC158ASC161TSG188CST191CSA203GSA216CST224GSA227GSG228ASA230TSA231GSC236TSA239CSC240ASG258ASA261GSG286CSC292TSG302TSC303TSC319TSG335CSA340T|2020.0 | 55|66|111|306|317|SA63G|41.0;47|54|93|307|314||35.0 | 45|83|83|320|358|SC71T|351.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGACAGAGGTGAAGAAGCCTGGGTCCTCGGCGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACATTCAGCAACTATGTG | 40 | ATAAGTTGGGTGCGACAGGCCCCTGGACAAGGCCTCGAGTGGATGGGGGGG | 40 | ATCATCCCTCTCTTTGGGACGACT | 40 | GACTATGCCAAGAAGTTCCAGGGCAGAATCGCGATTACCGCGGACGAATCCACGACCACAGTCTACATGGATTTGAGCAGCCTGAGATTTGAGGACACGGCCGTCTATTTC | 40 | TGTGAAATAGATGTGGGCTCCGGGGAGTTGTCTGTCGTCTGG | 40 | GGCCAAGGGACCACGGTCATCGTCTCCTCAG | 40 | QVQLVQSGTEVKKPGSSAKVSCKAS | GGTFSNYV | ISWVRQAPGQGLEWMGG | IIPLFGTT | DYAKKFQGRIAITADESTTTVYMDLSSLRFEDTAVYF | CEIDVGSGELSVVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285:-7:289:306:-18:-8:317:320:-25:327:358:: |
| 45 | 158 | 0.00265703 | CAGGTGCAGTTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAGGGTCTCCTGCAAGACTTCTGGTTACACCTTCATCAACTATGGTATCACCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGTGGCTCAGCGCCTACAATGGTGACACAAGCTCTTCAGAGAAGCTCCAGGACAGGTTCACCATGACCACAGACACATCCACGAACACAGTGTATATGGACCTGAGGAGCCTGACATCTGACGACACGGCCGTATATTACTGTGCGAGATGGAGCGCCATAGTGGGAGGTGCTGAAGCTCTTGATGTCTGGGGCCAAGGGACAATGGTCATCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2422.8) | IGHD1-26*00(50) | IGHJ3*00(384) | nan | 57|351|373|0|294|ST62GSC66TSA112GSG126AST143CSC145TSG148ASG160CSA203GSA207CST215CSA225GSA232GSA235CSG237TSC240GSG253ASA257GSG258TSG286ASC292TSC293GSC296TSG302CSG316CSG335A|2186.0 | 23|33|60|303|313||50.0 | 20|70|70|317|367|ST23AST27CSA33GSC58T|384.0 | nan | CAGGTGCAGTTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAGGGTCTCCTGCAAGACTTCT | 40 | GGTTACACCTTCATCAACTATGGT | 40 | ATCACCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGTGG | 40 | CTCAGCGCCTACAATGGTGACACA | 40 | AGCTCTTCAGAGAAGCTCCAGGACAGGTTCACCATGACCACAGACACATCCACGAACACAGTGTATATGGACCTGAGGAGCCTGACATCTGACGACACGGCCGTATATTAC | 40 | TGTGCGAGATGGAGCGCCATAGTGGGAGGTGCTGAAGCTCTTGATGTCTGG | 40 | GGCCAAGGGACAATGGTCATCGTCTCTTCAG | 40 | QVQLVQSGAEVKKPGASVRVSCKTS | GYTFINYG | ITWVRQAPGQGLEWMGW | LSAYNGDT | SSSEKLQDRFTMTTDTSTNTVYMDLRSLTSDDTAVYY | CARWSAIVGGAEALDVW | GQGTMVIVSS_ | ::::0:75:99:150:174:285:-2:294:303:-3:-7:313:317:0:336:367:: |
| 46 | 158 | 0.00265703 | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGGCCTCGGTGAAAGTCTCCTGCAAGGCCTCTGGAGGCACCTTCAGTAGGTCTGGTTTCCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATGATCGTCCCCAGTGTTGACACAACAAACTACGCACAGAAGTTCCAGGCCAGAGTCACGATTAGCGCGGACCAGTTCACGAGCACAGTCTACATGGAGTTGAGAAGCCTGAGATCTGAGGACACGGCCGTATATTATTGTGCGAGATGTCCACAGCCTCCAGATACTGCTGACCCTTACGCTGTGGACGTCTGGGGCCAAGGGACCAGGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2339.7) | IGHD6-1300(32),IGHD6-1900(32),IGHD5-5*00(31) | IGHJ6*00(374) | nan | 57|351|373|0|294|SG81AST102GSG113AST128CSC146TSC149GSA151CSC154GSA156TSA159CSG160ASG204ASG205TSA210GST215CST217GSC218TST219GSG223AST224CSG228ASG253CSC268GSG276CSA278GSC280TSC292TSC303TSC308ASG335ASC341T|2041.0 | 3|15|63|306|318|SC7ASG9A|32.0;3|15|63|306|318|SC7ASC8T|32.0;23|32|60|309|318|SA28T|31.0 | 34|83|83|324|373|SG38CSA40GSC65GSC71T|374.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGGCCTCGGTGAAAGTCTCCTGCAAGGCCTCT | 40 | GGAGGCACCTTCAGTAGGTCTGGT | 40 | TTCCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATG | 40 | ATCGTCCCCAGTGTTGACACAACA | 40 | AACTACGCACAGAAGTTCCAGGCCAGAGTCACGATTAGCGCGGACCAGTTCACGAGCACAGTCTACATGGAGTTGAGAAGCCTGAGATCTGAGGACACGGCCGTATATTAT | 39 | TGTGCGAGATGTCCACAGCCTCCAGATACTGCTGACCCTTACGCTGTGGACGTCTGG | 40 | GGCCAAGGGACCAGGGTCATCGTCTCCTCAG | 40 | QVQLVQSGTEVKKPGASVKVSCKAS | GGTFSRSG | FHWVRQAPGQGLEWMGM | IVPSVDTT | NYAQKFQARVTISADQFTSTVYMELRSLRSEDTAVYY | CARCPQPPDTADPYAVDVW | GQGTRVIVSS_ | ::::0:75:99:150:174:285:-2:294:306:18:-27:318:324:-14:342:373:: |
| 47 | 152 | 0.00255613 | CAGGTGAGGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCGAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTGTCACCTGGGTGCGGCAGGCCCCGGGACAAGGGCTTGAGTGGATGGGCGGGATCATCCCCATCGTTACTACACCAAACTACGCACAGAAGTTCCAGGGCAGACTCACGATCTCCGCGGACAAATCCACGAGCACATCTTACATGGAGTTGAGCAGCCTGAGATCGGAAGACACGGGCGTCTATTACTGTGCGAGAGTTGGTTACAACTTTTGGAGTCGTTATCACTACTACGGAATGGACGTCTGGGGCCAAGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2535.4) | IGHD3-3*00(68) | IGHJ6*00(482) | nan | 57|352|373|0|295|SC63ASA64GSA123GSA156GSG160CSA170GST179GSA203CST215CST219GSG222ASG223CSG228CSG258CST266CSA267TSG276ASG291TSC293TSC303TST320GSG323ASC331GSG335C|2254.0 | 34|56|93|299|321|SG38AST40CSG50C|68.0 | 29|83|83|322|376|ST39ASC71T|482.0 | nan | CAGGTGAGGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCGAGGCTTCT | 40 | GGAGGCACCTTCAGCAGCTATGCT | 40 | GTCACCTGGGTGCGGCAGGCCCCGGGACAAGGGCTTGAGTGGATGGGCGGG | 40 | ATCATCCCCATCGTTACTACACCA | 40 | AACTACGCACAGAAGTTCCAGGGCAGACTCACGATCTCCGCGGACAAATCCACGAGCACATCTTACATGGAGTTGAGCAGCCTGAGATCGGAAGACACGGGCGTCTATTAC | 40 | TGTGCGAGAGTTGGTTACAACTTTTGGAGTCGTTATCACTACTACGGAATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCATCGTCTCCTCAG | 40 | QVRLVQSGAEVKKPGSSVKVSCEAS | GGTFSSYA | VTWVRQAPGQGLEWMGG | IIPIVTTP | NYAQKFQGRLTISADKSTSTSYMELSSLRSEDTGVYY | CARVGYNFWSRYHYYGMDVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285295:299:-3:-6:321:322:-9:345:376:: |
| 48 | 152 | 0.00255613 | CAAGTTCAGCTGGTGCAGTCTGGAGCTGACGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAATTTTACCAGCTATGGAATCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCCCTCATAATGATAGAACAAAGTATGCACGGAGATTCCAGGACAGAGTCACCATGACCACAGAGACACCCACGAGCACAGTCTACATGGAGCTGGGGAGCCTGAGATCTGACGACACGGCCGTTTATTACTGTGCGAGAGACCTCTATTATAGCAGTGGCCGGTACTTTGATCATGATGCTTTTGATATCTGGGGCCAGGGGACAGTGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2533.6) | IGHD6-19*00(76) | IGHJ3*00(482) | nan | 57|358|373|0|301|SG59ASG86CSC139ASC140TST155ASC161TSG213CST216CSC218TSG223ASA226GSC227ASC233GSA241GSA244GSG245ASC246TSG253ASC275GST279CSC292TSA306GSG335TST353C|2314.0 | 24|42|63|303|321|ST36C|76.0 | 16|70|70|325|379|SA44GSA51G|482.0 | nan | CAAGTTCAGCTGGTGCAGTCTGGAGCTGACGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACAATTTTACCAGCTATGGA | 40 | ATCAGTTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCCCTCATAATGATAGAACA | 40 | AAGTATGCACGGAGATTCCAGGACAGAGTCACCATGACCACAGAGACACCCACGAGCACAGTCTACATGGAGCTGGGGAGCCTGAGATCTGACGACACGGCCGTTTATTAC | 40 | TGTGCGAGAGACCTCTATTATAGCAGTGGCCGGTACTTTGATCATGATGCTTTTGATATCTGG | 40 | GGCCAGGGGACAGTGGTCACCGTCTCTTCAG | 40 | QVQLVQSGADVKKPGASVKVSCKAS | GYNFTSYG | ISWVRQAPGQGLEWMGW | ISPHNDRT | KYARRFQDRVTMTTETPTSTVYMELGSLRSDDTAVYY | CARDLYYSSGRYFDHDAFDIW | GQGTVVTVSS_ | ::::0:75:99:150:174:285:5:301:303:-3:0:321:325:4:348:379:: |
| 49 | 146 | 0.00245523 | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCCTCAGCAACAATGCTATCAGCTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGCGGGATCATCCCTCTCTCTGCTACAACAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAGATCCACGAGCACAGCCTACATGGAGCTGACCAGCCTGACATCTGAGGACACGGCCGTCTATTACTGTGCGCGAGGATTTGATGATAGGGGGATTGTAGTAGTACCAGCTGCTAACCCTTGGTATTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2788.3) | IGHD2-2*00(110) | IGHJ6*00(462) | nan | 57|352|373|0|295|SG81AST141CSG148AST150ASA170CSA203CSA216CST220CSG223CSG228ASG276ASA277GSG307CSG316CSG335CSA348C|2486.0 | 36|58|93|312|334||110.0 | 31|83|83|342|394|SC33TSC36T|462.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCCTCAGCAACAATGCT | 40 | ATCAGCTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGCGGG | 40 | ATCATCCCTCTCTCTGCTACAACA | 40 | AACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAGATCCACGAGCACAGCCTACATGGAGCTGACCAGCCTGACATCTGAGGACACGGCCGTCTATTAC | 40 | TGTGCGCGAGGATTTGATGATAGGGGGATTGTAGTAGTACCAGCTGCTAACCCTTGGTATTATGGTATGGACGTCTGG | 39 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGTEVKKPGSSVKVSCKAS | GGTLSNNA | ISWVRQAPGQGLEWMGG | IIPLSATT | NYAQKFQGRVTITADRSTSTAYMELTSLTSEDTAVYY | CARGFDDRGIVVVPAANPWYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285295:312:-5:-4:334:342:-11:363:394:: |
| 50 | 145 | 0.00243841 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCGTGCACGGCTTCTGGGGGCCCCTTCAGTAGCTATGCCATCAACTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGCGTGATCACCCCCATGTTTGGAGCACCACACTACGCACAGAACTTCAAGGGCAGAATCACCATTACCGCGGACAAGTCGACGAACACGGCCTACATGGAACTGAGCAGCCTGACGTCTGGGGACACGGCCGTTTATTTCTGTGCGAGAGTGTTCACCGGTCGTTGGTTCGACCCCTGGGGCCAGGGGACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2354.6) | IGHD1-2600(30),IGHD1-700(30),IGHD3-3*00(30) | IGHJ5*00(431) | nan | 57|352|373|0|295|SC119GSA124CSA134GSA138CSC146TST155CSG160ASA185GSA203CSG205TST211CST215CSC218GST224ASA225GSG228CSA231CSG245CSC249ASG258ASG263CSG276ASA278GSC281GSG286ASA290GSG302ASG316CSA317GSA322GSG335TSA340T|2022.0 | 17|23|60|300|306||30.0;14|20|51|300|306||30.0;59|65|93|300|306||30.0 | 25|71|71|309|355|SA48G|431.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCGTGCACGGCTTCT | 40 | GGGGGCCCCTTCAGTAGCTATGCC | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAGTGGATGGGCGTG | 40 | ATCACCCCCATGTTTGGAGCACCA | 40 | CACTACGCACAGAACTTCAAGGGCAGAATCACCATTACCGCGGACAAGTCGACGAACACGGCCTACATGGAACTGAGCAGCCTGACGTCTGGGGACACGGCCGTTTATTTC | 40 | TGTGCGAGAGTGTTCACCGGTCGTTGGTTCGACCCCTGG | 40 | GGCCAGGGGACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCTAS | GGPFSSYA | INWVRQAPGQGLEWMGV | ITPMFGAP | HYAQNFKGRITITADKSTNTAYMELSSLTSGDTAVYF | CARVFTGRWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:300:3:-17:306:309:-5:324:355:: |
| 51 | 142 | 0.00238796 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCACCTATTCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGAGCCCCCCTATCTTTGGTACATCAAAGTACGCACAGAATTTTCAGGGCAGAGTCACGATCACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGATGACACGGCCGTGTATTACTGTGCGAGAGGGGGCCGGTATCCCAAATCTTCCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2915.4) | IGHD1-2600(35),IGHD1-700(35),IGHD3-3*00(35) | IGHJ6*00(560) | nan | 57|352|373|0|295|SG148CSG153TST208GSA210CST211CSG228TSC233GSG245TSC248TST266CSG323T|2631.0 | 18|25|60|299|306||35.0;15|22|51|299|306||35.0;60|67|93|299|306||35.0 | 27|83|83|317|373||560.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCACCTATTCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | AGCCCCCCTATCTTTGGTACATCA | 40 | AAGTACGCACAGAATTTTCAGGGCAGAGTCACGATCACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGATGACACGGCCGTGTATTAC | 39 | TGTGCGAGAGGGGGCCGGTATCCCAAATCTTCCTACTACTACGGTATGGACGTCTGG | 39 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSTYS | ISWVRQAPGQGLEWMGG | SPPIFGTS | KYAQNFQGRVTITADESTSTAYMELSSLRSDDTAVYY | CARGGRYPKSSYYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285295:299:2:-15:306:317:-7:342:373:: |
| 52 | 141 | 0.00237114 | CAGGTGCAGTTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCGTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGACACAGACACAAATTATGTTATCAGTTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAATGGATGGGAGGAATCTTCCCTAAATTTGGAACAACATACTCTGCCCAGAAGTTGCAGGACAGACTCACGATTACCGCGGACGAAAGTACGTCCACAGTCTACATGCAACTGAGCAGCCTGAGACTTGACGACACGGCCGTCTATTACTGTGAGGCGGAAATGACTTTTGGGAAGTTATCAGTCGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2039.2) | IGHD3-16*00(47) | IGHJ6*00(380) | nan | 57|346|373|0|289|SC66TSG86ASC104GSG107ASG136ASC140AST141GST142ASG145CSC146ASG148ASC149TSC154TSC161TSA185GSG194ASG206ASA210TST217ASC218AST224ASG228ASA231TSA235CSC236TSA239CSC248GSG253ASG258CST279ASC280GSC281TSA285TSG286CSC292TSG300CSG302AST318CSC319TSG323CSG335C|1701.0 | 51|66|111|302|317|SG54TSG58A|47.0 | 45|83|83|320|358||380.0 | nan | CAGGTGCAGTTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGTCGTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGACACAGACACAAATTATGTT | 40 | ATCAGTTGGGTGCGACAGGCCCCTGGACAGGGGCTTGAATGGATGGGAGGA | 40 | ATCTTCCCTAAATTTGGAACAACA | 40 | TACTCTGCCCAGAAGTTGCAGGACAGACTCACGATTACCGCGGACGAAAGTACGTCCACAGTCTACATGCAACTGAGCAGCCTGAGACTTGACGACACGGCCGTCTATTAC | 39 | TGTGAGGCGGAAATGACTTTTGGGAAGTTATCAGTCGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GDTDTNYV | ISWVRQAPGQGLEWMGG | IFPKFGTT | YSAQKLQDRLTITADESTSTVYMQLSSLRLDDTAVYY | CEAEMTFGKLSVVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-7:289:302:-14:-8:317:320:-25:327:358:: |
| 53 | 140 | 0.00235433 | CTGGTGCAGCTGGAGCAGTCTGAAACTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAACTCTCCTGCAAGACTTCTGGAGACTCCTTCAACGATTATGCCATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGAATCATCCCTATCTTGAATTTAGTGAGATACGCAGAGAAGTTCCAGGGCAGAGTCACCATTAGCGCGACCGACTCCACGGGCACAGCCTACTTGGAGGTGACCAGGTTGAGATCTGAGGACACGGCCACATATTATTGTGCGACTGCGACCGAGAGCACCCCCGGGGGACGTTTGGACGTGTGGGGCCTAGGGACCACGGTCTCCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(1949) | IGHD6-1300(30),IGHD6-1900(30),IGHD6-25*00(30) | IGHJ6*00(334) | nan | 57|349|373|0|292|SA58TST70ASG79ASG80ASG81ASA91GSG113ASG114CSG126ASG136ASA138TSG145ASA147GSG148ASC149TST155CSG206AST221GSG222ASG223ASA225TSC226TSC229TSA230GSA232GSC233ASC240GSG263CSC268GSG273ASA274CSA278CSA285GSA297TSC303GSG307CSC311GSC312TSG333AST334CSG335ASC341T|1702.0 | 18|24|63|309|315||30.0;18|24|63|309|315||30.0;15|21|54|309|315||30.0 | 38|83|83|319|364|SA40TSC48GSA56TSA70T|334.0 | nan | CTGGTGCAGCTGGAGCAGTCTGAAACTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAACTCTCCTGCAAGACTTCT | 40 | GGAGACTCCTTCAACGATTATGCC | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGA | 40 | ATCATCCCTATCTTGAATTTAGTG | 40 | AGATACGCAGAGAAGTTCCAGGGCAGAGTCACCATTAGCGCGACCGACTCCACGGGCACAGCCTACTTGGAGGTGACCAGGTTGAGATCTGAGGACACGGCCACATATTAT | 40 | TGTGCGACTGCGACCGAGAGCACCCCCGGGGGACGTTTGGACGTGTGG | 40 | GGCCTAGGGACCACGGTCTCCGTCTCCTCAG | 40 | LVQLEQSETEVRKPGSSVKLSCKTS | GDSFNDYA | ISWVRQAPGQGLEWMGG | IIPILNLV | RYAEKFQGRVTISATDSTGTAYLEVTRLRSEDTATYY | CATATESTPGGRLDVW | GLGTTVSVSS_ | ::::0:75:99:150:174:285:-4:292:309:3:-18:315:319:-18:333:364:: |
| 54 | 139 | 0.00233751 | CAGGTGCAACTGGTGCAGTCTGGGGCTGAGGTGAAGCAGCCTGGGTCCTCGGTGAAGGTCTCCTGCCAGGCCTCTGGAGTCACCTTCAGCAGCTTTGCAATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTCGTACACCAAACTACGCACAGAACTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGTTCAGTCTACATGGAGCTGAGCAGACTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAAGTACGGGAAGTGGCTTCCGACCTGGGACGCATAGATTCAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2824) | IGHD5-1200(35),IGHD5-1800(35),IGHD6-19*00(35) | IGHJ5*00(500) | nan | 57|351|373|0|294|SG65ASA93CSA123CST128CSG136TSA151TST155ASG222CSG228CSG245CSC287TSA288TSC292TSC311A|2534.0 | 31|38|69|303|310||35.0;31|38|69|303|310||35.0;30|37|63|303|310||35.0 | 21|71|71|332|382||500.0 | nan | CAGGTGCAACTGGTGCAGTCTGGGGCTGAGGTGAAGCAGCCTGGGTCCTCGGTGAAGGTCTCCTGCCAGGCCTCT | 40 | GGAGTCACCTTCAGCAGCTTTGCA | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATCTTTCGTACACCA | 40 | AACTACGCACAGAACTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGTTCAGTCTACATGGAGCTGAGCAGACTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGAAGTACGGGAAGTGGCTTCCGACCTGGGACGCATAGATTCAACTGGTTCGACCCCTGG | 39 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKQPGSSVKVSCQAS | GVTFSSFA | ISWVRQAPGQGLEWMGG | IIPIFRTP | NYAQNFQGRVTITADESTSSVYMELSRLRSEDTAVYY | CARSTGSGFRPGTHRFNWFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-2:294:303:-8:-8:310:332:-1:351:382:: |
| 55 | 138 | 0.00232069 | CAGGTGCAGCTGGTGCAGTCTGTGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCAAGGCTTCTGGAGACTCCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACACGGGCTTGAGTGGATGGGACGGATCATCCCTATCTTTGGCACACCAAACTACGCACAGAGGGTCGAGGGCAGAGTCACGATAACCGCGGACGAATCCACGAGCACAGCCAACATGGAACTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTATTGTGCGACTGGGGGCAATTACTATGAAACTAGTGCTTTGGCCTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2685.3) | IGHD3-22*00(63) | IGHJ4*00(380) | nan | 57|349|373|0|292|SG79TSG110TSG136ASA138TSA185CSG204CST224CSG228CSA244GST246GSC249GST266AST294ASG302ASG323CSG335CSC341T|2427.0 | 33|54|93|301|322|ST43ASG45CSG51C|63.0 | 30|68|68|326|364||380.0 | nan | CAGGTGCAGCTGGTGCAGTCTGTGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGACTCCTTCAGCAGCTATGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACACGGGCTTGAGTGGATGGGACGG | 40 | ATCATCCCTATCTTTGGCACACCA | 40 | AACTACGCACAGAGGGTCGAGGGCAGAGTCACGATAACCGCGGACGAATCCACGAGCACAGCCAACATGGAACTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTAT | 39 | TGTGCGACTGGGGGCAATTACTATGAAACTAGTGCTTTGGCCTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSVAEVKKPGSSVKVSCKAS | GDSFSSYA | ISWVRQAPGHGLEWMGR | IIPIFGTP | NYAQRVEGRVTITADESTSTANMELSSLRSDDTAVYY | CATGGNYYETSALAYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-4:292:301:-2:-8:322:326:-10:333:364:: |
| 56 | 138 | 0.00232069 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCCCCTTCAGCAACTATGCTATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTACCTTTACTACAGGGATCATCCCTATCTTTGGTACACCAACCTACGCACAGAACTTCCAGGGCAGAGTCACCATTACCGCGGACGAATCCACGAGTACAGCCTACATGGAGCTGAGTAGCCTGAGATCTGACGACACGGCCGTCTATTACTGTGCGAGAGATGTTTTGGTCGGATACAGCAGTGGCTGGCATTCCTATCGTAATTCTGTAGGTGGAATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2604.3) | IGHD6-19*00(67) | IGHJ6*00(431) | nan | 57|354|373|0|321|SA138CSG148ASG160AI217CI217CI217TI217TI217TI217AI217CI217TI217AI217CI217AI217GI217GI217GI217AI217TI217CI217AI217TI217CI217CI217CI217TI217ASG228CSA232CSG245CSG263CSC287TSC308TSG323CSG335C|2336.0 | 20|39|63|329|348|SG23AST26C|67.0 | 37|83|83|372|418|ST39A|431.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCCCCTTCAGCAACTATGCT | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTACCTTTACTACAGGGATCATCCCTATCTTTGGTACACCA | 40 | ACCTACGCACAGAACTTCCAGGGCAGAGTCACCATTACCGCGGACGAATCCACGAGTACAGCCTACATGGAGCTGAGTAGCCTGAGATCTGACGACACGGCCGTCTATTAC | 40 | TGTGCGAGAGATGTTTTGGTCGGATACAGCAGTGGCTGGCATTCCTATCGTAATTCTGTAGGTGGAATGGACGTCTGG | 39 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGPFSNYA | INWVRQAPGQGLEWMGG | IIPTFTTGIIPIFGTP | TYAQNFQGRVTITADESTSTAYMELSSLRSDDTAVYY | CARDVLVGYSSGWHSYRNSVGGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:198:309:1:321:329:1:-3:348:372:-17:387:418:: |
| 57 | 138 | 0.00232069 | CAGGTGCAGCTGGTGCAGTCTGGGGCCGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCATCCGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACTGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTGATGGTGGTGGCACTAGCTACGCACAGCAATTCCAGGGCAGAGTCATCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGATGAGCAGCCTGAGATCTGAAGACACGGCCGTGTATTACTGCGCCGTCGGCGGTAACTACTTAAGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-46*00(3060.6) | IGHD4-2300(26),IGHD1-700(25),IGHD3-3*00(25) | IGHJ6*00(453) | nan | 57|347|373|0|290|ST83CST116CST131CSA172TSA216GSG217ASA225GSA230TSA243CSG245ASC262TSC303ASG323AST344C|2494.0 | 25|33|57|293|301|ST28C|26.0;16|21|51|296|301||25.0;61|66|93|296|301||25.0 | 29|83|83|301|355|SA35TSC36ASG37A|453.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCCGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCATCC | 40 | GGATACACCTTCACCAGCTACTAT | 40 | ATGCACTGGGTGCGACTGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATA | 40 | ATCAACCCTGATGGTGGTGGCACT | 40 | AGCTACGCACAGCAATTCCAGGGCAGAGTCATCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGATGAGCAGCCTGAGATCTGAAGACACGGCCGTGTATTAC | 39 | TGCGCCGTCGGCGGTAACTACTTAAGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTFTSYY | MHWVRLAPGQGLEWMGI | INPDGGGT | SYAQQFQGRVIMTRDTSTSTVYMEMSSLRSEDTAVYY | CAVGGNYLSMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-6:290:293:-6:-5:301:301:-9:324:355:: |
| 58 | 136 | 0.00228706 | CAGCTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGGAACCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCACCTCTTCTTTCGTCTGGGTGCGACAGGGCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTCACTAGGACAAATTTCGCACAGAAGTTCCAGGGCAGAGTCACCTTTAGCGCGGACGAATCCACGCGAACAACCTACATGGAACTGCGCAGCCTGACATCTGAGGACACGGCCATATATTACTGTGCGAGAGACGTGGTGCGGTCTACTGCGGGGGACTCCTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2341.2) | IGHD2-15*00(38) | IGHJ400(342),IGHJ500(342) | nan | 57|353|373|0|296|SG60CSG81ASA93GSG95ASG148CSA151CSG153TSA156TSA159GSG160TSC175GST221CSG222ASG223CSC226GSA227GSG228ASC233TSA235TSG263CSA264TSC268GSA285CSC287ASG291ASG302ASA306CSG316CSG333ASG335A|2090.0 | 45|64|93|297|316|DA50ST53GI55TSC60G|38.0 | 28|68|68|318|358|SA32CSC63T|342.0;31|71|71|318|358|SC34TSC66T|342.0 | nan | CAGCTGCAGCTGGTGCAGTCTGGGACTGAGGTGAAGGAACCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCACCTCTTCT | 40 | TTCGTCTGGGTGCGACAGGGCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATCTTCACTAGGACA | 40 | AATTTCGCACAGAAGTTCCAGGGCAGAGTCACCTTTAGCGCGGACGAATCCACGCGAACAACCTACATGGAACTGCGCAGCCTGACATCTGAGGACACGGCCATATATTAC | 40 | TGTGCGAGAGACGTGGTGCGGTCTACTGCGGGGGACTCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCTTCAG | 40 | QLQLVQSGTEVKEPGSSVKVSCKAS | GGTFSTSS | FVWVRQGPGQGLEWMGG | IIPIFTRT | NFAQKFQGRVTFSADESTRTTYMELRSLTSEDTAIYY | CARDVVRSTAGDSW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:0:296:297:-14:2:316:318:-8:327:358:: |
| 59 | 135 | 0.00227024 | CAGGTACTATTGGTACAGTCTGGGGCTGACGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGACTTCTGGATACACATTCACCGAATTCGATATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAATGGATGGGATGGATGAACACTAATACTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTTACCATGACCAGGGACACCTCCATCAGCACAGCCTACATGGAGCTGAGAAGACTGAGATCTGAGGACACGGCCGTCTATTATTGTGCGAGAGTGGTCCGCTTTTTTGGCGGGCACGCCGGCTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-8*00(2478.3) | IGHD3-3*00(35) | IGHJ4*00(380) | nan | 57|352|373|0|295|SG62ASA64TSG65ASC66TSG71ASG86CSG126ASC140ASA147GSG148AST149ASA151TST152CSA177CSG194ASC213ASC218TSG220CSC260TSA273GSA284CSC308ASC311ASG335CSC341T|2225.0 | 40|47|93|304|311||35.0 | 30|68|68|323|361||380.0 | nan | CAGGTACTATTGGTACAGTCTGGGGCTGACGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGACTTCT | 40 | GGATACACATTCACCGAATTCGAT | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAATGGATGGGATGG | 40 | ATGAACACTAATACTGGTAACACA | 40 | GGCTATGCACAGAAGTTCCAGGGCAGAGTTACCATGACCAGGGACACCTCCATCAGCACAGCCTACATGGAGCTGAGAAGACTGAGATCTGAGGACACGGCCGTCTATTAT | 40 | TGTGCGAGAGTGGTCCGCTTTTTTGGCGGGCACGCCGGCTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVLLVQSGADVKKPGASVKVSCKTS | GYTFTEFD | INWVRQAPGQGLEWMGW | MNTNTGNT | GYAQKFQGRVTMTRDTSISTAYMELRRLRSEDTAVYY | CARVVRFFGGHAGYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:304:-9:-15:311:323:-10:330:361:: |
| 60 | 134 | 0.00225343 | CAGGTGCACCTGGTGGAATCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAACGTCTGGATTCACATTCACCAATTATGTCATGCACTGGGTCCGCCAGACTCCAGGCAAGGGGCTGGAGTGGGTGGCAAATGTTTGGTATGATGGAAGACAAAAATGGTATGCAGACTTAGCGAAGGGCCGATTCACCATCTCCAGGGACAACTCCGAGAACACGGTGTCTCTACAAATGAACAGCCTGAGAGTCGAGGACACGGCTGTATATTATTGTGCGACAGAGCCCGTTGAGTCAATCTGGAGGATTGGCAGCTGGGGGATTGACAACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-33*00(2118.8) | IGHD2-200(40),IGHD6-1300(40),IGHD3-16*00(35) | IGHJ4*00(391) | nan | 57|353|373|0|296|SG65CSG74ASG126ASC140ASG145CST146CSG148ASC149TSG154TSG174ASG204AST205ASA207GSA209TST224ASA225CST227ASA232GSC233GSC244TSC245AST247CSA272GST278CSA282GSC291GSA295CSG299ASC319TSG335ASC341TSG349C|2032.0 | 6|14|93|322|330||40.0;31|39|63|322|330||40.0;53|60|111|327|334||35.0 | 26|68|68|334|376|ST31A|391.0 | nan | CAGGTGCACCTGGTGGAATCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAACGTCT | 40 | GGATTCACATTCACCAATTATGTC | 39 | ATGCACTGGGTCCGCCAGACTCCAGGCAAGGGGCTGGAGTGGGTGGCAAAT | 40 | GTTTGGTATGATGGAAGACAAAAA | 40 | TGGTATGCAGACTTAGCGAAGGGCCGATTCACCATCTCCAGGGACAACTCCGAGAACACGGTGTCTCTACAAATGAACAGCCTGAGAGTCGAGGACACGGCTGTATATTAT | 40 | TGTGCGACAGAGCCCGTTGAGTCAATCTGGAGGATTGGCAGCTGGGGGATTGACAACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVHLVESGGGVVQPGRSLRLSCATS | GFTFTNYV | MHWVRQTPGKGLEWVAN | VWYDGRQK | WYADLAKGRFTISRDNSENTVSLQMNSLRVEDTAVYY | CATEPVESIWRIGSWGIDNW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:0:296:322:25:-48:330:334:-6:345:376:: |
| 61 | 133 | 0.00223661 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGTAGCTATACTTTCAGCTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGAGGGATCGTCCCTCTCTTTGGTACAACAAACGACGCAAAGATTTTTCAGGGCAGAGTCACGATTTCCGCGGACGAATCCACGAGCACAGTGTACATGGAGCTGAGCAGCCTCAGATCTGAAGACTCGGCCATGTATTATTGTGCGAGAGATGGCGATGTTACGTCAACTCGTCCCAGAGGTGCTTTTGATATCTGGGGCCAAGGGACAGTGATCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2625.9) | IGHD5-500(38),IGHD5-1200(36),IGHD6-6*00(36) | IGHJ3*00(412) | nan | 57|354|373|0|297|SG107ASC146TSG153ASA156TSG188ASA210GSA216CSG228AST234GSC240ASA244TSG245TSC248TSA267TSC292TSC293GSG314CSG323ASA327TSG333ASC341T|2361.0 | 35|45|60|303|314|I42C|38.0;42|54|69|304|318|I48CI50C|36.0;26|36|54|310|320|SG28A|36.0 | 23|70|70|326|373|SA51GSG54A|412.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGTAGCTATACT | 40 | TTCAGCTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGAGGG | 40 | ATCGTCCCTCTCTTTGGTACAACA | 40 | AACGACGCAAAGATTTTTCAGGGCAGAGTCACGATTTCCGCGGACGAATCCACGAGCACAGTGTACATGGAGCTGAGCAGCCTCAGATCTGAAGACTCGGCCATGTATTAT | 39 | TGTGCGAGAGATGGCGATGTTACGTCAACTCGTCCCAGAGGTGCTTTTGATATCTGG | 40 | GGCCAAGGGACAGTGATCACCGTCTCTTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSSYT | FSWVRQAPGQGLEWMGG | IVPLFGTT | NDAKIFQGRVTISADESTSTVYMELSSLRSEDSAMYY | CARDGDVTSTRPRGAFDIW | GQGTVITVSS_ | ::::0:75:99:150:174:285:1:297:303:-15:5:314:326:-3:342:373:: |
| 62 | 132 | 0.00221979 | CAGGTTCAACTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAAACTTCTGGTTACACCTTTACCAACCACGGAATCAACTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGATGGATCAATCCTTACAATGCTAATGTGAACTATGCACAGAAACTCCAGGGCCGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGACCTGAGGAGCCTGACATCTGACGACACGGCCGTCTATTACTGTGCGAGAGATCGAGTCGCGGGAATTTGGGGGGATGCTTTTGATATCTGGGGCCAGGGGACAATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2598.3) | IGHD3-16*00(45) | IGHJ3*00(461) | nan | 57|355|373|0|298|SG65ASG125ASG126ASG148AST150CST152CST155ASG160AST179ASG211ASC212TSG213CSG223CSC227TSA228GSC229TSA230GSG245ASA255CSG302CSG316CSG335C|2342.0 | 50|59|111|309|318||45.0 | 21|70|70|318|367|SA44G|461.0 | nan | CAGGTTCAACTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAAACTTCT | 40 | GGTTACACCTTTACCAACCACGGA | 40 | ATCAACTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAATCCTTACAATGCTAATGTG | 40 | AACTATGCACAGAAACTCCAGGGCCGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGACCTGAGGAGCCTGACATCTGACGACACGGCCGTCTATTAC | 40 | TGTGCGAGAGATCGAGTCGCGGGAATTTGGGGGGATGCTTTTGATATCTGG | 40 | GGCCAGGGGACAATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKTS | GYTFTNHG | INWVRQAPGQGLEWMGW | INPYNANV | NYAQKLQGRVTMTTDTSTSTAYMDLRSLTSDDTAVYY | CARDRVAGIWGDAFDIW | GQGTMVTVSS_ | ::::0:75:99:150:174:285:2:298:309:-13:-15:318:318:-1:336:367:: |
| 63 | 132 | 0.00221979 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAGGGTCTCCTGCAAGGCTTCTGGAGGCACCCTCAATAGCTACACTATCAGTTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGGGATCATCCCTGTCTTCGGGACAACAGACTACGCACAGAAGTTCCAGGGCAGAGTCACAATTACCGCGGACCAGTCCACGGGCACAGCCTACCTGGATCTCTTCAGCCTGAGATCTGAGGACACGGCCATATATTACTGCTCGATCAGCAACTCATACGGTCGTGGGGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2450.4) | IGHD4-2300(31),IGHD4-1700(30),IGHD6-6*00(29) | IGHJ4*00(371) | nan | 57|344|373|0|287|SA112GST141CSG145ASC146TST152CSG153ASC161TSG188CSA216GST221CST224GSG228ASA231GSG263ASG276CSA278GSA285GSA297CSG302TSG305CSA306TSG307TSG333ASG335A|2174.0 | 23|32|57|303|312|SG29C|31.0;20|26|48|303|309||30.0;24|41|54|294|311|SG28ASG32ASC34ASA38T|29.0 | 28|68|68|315|355|SA32T|371.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAGGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCCTCAATAGCTACACT | 40 | ATCAGTTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTGTCTTCGGGACAACA | 40 | GACTACGCACAGAAGTTCCAGGGCAGAGTCACAATTACCGCGGACCAGTCCACGGGCACAGCCTACCTGGATCTCTTCAGCCTGAGATCTGAGGACACGGCCATATATTAC | 39 | TGCTCGATCAGCAACTCATACGGTCGTGGGGACTTCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVRVSCKAS | GGTLNSYT | ISWVRQAPGQGLEWMGG | IIPVFGTT | DYAQKFQGRVTITADQSTGTAYLDLFSLRSEDTAIYY | CSISNSYGRGDFW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:-9:287:303:-4:-6:312:315:-8:324:355:: |
| 64 | 132 | 0.00221979 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGTTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGAACTACCACAGACTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACATACTACATGGAACTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGACCCCAGATCGCCAGCCACTACTATTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-46*00(3214.7) | IGHD7-2700(31),IGHD6-1900(30) | IGHJ6*00(541) | nan | 57|351|373|0|294|SC149TST221ASG222ASG223CSG226CSA231GSG232ASG291TST292ASG302A|2650.0 | 20|29|33|299|308|SC24G|31.0;3|9|63|304|310||30.0 | 26|83|83|310|367|SC33T|541.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCT | 40 | GGATACACCTTCACCAGTTACTAT | 40 | ATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATA | 40 | ATCAACCCTAGTGGAACTACCACA | 40 | GACTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACATACTACATGGAACTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGACCCCAGATCGCCAGCCACTACTATTACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTFTSYY | MHWVRQAPGQGLEWMGI | INPSGTTT | DYAQKFQGRVTMTRDTSTSTYYMELSSLRSEDTAVYY | CARPQIASHYYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-2:294:299:-9:7:308:310:-6:336:367:: |
| 65 | 132 | 0.00221979 | GAGGTGCAGCTGTTGGAATCTGGGGGAGGCTTGGTACAGCCGGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGGCATGACCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATTTAGTAGTGCTACTGGTGCTGGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATTTCCAGAGACAATTCCAAAAACACGCTGTATCTGCAAATGACCAGCCTGAGAGCCGACGACACGGCCGTCTATTATTGTGCGAAGGATCGCCGGGCAGGGGGGAACTATGGCTTTTATTCCGACTTCTGGGGCCAGGGAGCCCTGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-23*00(2553.5) | IGHD1-700(35),IGHD3-1000(35),IGHD3-22*00(30) | IGHJ4*00(313) | nan | 57|355|373|0|298|SG74AST98GSC154GSG160CSG204TSC205TST208GSG214CSG217CSG223CSA225GSC266TSG284ASA307CSG323CSA335CSC341TSA350G|2458.0 | 26|33|51|310|317||35.0;36|43|93|313|320||35.0;36|42|93|313|319||30.0 | 28|68|68|330|370|SA32TSA46GSC56T|313.0 | nan | GAGGTGCAGCTGTTGGAATCTGGGGGAGGCTTGGTACAGCCGGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCT | 40 | GGATTCACCTTTAGCAGCTATGGC | 40 | ATGACCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATTT | 40 | AGTAGTGCTACTGGTGCTGGCACA | 40 | TACTACGCAGACTCCGTGAAGGGCCGGTTCACCATTTCCAGAGACAATTCCAAAAACACGCTGTATCTGCAAATGACCAGCCTGAGAGCCGACGACACGGCCGTCTATTAT | 40 | TGTGCGAAGGATCGCCGGGCAGGGGGGAACTATGGCTTTTATTCCGACTTCTGG | 40 | GGCCAGGGAGCCCTGGTCATCGTCTCCTCAG | 40 | EVQLLESGGGLVQPGGSLRLSCAAS | GFTFSSYG | MTWVRQAPGKGLEWVSF | SSATGAGT | YYADSVKGRFTISRDNSKNTLYLQMTSLRADDTAVYY | CAKDRRAGGNYGFYSDFW | GQGALVIVSS_ | ::::0:75:99:150:174:285:2:298:310:-9317:330:-8:339:370:: |
| 66 | 130 | 0.00218616 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCAAGATTTCTGGAGGCACCTTCACCAACTATGTTATCAGTTGGCTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGCTCATCCCTATCTTTGGGGCAGCAAATCTCGCACAGAAGTTCCAGGGCAGAGTCACGATAACCGCGGACGAATCCACGAGCACAGTCAACATGGAGTTGAGCAGCCTCACATCTGAGGACACGGCCGTCTACTACTGTGCGAGAGGCAGATCGTCTCCCAACTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2547.6) | IGHD6-6*00(36) | IGHJ5*00(430) | nan | 57|352|373|0|295|SA91GSG110TSG126ASC127TSG145CSG148ASC154TSC161TSG165CSA207CST224GSA225GSC233TST234CSA235TST266ASC292TST294ASC303TSG314CSG316CSG335CST338C|2283.0 | 25|35|54|295|305|SC29A|36.0 | 28|71|71|312|355||430.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTTAAGGTCTCCTGCAAGATTTCT | 40 | GGAGGCACCTTCACCAACTATGTT | 40 | ATCAGTTGGCTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | CTCATCCCTATCTTTGGGGCAGCA | 40 | AATCTCGCACAGAAGTTCCAGGGCAGAGTCACGATAACCGCGGACGAATCCACGAGCACAGTCAACATGGAGTTGAGCAGCCTCACATCTGAGGACACGGCCGTCTACTAC | 39 | TGTGCGAGAGGCAGATCGTCTCCCAACTTCGACCCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVRKPGSSVKVSCKIS | GGTFTNYV | ISWLRQAPGQGLEWMGG | LIPIFGAA | NLAQKFQGRVTITADESTSTVNMELSSLTSEDTAVYY | CARGRSSPNFDPW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:295:-7305:312:-8:324:355:: |
| 67 | 127 | 0.00213571 | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGCTGAAGAAGCCTGGGGCCTCAGTGAACATTTCCTGCACGGCTTCTGGATTCACCTTCAGTGACAATCTTATAAATTGGGTGCGCCAAGTCCCCGGACAAGGCCTTGAGTGGATGGGATGGCTCAACCCTGACACTGGAAACACAAGATATTCAGAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACCCATCCGCGAGCATAGCCTACTTGGAACTGAGCGGCCTGGAAAATGAAGACACGGCTCTCTATTTCTGTGCGAGAGACATACAGAGCGTCGGCCCGCGGGCGAATGATGCTTTTGATGTCTGGGGCCAAGGGACCATGATCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(1985.8) | IGHD2-800(30),IGHD5-500(30) | IGHJ3*00(423) | nan | 57|353|373|0|296|SG65ASG71CSG87CSG113CSG114ASA124CSA136TSC145GSA147GSG148AST150ASG153CSC154TSG158ASC159ASG173ASC175TSA186GSG188CSA207CSG213CSG217ASA220CST224ASA232GSC240GSA244CSA267TSG273CSA276CSC289TSA297TSG302ASA309GSA315GSG316AST318ASC319ASG333CSG335CSA340T|1771.0 | 7|13|93|296|302||30.0;24|30|60|297|303||30.0 | 19|70|70|322|373|SA33GSA50CSG54A|423.0 | nan | CAGGTCCAACTTGTCCAGTCTGGGGCTGAGCTGAAGAAGCCTGGGGCCTCAGTGAACATTTCCTGCACGGCTTCT | 40 | GGATTCACCTTCAGTGACAATCTT | 40 | ATAAATTGGGTGCGCCAAGTCCCCGGACAAGGCCTTGAGTGGATGGGATGG | 40 | CTCAACCCTGACACTGGAAACACA | 40 | AGATATTCAGAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACCCATCCGCGAGCATAGCCTACTTGGAACTGAGCGGCCTGGAAAATGAAGACACGGCTCTCTATTTC | 40 | TGTGCGAGAGACATACAGAGCGTCGGCCCGCGGGCGAATGATGCTTTTGATGTCTGG | 40 | GGCCAAGGGACCATGATCACCGTCTCTTCAG | 40 | QVQLVQSGAELKKPGASVNISCTAS | GFTFSDNL | INWVRQVPGQGLEWMGW | LNPDTGNT | RYSETFQGRVTISRHPSASIAYLELSGLENEDTALYF | CARDIQSVGPRANDAFDVW | GQGTMITVSS_ | ::::0:75:99:150:174:285:0:296:296:24:-49:302:322:1:342:373:: |
| 68 | 127 | 0.00213571 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCGCCTTCAGCAGCTTTGATATCAGCTGGGTGCGACAGGCCCCTGGACTAGGGCTTGAGTGGATGGGAGGGTCCATCCCTGTACTTGGAACAACAAGCTATGCACAGAAGTTCCAGGGCAGAATCACGATTACCGCGGACGCATCCACGAGGACAGCCCACATGGAGCTGTACAGTCTGAGACCTGACGACACGGCCATTTATTACTGTGCGAGAGCGAGGGCCGAGCGCGAACGTTCTTACGACTTTTGGGGTGGCTCATTTGACTCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2519.8) | IGHD3-3*00(62) | IGHJ4*00(401) | nan | 57|352|373|0|295|SA138GSA151TSC154ASA184TSA207TST208CSA216GSC218AST219CST224ASG228ASA232GSC236TSG258ASA277CSC287GST294CSA306TSG307ASC311TST318CSG323CSG333ASG335T|2254.0 | 34|52|93|317|335|ST40CSA47G|62.0 | 25|68|68|339|382|SA32C|401.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCGCCTTCAGCAGCTTTGAT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACTAGGGCTTGAGTGGATGGGAGGG | 40 | TCCATCCCTGTACTTGGAACAACA | 40 | AGCTATGCACAGAAGTTCCAGGGCAGAATCACGATTACCGCGGACGCATCCACGAGGACAGCCCACATGGAGCTGTACAGTCTGAGACCTGACGACACGGCCATTTATTAC | 40 | TGTGCGAGAGCGAGGGCCGAGCGCGAACGTTCTTACGACTTTTGGGGTGGCTCATTTGACTCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGAFSSFD | ISWVRQAPGLGLEWMGG | SIPVLGTT | SYAQKFQGRITITADASTRTAHMELYSLRPDDTAIYY | CARARAERERSYDFWGGSFDSW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:317:-3:-10:335:339:-5:351:382:: |
| 69 | 126 | 0.00211889 | CAGGTGCGATTGGTGCAGTCTGGGGCTGAGGTGAAGGAGCCTGGAGACTCAGTGAGGGTCTCCTGCGAGGCTTCTGGATACACTTTCACCGCCTACCATATACACTGGGTGCGGCAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGGATCAACCCTAAGTTTGGTGACACAGGCTATGCACAAGACTTTCAGGGCAGGGTCTCCATGACCAGCGACATGTCCATCAGCACAGTCTACATGGAGTTGAGCAGGCTGACCTCTGACGACACGGCCATATATTACTGTGCGAGAAATATGGACTATTATTATGGTCGGGGCAGCGGCAACGGACATGGTGTCTGGGGCCAAGGGACCACGGTCACCGTCTTCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHHHHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-2*00(2338.9) | IGHD3-1000(46),IGHD6-2500(46) | IGHJ6*00(341) | nan | 57|354|373|0|297|SA64GSG65ASC66TSA93GSG101ASC103ASA112GSA123GSC140TSG148CST153CSG158ASA170GSG188ASC218GSA219TSG220TSG226ASA231GSA232GSG242ASA243GSG245CST255ASA261TSG272CSC277TSC292TSC303TSG316CSA317CSG333ASG335ASG351A|1984.0 | 32|44|93|303|315|SC37T|46.0;25|37|54|319|331|ST33A|46.0 | 46|83|83|339|376|SC77T|341.0 | nan | CAGGTGCGATTGGTGCAGTCTGGGGCTGAGGTGAAGGAGCCTGGAGACTCAGTGAGGGTCTCCTGCGAGGCTTCT | 40 | GGATACACTTTCACCGCCTACCAT | 40 | ATACACTGGGTGCGGCAGGCCCCTGGACAAGGACTTGAGTGGATGGGATGG | 40 | ATCAACCCTAAGTTTGGTGACACA | 40 | GGCTATGCACAAGACTTTCAGGGCAGGGTCTCCATGACCAGCGACATGTCCATCAGCACAGTCTACATGGAGTTGAGCAGGCTGACCTCTGACGACACGGCCATATATTAC | 40 | TGTGCGAGAAATATGGACTATTATTATGGTCGGGGCAGCGGCAACGGACATGGTGTCTGG | 39 | GGCCAAGGGACCACGGTCACCGTCTTCTCAG | 40 | QVRLVQSGAEVKEPGDSVRVSCEAS | GYTFTAYH | IHWVRQAPGQGLEWMGW | INPKFGDT | GYAQDFQGRVSMTSDMSISTVYMELSRLTSDDTAIYY | CARNMDYYYGRGSGNGHGVW | GQGTTVTVFS_ | ::::0:75:99:150:174:285:1:297:303:-1:-18:315:339:-26:345:376:: |
| 70 | 126 | 0.00211889 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCCTCTGGATACAGCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCGGGACAAGGGCTTGAGTGGATGGGATGGATCATCCCTCATAGTGGTGAGACAAACTATGCACAGAAGTTTCAGGCCAGGGTCACCCTGACCAGGGACACGTCCATCAGCACAGCCTACATGCAGCTGAGCGGACTGACATCTGACGACACGGCCGTGTATTACTGTGCGAGAGAGACCGATGACTTCACTAACGGGGCCCATGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-2*00(2828.6) | IGHD4-1100(42),IGHD4-400(42) | IGHJ5*00(371) | nan | 57|353|373|0|296|SA94GST128CSC139GST179GSA211TSA216CSC218TSG226ASC227GSG253CST255ASA264CSG300CSA309GSG311ASG316C|2496.0 | 15|29|48|301|315|SA21TSG24C|42.0;15|29|48|301|315|SA21TSG24C|42.0 | 31|71|71|324|364|SC35T|371.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAGGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCCTCT | 40 | GGATACAGCTTCACCGGCTACTAT | 40 | ATGCACTGGGTGCGACAGGCCCCGGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCATCCCTCATAGTGGTGAGACA | 40 | AACTATGCACAGAAGTTTCAGGCCAGGGTCACCCTGACCAGGGACACGTCCATCAGCACAGCCTACATGCAGCTGAGCGGACTGACATCTGACGACACGGCCGTGTATTAC | 39 | TGTGCGAGAGAGACCGATGACTTCACTAACGGGGCCCATGACCTCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKRPGASVKVSCKAS | GYSFTGYY | MHWVRQAPGQGLEWMGW | IIPHSGET | NYAQKFQARVTLTRDTSISTAYMQLSGLTSDDTAVYY | CARETDDFTNGAHDLW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:0:296:301:1:-3:315:324:-11:333:364:: |
| 71 | 126 | 0.00211889 | CAGGCTCAGTTGGTCCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAACGTCTCCTGCAAGGCTTCTGGTTACGACTATGTGACCTATGCTATCACGTGGGTGCGACAAAGGCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCACTCTCAATGGGAACACAAACTACGCACAGAATTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGAATAGTCCACTTGGAGCTGAGGAGTCTGAGATCTGACGACACGGCCGTTTACTACTGTGCGAGAAGGGTACAGGTGTGGTTGCCAGATTATTACGGCATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2201.3) | IGHD5-5*00(38) | IGHJ6*00(462) | nan | 57|351|373|0|294|ST61CSC66TSG71CSG113CSA138GSC139AST142ASA144GSC145TSC146GSG148CSG154CSG160CSC161GSG173ASG174ASC175GSC176GSG213AST216CSA217TST224GST236CSG245TSC246TSC287ASC289TSC292TST294CSA297TSC311TSG335TST338C|1983.0 | 22|38|60|295|311|SA24GSC30GSA32G|38.0 | 31|83|83|318|370|SC33TST39C|462.0 | nan | CAGGCTCAGTTGGTCCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAACGTCTCCTGCAAGGCTTCT | 40 | GGTTACGACTATGTGACCTATGCT | 40 | ATCACGTGGGTGCGACAAAGGCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCACTCTCAATGGGAACACA | 40 | AACTACGCACAGAATTTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGAATAGTCCACTTGGAGCTGAGGAGTCTGAGATCTGACGACACGGCCGTTTACTAC | 40 | TGTGCGAGAAGGGTACAGGTGTGGTTGCCAGATTATTACGGCATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QAQLVQSGAEVKKPGASVNVSCKAS | GYDYVTYA | ITWVRQRPGQGLEWMGW | ISTLNGNT | NYAQNFQGRVTMTTDTSTRIVHLELRSLRSDDTAVYY | CARRVQVWLPDYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-2:294:295:-2:-2:311:318:-11:339:370:: |
| 72 | 125 | 0.00210208 | CAGGTCCACCTGGTGCAATCTGGGGCTGAGCTGAAGAGGCCTGGGTCCTCGGTGAGGCTCTCCTGCAAGGCCTCTGGAGGCACCTTCAGCATCTTTGCTATCAATTGGGTGCGCCAGGCCCCTGGACAAGGGTTTGAGTGGATGGGAGGGATCATCCCTCGGTTTAATAAAGTTAGCTTTCCAGAGAAGTTCCAGGGAAGAGTCACCTTTACCGCCGACGAATCCACCACTACAGCTTATATGGACTTGACCCGCCTGGGCTTTGAAGACACGGCCACATACTTTTGTGCGAGAGATAAAGGAGGCACACGGGGATACAGTGGCTACGACGCCTTTGACTCTTGGGGCCAGGGGACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(1816) | IGHD5-12*00(82) | IGHJ4*00(353) | nan | 57|354|373|0|297|SG62CSG65CSG74ASG87CSA94GSA112GSG114CST128CSG148TSA151TSG160ASC161TSA170CSC189TSA216CST217GSC218GSG222ASG223ASC226ASC229TSA230TSA232GSA235TSC236TSG237CSC240GSC254ASG263CSA264TSG272CSG284CSG286CSC287TSC293TSC296TSG302CSC303TSG307CSA309CSA315GSA317CSC319TSG323ASG333AST334CSG335AST338CSA340TSC341T|1520.0 | 20|42|69|307|329|ST24GST30C|82.0 | 24|68|68|332|376|SA32CSC33TSA45G|353.0 | nan | CAGGTCCACCTGGTGCAATCTGGGGCTGAGCTGAAGAGGCCTGGGTCCTCGGTGAGGCTCTCCTGCAAGGCCTCT | 40 | GGAGGCACCTTCAGCATCTTTGCT | 40 | ATCAATTGGGTGCGCCAGGCCCCTGGACAAGGGTTTGAGTGGATGGGAGGG | 40 | ATCATCCCTCGGTTTAATAAAGTT | 40 | AGCTTTCCAGAGAAGTTCCAGGGAAGAGTCACCTTTACCGCCGACGAATCCACCACTACAGCTTATATGGACTTGACCCGCCTGGGCTTTGAAGACACGGCCACATACTTT | 40 | TGTGCGAGAGATAAAGGAGGCACACGGGGATACAGTGGCTACGACGCCTTTGACTCTTGG | 40 | GGCCAGGGGACCCTGGTCACCGTCTCCTCAG | 40 | QVHLVQSGAELKRPGSSVRLSCKAS | GGTFSIFA | INWVRQAPGQGFEWMGG | IIPRFNKV | SFPEKFQGRVTFTADESTTTAYMDLTRLGFEDTATYF | CARDKGGTRGYSGYDAFDSW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:1:297:307:3:-4:329:332:-4:345:376:: |
| 73 | 123 | 0.00206844 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTTCTGCAAGGCCTCTGGAGGCACCTTCAGCAACTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTGTCTTTGGAACAACAGACTACGAACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGGATCCACGAGCACAGCCTACATGAAGCTGAGCAGCCTGAGATCTGCGGACACGGCCGTGTATTATTGTGCGAGATCCTCCCCCTATATAGTAGTACGAAAACCTACTGGGAACCAGGACTATTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2843.7) | IGHD3-2200(49),IGHD2-200(45),IGHD5-12*00(44) | IGHJ6*00(511) | nan | 57|351|373|0|294|SC118TST128CSG148ASG153ASA216GST224ASG228ASA231GSC238ASA277GSG300ASA322CSC341T|2563.0 | 16|32|93|302|317|DC20SA27G|49.0;40|49|93|307|316||45.0;27|42|69|304|318|SG34ADC36|44.0 | 29|83|83|337|391|SC33T|511.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTTCTGCAAGGCCTCT | 40 | GGAGGCACCTTCAGCAACTATACT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTGTCTTTGGAACAACA | 40 | GACTACGAACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGGATCCACGAGCACAGCCTACATGAAGCTGAGCAGCCTGAGATCTGCGGACACGGCCGTGTATTAT | 40 | TGTGCGAGATCCTCCCCCTATATAGTAGTACGAAAACCTACTGGGAACCAGGACTATTACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVFCKAS | GGTFSNYT | ISWVRQAPGQGLEWMGG | IIPVFGTT | DYEQKFQGRVTITADGSTSTAYMKLSSLRSADTAVYY | CARSSPYIVVRKPTGNQDYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-2:294:302:15:-30:317:337:-9:360:391:: |
| 74 | 122 | 0.00205163 | CAGGTGCACCTGGTGCAGTCAGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCACGGCTTCTGGATATGACTTCAACATTTATGATATCCACTGGGTGCGACAGTCCACTGGACAGGGGCTTGAGTGGATGGGATGGATGACCCCTAAGCGTGAAACCCCAGGCTATGCACCGAAGTTCCAGGGCAGATTCACCATGACCAGGGACACCTCCAGAAGTGCAGTTTACATGGAGCTGAGCAGCCTGGGATCTGAGGACACGGCCGTGTATTTCTGTGCGCGGGGCGGCCACGGTTTCTGGAGTGGTGAAACGTACTACTACGCCATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-8*00(2540.9) | IGHD3-3*00(57) | IGHJ6*00(492) | nan | 57|354|373|0|297|SG65CST77ASA124CSC137TSA138GSC139ASC145ASG148TSA159CSG174TSA185GSA211CSC218GSA219CSG223AST224ASA226CSA228CSA241CSG258TSA273GST283GSC287TSA288GSC292TSC293TSA315GSA340TSA348CSA350G|2100.0 | 36|53|93|301|318|SA39GST43C|57.0 | 28|83|83|324|379|SG38CST39C|492.0 | nan | CAGGTGCACCTGGTGCAGTCAGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCACGGCTTCT | 40 | GGATATGACTTCAACATTTATGAT | 40 | ATCCACTGGGTGCGACAGTCCACTGGACAGGGGCTTGAGTGGATGGGATGG | 40 | ATGACCCCTAAGCGTGAAACCCCA | 40 | GGCTATGCACCGAAGTTCCAGGGCAGATTCACCATGACCAGGGACACCTCCAGAAGTGCAGTTTACATGGAGCTGAGCAGCCTGGGATCTGAGGACACGGCCGTGTATTTC | 40 | TGTGCGCGGGGCGGCCACGGTTTCTGGAGTGGTGAAACGTACTACTACGCCATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVHLVQSGAEVKKPGASVKVSCTAS | GYDFNIYD | IHWVRQSTGQGLEWMGW | MTPKRETP | GYAPKFQGRFTMTRDTSRSAVYMELSSLGSEDTAVYF | CARGGHGFWSGETYYYAMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:1:297:301:-5:-9:318:324:-8:348:379:: |
| 75 | 122 | 0.00205163 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCACCACCTATGATATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGGGGATCATCCCTTTGTTTGATGCAACAAAGTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAGTCCACGGGCACAGCCTACATGGAATTGAGCAGCCTGAGATCTGAGGACACGGCCATGTATTACTGTGCGAGAGATCGAAGTAGTAGCTGGTACAATGGGACATTCTACTTTGACTCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2783.2) | IGHD2-200(51),IGHD6-1300(47),IGHD6-19*00(47) | IGHJ4*00(441) | nan | 57|355|373|0|298|SA91GSG145CSG148CSC154ASA203GSA216TSC218GSG223ASA225GSG228ASC233GSG276ASA278GSA285GSG302ASC303TSG333A|2487.0 | 4|17|93|302|315|SC7T|51.0;27|42|63|300|315|SC29TSC32T|47.0;27|42|63|300|315|SC29TSG33A|47.0 | 21|68|68|326|373|SA32C|441.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCACCACCTATGAT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGGGGG | 40 | ATCATCCCTTTGTTTGATGCAACA | 40 | AAGTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAGTCCACGGGCACAGCCTACATGGAATTGAGCAGCCTGAGATCTGAGGACACGGCCATGTATTAC | 39 | TGTGCGAGAGATCGAAGTAGTAGCTGGTACAATGGGACATTCTACTTTGACTCCTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVRKPGSSVKVSCKAS | GGTFTTYD | ISWVRQAPGQGLEWMGG | IIPLFDAT | KYAQKFQGRVTITADKSTGTAYMELSSLRSEDTAMYY | CARDRSSSWYNGTFYFDSW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:2:298:302:27:-45:315:326:-1:342:373:: |
| 76 | 115 | 0.00193391 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGACACCTTCACGACTAATAGTCTCAACTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGAGGGATCATCCCTGTGGTTGGTACAACAAAATACGCACAGAAATACCAGGACAGAGTCACCATCACCGGGGACAAATCCACGAACACAGCCTACATGGAACTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTACTGTGCGAGAGGTCTCTTGTACGCTACCACTTACTTTGATTACTGGGGCCAGGGAACCCCGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2478.8) | IGHD2-1500(40),IGHD6-1300(38),IGHD6-19*00(38) | IGHJ4*00(402) | nan | 57|358|373|0|301|SG136ASG145CSC146GSG148CSC149TST150ASG153ASC154GSA156CSG160ASG188ASA216GSC218GST219GSG228ASC233ASG245AST247ASG253ASG263CST266CSC271GSG276ASG286ASG302ASG323CSG335CSA352G|2198.0 | 9|17|93|306|314||40.0;38|48|63|302|313|I43C|38.0;38|48|63|302|313|I43C|38.0 | 22|68|68|315|361|SC30TST50C|402.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGACACCTTCACGACTAATAGT | 40 | CTCAACTGGGTGCGACAGGCCCCTGGACAAGGACTTGAGTGGATGGGAGGG | 40 | ATCATCCCTGTGGTTGGTACAACA | 40 | AAATACGCACAGAAATACCAGGACAGAGTCACCATCACCGGGGACAAATCCACGAACACAGCCTACATGGAACTGAGCAGCCTGAGATCTGACGACACGGCCGTCTATTAC | 40 | TGTGCGAGAGGTCTCTTGTACGCTACCACTTACTTTGATTACTGG | 40 | GGCCAGGGAACCCCGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GDTFTTNS | LNWVRQAPGQGLEWMGG | IIPVVGTT | KYAQKYQDRVTITGDKSTNTAYMELSSLRSDDTAVYY | CARGLLYATTYFDYW | GQGTPVTVSS_ | ::::0:75:99:150:174:285:5:301:306:22:-45:314:315:-2:330:361:: |
| 77 | 115 | 0.00193391 | CAAGTTCACTTGGTGCAGTCTGGAGGTGAACTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGCTTTAGTGACTTCGGTATAACGTGGGTGCGACAGGCCCCTGGACAAGGACTTGAATGGATGGGATGGATCAGCGGTAAAAATGGGAACACAAATTATGCACAGAAGGTCCAGGGCAGAGTCACCTTGACCGCGGACACATCGACGAGCACAGCCTACATGGAGATGAGGGCCCTGACATCTGACGACACGGGCATATATTACTGTGCCCGCAGTGACTACTACGAAGACACTGGCACGTTTGAAAACTGGGGCCAGGGAACCCCGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2175.9) | IGHD1-2600(41),IGHD2-200(40),IGHD4-17*00(40) | IGHJ4*00(343) | nan | 57|347|373|0|290|SG59ASG65CSC66TSC82GSG86ASG87CSC139GSC145GSC146TSA147GSG148ASA151TST152CSC158ASG160CSC161GSG188ASG194ASC214GST216ASC218AST224GSC233TSC246GSA264TSA270GSA272GSC281GSC303ASA309GSG310CSG316CSC331GSG333ASG335A|1885.0 | 33|44|60|299|310|ST41A|41.0;15|23|93|298|306||40.0;24|32|48|295|303||40.0 | 25|68|68|321|364|SC30AST31AST50C|343.0 | nan | CAAGTTCACTTGGTGCAGTCTGGAGGTGAACTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACAGCTTTAGTGACTTCGGT | 40 | ATAACGTGGGTGCGACAGGCCCCTGGACAAGGACTTGAATGGATGGGATGG | 40 | ATCAGCGGTAAAAATGGGAACACA | 40 | AATTATGCACAGAAGGTCCAGGGCAGAGTCACCTTGACCGCGGACACATCGACGAGCACAGCCTACATGGAGATGAGGGCCCTGACATCTGACGACACGGGCATATATTAC | 40 | TGTGCCCGCAGTGACTACTACGAAGACACTGGCACGTTTGAAAACTGG | 40 | GGCCAGGGAACCCCGGTCACCGTCTCCTCAG | 40 | QVHLVQSGGELKKPGASVKVSCKAS | GYSFSDFG | ITWVRQAPGQGLEWMGW | ISGKNGNT | NYAQKVQGRVTLTADTSTSTAYMEMRALTSDDTGIYY | CARSDYYEDTGTFENW | GQGTPVTVSS_ | ::::0:75:99:150:174:285:-6:290:299:-13:4:310:321:-5:333:364:: |
| 78 | 114 | 0.00191709 | CAGGTGCAGGTGGAGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGCTGAAAGTCTCCTGTAAGACCTCTGGAGGCCCCTTCAGCAGCCAAGCTTTCAACTGGGTGCGACAGGCCCGTGGACATGGGCTTGAGTGGATGGGAGGCATCATCCCTCTTCTTGGCTCAACAACCTACGCACAGAAGTTCCAGGACAGAGTCACGTTTACCGCGGACGAATCGACGAGCACAGTCTACATGGAGTTGAGAAGCCTGAGATCTGAGGACACGGCCACCTATTTTTGCGCGATGAGTGATGGTCCTTACTTTTATTACGTTATCGACGTCTGGGGCCGAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2231) | IGHD1-700(40),IGHD3-1600(37),IGHD6-13*00(35) | IGHJ6*00(406) | nan | 57|333|373|0|276|SC66GST70ASG108CSG113ASC122TSG126AST128CSA138CST150CST152ASA156TSG160ASC178GSA185TSG206CSA216CSC218TST219CST224CSA225TSG228ASA232CSG253ASA264TSC281GSC292TSC303TSC308A|1948.0 | 2|10|51|187|195||40.0;58|75|111|199|214|ST62CDT64DA69|37.0;29|36|63|86|93||35.0 | 25|83|83|306|364|SA29TSC30TSC33TSG38TSG42CSA56G|406.0 | nan | CAGGTGCAGGTGGAGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGCTGAAAGTCTCCTGTAAGACCTCT | 40 | GGAGGCCCCTTCAGCAGCCAAGCT | 40 | TTCAACTGGGTGCGACAGGCCCGTGGACATGGGCTTGAGTGGATGGGAGGC | 40 | ATCATCCCTCTTCTTGGCTCAACA | 40 | nan | nan | nan | nan | GGCCGAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQVEQSGAEVKKPGSSLKVSCKTS | GGPFSSQA | FNWVRQARGHGLEWMGG | IIPLLGST | nan | nan | GRGTTVTVSS_ | ::::0:75:99:150:174::::187:15:-24:195:306:-5:333:364:: |
| 79 | 112 | 0.00188346 | CAGCTTCACTTGGTGCAATCTGGGGCTGTTGTGAAGAAGCCTGGGGCCTCAGTGACGGTTTCCTGCTCGGCATCTGGATACCCTGTCACTGCCTACTATATGCACTGGGTGCGACAGGCCCCTGGACGAGGGCTTGAGTGGATGGGAGGGATCAACCCTGCCACTGGCGCCGCAAAGTATACACAGACATTCCAGGGCAGGGTCACCATGACCAGGGACACGTCCACGAGTACAGTCTTCATGGAACTGAGCGGCCTGACATCTGAGGACACGGCCGTCTTTTACTGTGCGAGAGGGGGGGGGTTGGAGTGGCTGGATCTGCTGCTTTTGATATGTGGGGCCAAGGGACCTTGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-46*00(2266.3) | IGHD3-300(45),IGHD6-1900(45) | IGHJ3*00(384) | nan | 57|352|373|0|295|SG60CSG62TSG65CSC66TSG74ASA85TSG86TSA112CSA123TSA124CSA138CSC140TST141GSC146TSA147GSG148CSA184GSA204GST205GSA206GSA216GSG217CST218CSG219ASG220CST224CSA225GSG226CSA228GSG232ASC233GSC236TSG237ASA244CSG245ASA257GSC287TSA295TSG302ASA309GSG316CSG335CSA337T|1703.0 | 43|52|93|303|312||45.0;30|39|63|307|316||45.0 | 20|70|70|319|369|SA22CSC35GSA50CSA51T|384.0 | nan | CAGCTTCACTTGGTGCAATCTGGGGCTGTTGTGAAGAAGCCTGGGGCCTCAGTGACGGTTTCCTGCTCGGCATCT | 40 | GGATACCCTGTCACTGCCTACTAT | 40 | ATGCACTGGGTGCGACAGGCCCCTGGACGAGGGCTTGAGTGGATGGGAGGG | 40 | ATCAACCCTGCCACTGGCGCCGCA | 40 | AAGTATACACAGACATTCCAGGGCAGGGTCACCATGACCAGGGACACGTCCACGAGTACAGTCTTCATGGAACTGAGCGGCCTGACATCTGAGGACACGGCCGTCTTTTAC | 39 | TGTGCGAGAGGGGGGGGGTTGGAGTGGCTGGATCTGCTGCTTTTGATATGTGG | 40 | GGCCAAGGGACCTTGGTCACCGTCTCTTCAG | 40 | QLHLVQSGAVVKKPGASVTVSCSAS | GYPVTAYY | MHWVRQAPGRGLEWMGG | INPATGAA | KYTQTFQGRVTMTRDTSTSTVFMELSGLTSEDTAVFY | CARGGGLEW_GSAAFDMW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:303:-12:-10:312:319:0:338:369:: |
| 80 | 112 | 0.00188346 | CAGGTGCAACTTGTCCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAACATTTCCTGCAGGGCTTCTGGATTCACCTTCAGTGACCATCTTATAAATTGGGTGCGCCAAGTCCCCGGACAAAGCCTTGAGTGGATGGGTTGGATTAACCCTGACAATGGAAACACAAAATATTCACAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGTCTACGTGGAAGTGAGCGACCTGACATCTGAAGACACGGCTGTCTTTTACTGTGCGAGAGACATACTGTCCGTCGGCCCGCGCGCGAATGATGCTTTTGATGTCTGGGGCCAAGGGACCATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(2076.5) | IGHD4-1100(30),IGHD4-400(30),IGHD5-5*00(28) | IGHJ3*00(452) | nan | 57|353|373|0|296|SC62GSG65ASG71CSA91GSG113CSG114ASA124GSA136TSC145GSA147GSG148AST150CSG153CSC154TSG158ASC159ASG173ASC175TSG188CSA203TSC209TSG213CSG217AST224ASA244CSA267TSG273CSA276TSC289TSC292TSA297GSG302ASC303GSA309GSG310ASG316CSG335CSA337T|1858.0 | 5|11|48|298|304||30.0;5|11|48|298|304||30.0;5|14|60|296|304|DG9|28.0 | 19|70|70|322|373|SA33GSA50C|452.0 | nan | CAGGTGCAACTTGTCCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAACATTTCCTGCAGGGCTTCT | 40 | GGATTCACCTTCAGTGACCATCTT | 40 | ATAAATTGGGTGCGCCAAGTCCCCGGACAAAGCCTTGAGTGGATGGGTTGG | 40 | ATTAACCCTGACAATGGAAACACA | 40 | AAATATTCACAGACGTTCCAGGGCAGAGTCACCATTTCCAGGCACTCATCCGCGAGCATAGTCTACGTGGAAGTGAGCGACCTGACATCTGAAGACACGGCTGTCTTTTAC | 39 | TGTGCGAGAGACATACTGTCCGTCGGCCCGCGCGCGAATGATGCTTTTGATGTCTGG | 40 | GGCCAAGGGACCATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVRKPGASVNISCRAS | GFTFSDHL | INWVRQVPGQSLEWMGW | INPDNGNT | KYSQTFQGRVTISRHSSASIVYVEVSDLTSEDTAVFY | CARDILSVGPRANDAFDVW | GQGTMVTVSS_ | ::::0:75:99:150:174:285:0:296:298:11:-21:304:322:1:342:373:: |
| 81 | 111 | 0.00186664 | CAGGTTCAGTTGGTGCAGTCTGGAGCTGAGATGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCACCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACTCACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACGTGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTCTATTACTGTGCGAGAGAGCATTTTCCCTCCACCTACGACAGCTTCGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2947.2) | IGHD5-1200(30),IGHD5-1800(30),IGHD2-15*00(29) | IGHJ4*00(411) | nan | 57|353|373|0|296|SC66TSG87ASG148CST152CSA230TSA231CSA297GSG335C|2728.0 | 36|42|69|311|317||30.0;36|42|69|311|317||30.0;13|24|93|307|319|I18TST20G|29.0 | 24|68|68|320|364|ST27C|411.0 | nan | CAGGTTCAGTTGGTGCAGTCTGGAGCTGAGATGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACCTTTACCACCTACGGT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCGCTTACAATGGTAACACT | 40 | CACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACGTGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTCTATTAC | 39 | TGTGCGAGAGAGCATTTTCCCTCCACCTACGACAGCTTCGACTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEMKKPGASVKVSCKAS | GYTFTTYG | ISWVRQAPGQGLEWMGW | ISAYNGNT | HYAQKLQGRVTMTTDTSTSTAYVELRSLRSDDTAVYY | CAREHFPSTYDSFDYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285:0:296:311:-13:-4:317:320:-4:333:364:: |
| 82 | 110 | 0.00184983 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCACCTATGCTATCACCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGCTGGGAGGGATCATCCCTATCTTTGGTACAACAGACTACGCACGGAAGTTCCAGGGCAGAGTCACGATTACCGCGGCCGAATCCACGAGCACAGTCTTCATTGAACTGAGCAGCCTGACATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGAGTGGGAGCTTACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2901.9) | IGHD1-26*00(50) | IGHJ4*00(490) | nan | 57|352|373|0|295|SG148CSG160CSA198CSG228ASA231GSA241GSA274CSC292TSA295TSG299TSG302ASG316C|2602.0 | 25|35|60|296|306||50.0 | 19|68|68|306|355||490.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCACCTATGCT | 40 | ATCACCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGCTGGGAGGG | 40 | ATCATCCCTATCTTTGGTACAACA | 40 | GACTACGCACGGAAGTTCCAGGGCAGAGTCACGATTACCGCGGCCGAATCCACGAGCACAGTCTTCATTGAACTGAGCAGCCTGACATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGAGGAGTGGGAGCTTACTACTTTGACTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSTYA | ITWVRQAPGQGLEWLGG | IIPIFGTT | DYARKFQGRVTITAAESTSTVFIELSSLTSEDTAVYY | CARGVGAYYFDYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:296:-5:-5:306:306:1:324:355:: |
| 83 | 110 | 0.00184983 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGCGCTAGTGGGAGCCTCCCTCGTCGGGGGTCGCTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(3227.3) | IGHD1-26*00(50) | IGHJ6*00(530) | nan | 57|352|373|0|295||2950.0 | 24|34|60|298|308||50.0 | 30|83|83|326|379||530.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCAGCTATGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATCTTTGGTACAGCA | 40 | AACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 39 | TGTGCGAGAGCGCTAGTGGGAGCCTCCCTCGTCGGGGGTCGCTACTACGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFSSYA | ISWVRQAPGQGLEWMGG | IIPIFGTA | NYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYY | CARALVGASLVGGRYYGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285295:298:-4:-6:308:326:-10:348:379:: |
| 84 | 110 | 0.00184983 | CAGGTACAGTTGGTGCAGTCTGGGCCTCAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCACGGCTTCTGGAGGCACCTTCGGCAGGTATACTATCTCCTGGGTGCGACAGGCCCCTGGGCAGGGGCTTGAGTGGATGGGAGGGATCCTCCCTGTCCTTGGGAACACAAACGTCGCACAGAGATTCCAGGATAGACTCACATTTACCGCGGACGAATCCACGAGCACAGCCTACTTGGAACTGAGCAGCCTGAGACCTGAGGACACGGCCGTCTATTACTGTGCGCGAGGGTCCGTTGTTCTGACTGGGACAAACGCCCCCTTTGCCCACTGGGGCCAGGGAATCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2326.5) | IGHD3-900(36),IGHD7-2700(31) | IGHJ4*00(353) | nan | 57|352|373|0|295|SG62ASC66TSG81CSG84CSA124CSA144GSC149GSG153ASA159TSG160CSA182GSA185GSA210CSA216GST219CST224GSC226ASA227CSG228AST234GSA235TSA244GSG245ASG253ASC254TSG258CSG263ASA264TSA297TSG302AST318CSG335CSA348C|1993.0 | 42|52|93|304|314|ST44C|36.0;11|20|33|306|315|SA13G|31.0 | 24|68|68|326|370|SA29CST31CSC47T|353.0 | nan | CAGGTACAGTTGGTGCAGTCTGGGCCTCAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCACGGCTTCT | 40 | GGAGGCACCTTCGGCAGGTATACT | 40 | ATCTCCTGGGTGCGACAGGCCCCTGGGCAGGGGCTTGAGTGGATGGGAGGG | 40 | ATCCTCCCTGTCCTTGGGAACACA | 40 | AACGTCGCACAGAGATTCCAGGATAGACTCACATTTACCGCGGACGAATCCACGAGCACAGCCTACTTGGAACTGAGCAGCCTGAGACCTGAGGACACGGCCGTCTATTAC | 40 | TGTGCGCGAGGGTCCGTTGTTCTGACTGGGACAAACGCCCCCTTTGCCCACTGG | 40 | GGCCAGGGAATCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGPQVKKPGSSVKVSCTAS | GGTFGRYT | ISWVRQAPGQGLEWMGG | ILPVLGNT | NVAQRFQDRLTFTADESTSTAYLELSSLRPEDTAVYY | CARGSVVLTGTNAPFAHW | GQGILVTVSS_ | ::::0:75:99:150:174:285295:304:-11:-10:314:326:-4:339:370:: |
| 85 | 110 | 0.00184983 | GAGGTGCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCTGGATTCTCCTTTAGTTCCTATGCCATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTAGTGCTAGAGGCGGGAGTTCATACTTCGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAGCCTGAGAGCCGAGGACACGGCCACATATTTCTGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCACTGGGGCCAGGGAACCCTGGTCCTCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV3-23*00(2340.5) | IGHD5-18*00(51) | IGHJ4*00(333) | nan | 57|352|373|0|295|ST69CSG74AST117GSA138TSC146TSA147TSG148CSA159GSG160TSC205TSG214CST218AST221CST224GSC227TSA228TSA235TSC287TSA288GSC289TSA295CSC300GSG333AST334CSA340T|2225.0 | 25|38|69|303|316|SG35C|51.0 | 26|68|68|319|361|ST31CSA55CSC56T|333.0 | nan | GAGGTGCAGCTGCTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCGCCTGTGCAGCCTCT | 40 | GGATTCTCCTTTAGTTCCTATGCC | 40 | ATGGTCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTT | 40 | ATTAGTGCTAGAGGCGGGAGTTCA | 40 | TACTTCGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAATGTGCTGTCTCTGGAAATGAACAGCCTGAGAGCCGAGGACACGGCCACATATTTC | 39 | TGTGCGAAAGGTTCTATCGAATATAGTGCCTCGGTTGACCACTGG | 40 | GGCCAGGGAACCCTGGTCCTCGTCTCCTCAG | 40 | EVQLLESGGGLVQPGGSLRLACAAS | GFSFSSYA | MVWVRQAPGKGLEWVSV | ISARGGSS | YFADSVKGRFTISRDNSKNVLSLEMNSLRAEDTATYF | CAKGSIEYSASVDHW | GQGTLVLVSS_ | ::::0:75:99:150:174:285295:303:-2:-8:316:319:-6:330:361:: |
| 86 | 108 | 0.00181619 | CAGGTTCTACTGGTGCAGTCCGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCCTCGGGTTACTCTTTCAGCACCTACGGTGTCAGCTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGATGGCTCAACACTGGAGACGGTAACACAGCCTATGCACAGAAGCTCCAGGGCAGAATCACCTTGACCACAGACACATCCACGACAACAGCCTACATGGAACTGAGGAGCCTGAGATCTGACGACACGGCCATTTATTACTGTGCGAGAGGGGAGAACTATGGGTCGGCGAGGGACGTCTTTGACCACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2351.8) | IGHD3-10*00(38) | IGHJ4*00(411) | nan | 57|352|373|0|295|SA64TSG65AST77CST128CST131GSA138TSC140TST143CSC145GSG148CST152CSA156GST179ASA207CSG211ASG213AST216GSA217GSC218ASA219GST221CSA231GSA232CSG258ASA264TSG286CSC287ASG302ASG333ASG335T|2080.0 | 36|52|93|301|317|ST43GSA46GSG48C|38.0 | 24|68|68|323|367|ST31C|411.0 | nan | CAGGTTCTACTGGTGCAGTCCGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCCTCG | 40 | GGTTACTCTTTCAGCACCTACGGT | 40 | GTCAGCTGGGTGCGACAGGCCCCAGGACAAGGGCTTGAGTGGATGGGATGG | 40 | CTCAACACTGGAGACGGTAACACA | 40 | GCCTATGCACAGAAGCTCCAGGGCAGAATCACCTTGACCACAGACACATCCACGACAACAGCCTACATGGAACTGAGGAGCCTGAGATCTGACGACACGGCCATTTATTAC | 40 | TGTGCGAGAGGGGAGAACTATGGGTCGGCGAGGGACGTCTTTGACCACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVLLVQSGAEVKKPGASVKVSCKAS | GYSFSTYG | VSWVRQAPGQGLEWMGW | LNTGDGNT | AYAQKLQGRITLTTDTSTTTAYMELRSLRSDDTAIYY | CARGENYGSARDVFDHW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:301:-5:-10:317:323:-4:336:367:: |
| 87 | 108 | 0.00181619 | CAGGTGCAGCTGGTGCAGTCTGGTGTTGAGGTGAAGAAGCCTGGGTCCTCGGTGAGGGTCTCCTGCAAGGCTTCTGGAGACACCTTCAAGAACTCTGTTATTAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGACCATCCCTCTCTTTGGGACAACTGACTATGCCCAGAAGTTCCAGGGCAGACTCACAATTACGACGGACGAGTCTACGACTACAGCCTACATGGAAGTGAGTAGACTGACATCTGAGGACACGGCCGTTTATTACTGTGTGGCGGAACTGGACTTCGGGAAATTATCTGTCGTCTGGGGCCAGGGGACCACGGTCATCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2233.7) | IGHD1-100(35),IGHD1-2000(35),IGHD1-7*00(35) | IGHJ6*00(293) | nan | 57|346|373|0|289|SG80TSC82TSA112GSG136ASG145ASC146GSG148ASA151CSC154TSC158TST208CSA216CST224GSG228ASA230TSA231GSC236TSA239CSG258CSG263ASC269GSG270ASA278GSC281TSG286CSC287TSG302ASC303GSC308TSC311ASG316CSG335T|1962.0 | 22|29|51|295|302||35.0;22|29|51|295|302||35.0;22|29|51|295|302||35.0 | 45|83|83|320|358|SA57GSC71TSC78T|293.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGTGTTGAGGTGAAGAAGCCTGGGTCCTCGGTGAGGGTCTCCTGCAAGGCTTCT | 40 | GGAGACACCTTCAAGAACTCTGTT | 40 | ATTAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ACCATCCCTCTCTTTGGGACAACT | 40 | GACTATGCCCAGAAGTTCCAGGGCAGACTCACAATTACGACGGACGAGTCTACGACTACAGCCTACATGGAAGTGAGTAGACTGACATCTGAGGACACGGCCGTTTATTAC | 40 | TGTGTGGCGGAACTGGACTTCGGGAAATTATCTGTCGTCTGG | 40 | GGCCAGGGGACCACGGTCATCGTCTCTTCAG | 40 | QVQLVQSGVEVKKPGSSVRVSCKAS | GDTFKNSV | ISWVRQAPGQGLEWMGG | TIPLFGTT | DYAQKFQGRLTITTDESTTTAYMEVSRLTSEDTAVYY | CVAELDFGKLSVVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285:-7:289:295:-5:-5:302:320:-25:327:358:: |
| 88 | 108 | 0.00181619 | CAGGTGCAGCTGGTGCAATCTGGGGCTGAGGTGAAGCAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCCTCTAGAGGCGCCCTCAGCAGCTATGCTATCACGTGGGTGCGACAGGCCCCTGGACAAGGGCTTGACTGGATGGGAAGGGTCATCCCTATCTATGGAACACCAAACTACGCGCAGAAGTTCCAGGGCAGACTCTCGCTTACCGTGGACGCATCCAAGAGCACAGCTTACTTGGAGCTGAGCGGCCTGAGATCTGAGGACACGGCCGTTTATTTCTGTGCGAGCGCGGGATCGCGAGAGATCAACCGCGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2453.6) | IGHD5-2400(30),IGHD7-2700(30) | IGHJ3*00(470) | nan | 57|350|373|0|293|SG74ASA93CST128CSG132ASA138GST141CSG160CSC161GSG194CSG204ASA207GST220AST224ASG228CSA239GSG258CSA261TSA264CSC271TSA277CSC283ASC293TSA297TSA309GSG335TSA340T|2176.0 | 22|28|60|305|311||30.0;18|24|33|296|302||30.0 | 23|70|70|320|367||470.0 | nan | CAGGTGCAGCTGGTGCAATCTGGGGCTGAGGTGAAGCAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCCTCT | 40 | AGAGGCGCCCTCAGCAGCTATGCT | 40 | ATCACGTGGGTGCGACAGGCCCCTGGACAAGGGCTTGACTGGATGGGAAGG | 40 | GTCATCCCTATCTATGGAACACCA | 40 | AACTACGCGCAGAAGTTCCAGGGCAGACTCTCGCTTACCGTGGACGCATCCAAGAGCACAGCTTACTTGGAGCTGAGCGGCCTGAGATCTGAGGACACGGCCGTTTATTTC | 40 | TGTGCGAGCGCGGGATCGCGAGAGATCAACCGCGGTGCTTTTGATATCTGG | 40 | GGCCAAGGGACAATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGAEVKQPGSSVKVSCKAS | RGALSSYA | ITWVRQAPGQGLDWMGR | VIPIYGTP | NYAQKFQGRLSLTVDASKSTAYLELSGLRSEDTAVYF | CASAGSREINRGAFDIW | GQGTMVTVSS_ | ::::0:75:99:150:174:285:-3:293:305:-2:-12:311:320:-3:336:367:: |
| 89 | 107 | 0.00179938 | CAGGTGCAGTTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCCTCACAACCTTTTTTATGCACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGTAATCAATCCTGGATATCCCGCTGGTAGAAGCACTACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACTGACACGTCCACGAGCACAGTATACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGGGAGGCCATTGTAGCGGGAGCTACAACCGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCGTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-46*00(2708.3) | IGHD1-26*00(52) | IGHJ6*00(441) | nan | 57|353|373|0|305|SC66TSG86AST141CSC146ASG148CSA151TSC152TSA154TSG188CSA204GSC212TSA216GI218AI218TI218AI218TI218CI218CI218CI218GI218CSG222AST224ASA230TSG232CSG271CSG272TSC293ASC311GSG323CSA350G|2172.0 | 24|40|60|313|329|ST27CST37A|52.0 | 36|83|83|329|376|SC78G|441.0 | nan | CAGGTGCAGTTGGTGCAGTCTGGGGCTGAAGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCT | 40 | GGATACACCCTCACAACCTTTTTT | 40 | ATGCACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGTA | 40 | ATCAATCCTGGATATCCCGCTGGTAGAAGCACT | 40 | ACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCACTGACACGTCCACGAGCACAGTATACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTAC | 40 | TGTGCGAGGGAGGCCATTGTAGCGGGAGCTACAACCGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCGTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCKAS | GYTLTTFF | MHWVRQAPGQGLEWMGV | INPGYPAGRST | TYAQKFQGRVTMTTDTSTSTVYMELSRLRSDDTAVYY | CAREAIVAGATTGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:183:294:0:305:313:-4:0:329:329:-16:345:376:: |
| 90 | 105 | 0.00176574 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCACCAACTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATGTTTGGAACAACAAACCACGCACAGAAGTTCCAGGGCAGAGTCACGATTAACGCGAACAAATCCACGACCACAGCCCACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGATAGGCATTGGGTTACGATATTTTGACTGGCCATTTGAGTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2851.8) | IGHD3-9*00(90) | IGHJ4*00(401) | nan | 57|352|373|0|295|SG145CSG148ASG153ASC218GST224ASG228AST234CSC268ASG273ASG276ASG286CST294CSG349T|2573.0 | 34|52|93|303|321||90.0 | 25|68|68|324|367|SC30G|401.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCACCAACTATACT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATGTTTGGAACAACA | 40 | AACCACGCACAGAAGTTCCAGGGCAGAGTCACGATTAACGCGAACAAATCCACGACCACAGCCCACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGATAGGCATTGGGTTACGATATTTTGACTGGCCATTTGAGTACTGG | 40 | GGCCAGGGAACCCTGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGSSVKVSCKAS | GGTFTNYT | ISWVRQAPGQGLEWMGG | IIPMFGTT | NHAQKFQGRVTINANKSTTTAHMELSSLRSEDTAVYY | CAIGIGLRYFDWPFEYW | GQGTLVTVSS_ | ::::0:75:99:150:174:285295:303:-3:-10:321:324:-5:336:367:: |
| 91 | 105 | 0.00176574 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTTAAGGTCTCCTGCACGGCTTCTGGATACACCTTCATCGACTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGGTGGATCAACCCTAGCAGTGGTGGCACACACTATGCACAGAAGTTTCAGGGCAGGGTCGCCATGACCAGGGACACGTCCATCAGCATAGTCTACATGGAGCTGAGCAGGCTGAAGTCTGACGACACGGCCATGTATTATTGTGCGAGAGATCGGGGATATGATTGTCCTGCCTCCTACTGCTACGCGTTATCCGGTCTGGACGTCTGGGGCCAAGGGACCAGGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-2*00(2834.3) | IGHD2-1500(35),IGHD3-1600(35),IGHD6-19*00(35) | IGHJ6*00(412) | nan | 57|355|373|0|298|SG110TSA124CSC145TSG148ASG188CSA203GSA217GSA231CST255ASA261GSC289TSC292TSG316ASA317GSG333ASC341T|2516.0 | 52|59|93|323|330||35.0;41|48|111|303|310||35.0;9|16|63|322|329||35.0 | 36|83|83|338|385|SA40CSC65G|412.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTTAAGGTCTCCTGCACGGCTTCT | 40 | GGATACACCTTCATCGACTACTAT | 40 | ATGCACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGGTGG | 40 | ATCAACCCTAGCAGTGGTGGCACA | 40 | CACTATGCACAGAAGTTTCAGGGCAGGGTCGCCATGACCAGGGACACGTCCATCAGCATAGTCTACATGGAGCTGAGCAGGCTGAAGTCTGACGACACGGCCATGTATTAT | 40 | TGTGCGAGAGATCGGGGATATGATTGTCCTGCCTCCTACTGCTACGCGTTATCCGGTCTGGACGTCTGG | 40 | GGCCAAGGGACCAGGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGASVKVSCTAS | GYTFIDYY | MHWVRQAPGQGLEWMGW | INPSSGGT | HYAQKFQGRVAMTRDTSISIVYMELSRLKSDDTAMYY | CARDRGYDCPASYCYALSGLDVW | GQGTRVTVSS_ | ::::0:75:99:150:174:285:2:298:323:-21:-3:330:338:-16:354:385:: |
| 92 | 104 | 0.00174893 | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCGGGGTACTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCACCTATGGTATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGATACAACAAACTACGCACAGAAGTTCCAGGGCAAATTCACGATTACCGCGGACGAATCCACGAGCACAGTCTACATGGAGCTCAGTAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGATGAGGCAGCAGCTGCCACGAGCGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2884.4) | IGHD6-1300(50),IGHD2-1500(46) | IGHJ6*00(470) | nan | 57|354|373|0|297|ST98GSC103ASG148CSC154GSG160ASG223ASG228ASG256ASG258TSC292TSG305CSC308T|2622.0 | 28|38|63|300|310||50.0;5|17|93|302|314|SA12G|46.0 | 36|83|83|317|364||470.0 | nan | CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCGGGGTACTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCACCTTCAGCACCTATGGT | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGG | 40 | ATCATCCCTATCTTTGATACAACA | 40 | AACTACGCACAGAAGTTCCAGGGCAAATTCACGATTACCGCGGACGAATCCACGAGCACAGTCTACATGGAGCTCAGTAGCCTGAGATCTGAGGACACGGCCGTGTATTAC | 40 | TGTGCGAGAGATGAGGCAGCAGCTGCCACGAGCGGTATGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVQLVQSGAEVKKPGYSVKVSCKAS | GGTFSTYG | INWVRQAPGQGLEWMGG | IIPIFDTT | NYAQKFQGKFTITADESTSTVYMELSSLRSEDTAVYY | CARDEAAAATSGMDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:1:297:300:-7:-4:310:317:-16:333:364:: |
| 93 | 103 | 0.00173211 | CAGGTTCAGTTGGTGCAGTCTGGAACCGAGGTGAAGACGCCTGGGGCCTCAGTGAAGGTCTCCTGCCACGCCTCTGGTTACACCTTTACCAACTACGGTATCAACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGCATGGATCAGCGCATACAATGGAAAGACACATCACGCACCGTTTGTCCAGGACAGAGTCACCATGACCACAGACACGTCGACGAGGACGGCCTACATGGAACTGACGAGCCTGAGATCTGACGACACGGCCGTCTATTACTGTGCGAGAGGAGGGTGGAACTACGGCCCTGGTCCTTTTGATTTGTGGGGCCAGGGGACAATGGTCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2310) | IGHD1-7*00(50) | IGHJ3*00(363) | nan | 57|352|373|0|295|SC66TSG81AST83CSA94CSA123CSG125CST128CSG148AST152CSG160ASG188CSG202CST215AST224ASC227GSA231CSC233TST234CST236CSA241CSA243TSA244TSG245TSC246GSG253ASA278GSC281GSC287GSA290GSG302ASG307CSG335C|2022.0 | 25|35|51|300|310||50.0 | 25|70|70|319|364|SA33TSC35GSA44G|363.0 | nan | CAGGTTCAGTTGGTGCAGTCTGGAACCGAGGTGAAGACGCCTGGGGCCTCAGTGAAGGTCTCCTGCCACGCCTCT | 40 | GGTTACACCTTTACCAACTACGGT | 40 | ATCAACTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGCATGG | 40 | ATCAGCGCATACAATGGAAAGACA | 40 | CATCACGCACCGTTTGTCCAGGACAGAGTCACCATGACCACAGACACGTCGACGAGGACGGCCTACATGGAACTGACGAGCCTGAGATCTGACGACACGGCCGTCTATTAC | 39 | TGTGCGAGAGGAGGGTGGAACTACGGCCCTGGTCCTTTTGATTTGTGG | 40 | GGCCAGGGGACAATGGTCACCGTCTCTTCAG | 40 | QVQLVQSGTEVKTPGASVKVSCHAS | GYTFTNYG | INWVRQAPGQGLEWMAW | ISAYNGKT | HHAPFVQDRVTMTTDTSTRTAYMELTSLRSDDTAVYY | CARGGWNYGPGPFDLW | GQGTMVTVSS_ | ::::0:75:99:150:174:285295:300:-8:1:310:319:-5:333:364:: |
| 94 | 103 | 0.00173211 | CAGGTCCAGCTTGTCCAGTCTGGGGCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAACATCTCCTGCCAGGCTTCTGGATTCACCTTCAGTGACACTCTTATAAATTGGGTGCGCCAAGGCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACCCTGCCAATGGAAACACAAGATATTCAGAGTCGTTCCAGGGCAGAGTCACCATTTCCAGTCTCTCATCCGCGTCCACAGCCTACGTGGCGCTGAGCGACCTGACATCTGAGGACACGGCTGTTTATTACTGCGCGAGAGACATAGTGAGTGTCGGCCCGCGTGCGAATGATGCTTTTGATGTGTGGGGCCAAGGGACAATGATCACCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-3*00(1972.1) | IGHD3-2200(33),IGHD3-1000(30),IGHD5-12*00(30) | IGHJ3*00(423) | nan | 57|353|373|0|296|SG71CSG87TSG113CSG114AST116CSA123CSA136TSC145GSA147GSG148AST150ASA151CSG153CSC154TSG158ASC159ASG173ASC175GSG213CSG217CST224ASA232GSC240GSA243TSA244CSA267TSG272TSG273CSA274TSA276TSA285TSG286CSA297GSA301CSA309GSG310ASG316CSA323GSG335TST344C|1800.0 | 42|51|93|297|307|I47G|33.0;20|26|93|296|302||30.0;29|35|69|297|303||30.0 | 19|70|70|322|373|SA33GSC35GSG54A|423.0 | nan | CAGGTCCAGCTTGTCCAGTCTGGGGCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAACATCTCCTGCCAGGCTTCT | 40 | GGATTCACCTTCAGTGACACTCTT | 40 | ATAAATTGGGTGCGCCAAGGCCCCGGACAAAGGCTTGAGTGGATGGGATGG | 40 | ATCAACCCTGCCAATGGAAACACA | 40 | AGATATTCAGAGTCGTTCCAGGGCAGAGTCACCATTTCCAGTCTCTCATCCGCGTCCACAGCCTACGTGGCGCTGAGCGACCTGACATCTGAGGACACGGCTGTTTATTAC | 39 | TGCGCGAGAGACATAGTGAGTGTCGGCCCGCGTGCGAATGATGCTTTTGATGTGTGG | 40 | GGCCAAGGGACAATGATCACCGTCTCTTCAG | 40 | QVQLVQSGAELKKPGASVNISCQAS | GFTFSDTL | INWVRQGPGQRLEWMGW | INPANGNT | RYSESFQGRVTISSLSSASTAYVALSDLTSEDTAVYY | CARDIVSVGPRANDAFDVW | GQGTMITVSS_ | ::::0:75:99:150:174:285:0:296:297:-11:-11:307:322:1:342:373:: |
| 95 | 102 | 0.00171529 | CAGGTGGAACTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCAACTTCATCACCTTTGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGAGATCATCCCTATCAGCAGTACAACAAAGTCCGCACATAAATTTCAGGACAGAGTCACGATTTCCGCGGACGGATCTTCGAGCACAGTCCACATGGAGCTGCGCAGCCTGAAATCCGAAGACACGGCCATTTATTTCTGTGCGAAAAAACTGGGGATCGACCCATTTGGGTCCTACGGTCTGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2288.7) | IGHD7-27*00(55) | IGHJ6*00(471) | nan | 57|349|373|0|292|SC63GSG65ASC139ASG145TSG148CSA151TSG188CSG205AST219AST220GST221CSG222ASG228ASC233GSA235CSG242TSG245ASC248TSG253ASA267TSA277GSC281TSA282TSC292TST294CSA306CSG316AST320CSG323ASG333ASG335TSA340T|1992.0 | 13|24|33|295|306||55.0 | 33|83|83|320|370|SA40C|471.0 | nan | CAGGTGGAACTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGAGGCAACTTCATCACCTTTGCT | 40 | ATCAGCTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAGAG | 40 | ATCATCCCTATCAGCAGTACAACA | 40 | AAGTCCGCACATAAATTTCAGGACAGAGTCACGATTTCCGCGGACGGATCTTCGAGCACAGTCCACATGGAGCTGCGCAGCCTGAAATCCGAAGACACGGCCATTTATTTC | 40 | TGTGCGAAAAAACTGGGGATCGACCCATTTGGGTCCTACGGTCTGGACGTCTGG | 40 | GGCCAAGGGACCACGGTCACCGTCTCCTCAG | 40 | QVELVQSGAEVKKPGSSVKVSCKAS | GGNFITFA | ISWVRQAPGQGLEWMGE | IIPISSTT | KSAHKFQDRVTISADGSSSTVHMELRSLKSEDTAIYF | CAKKLGIDPFGSYGLDVW | GQGTTVTVSS_ | ::::0:75:99:150:174:285:-4:292:295:-2:2:306:320:-13:339:370:: |
| 96 | 100 | 0.00168166 | CGGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCCTCTGGAGGCGACTTCAAAAACTTTATTATCGCCTGGGTGCGACAGGCCCCTGGACATGGGCTAGAGTGGATGGGAGGGGTCATCCCAATCTTTGGTACACCAAACTTCGTACAGAAGTTCCAGGACAGAGTCACGATCACCGCGGACGAAGCCACGAGTACCACCTACATGGAGCTGCGCAGCCTGAGATCTGAAGACACGGCCGTCTATTACTGTGCGAGAGTGGGGTCTTGTCTTAGTTCCAGCTGTCTCTACTACGGTATGGATGTCTGGGGCCAAGGGACCACGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-69D*00(2337.1) | IGHD2-200(48),IGHD1-700(45),IGHD1-1*00(41) | IGHJ6*00(472) | nan | 57|352|373|0|295|SA58GSA91GST128CSA138GSC139ASG145ASC146ASG148ASA151TSG153ASC154TSA159GSG160CSA185TST191ASA207GST215ASG228CSA235TSC238TSG253AST266CST279GSC287TSA290CSG291ASA306CSG323ASG335C|2109.0 | 37|55|93|302|320|SA41CSG42TSA47T|48.0;1|10|51|308|317||45.0;3|14|51|310|321|ST10C|41.0 | 30|83|83|323|376|SC45TSC71T|472.0 | nan | CGGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAGGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCCTCT | 40 | GGAGGCGACTTCAAAAACTTTATT | 40 | ATCGCCTGGGTGCGACAGGCCCCTGGACATGGGCTAGAGTGGATGGGAGGG | 40 | GTCATCCCAATCTTTGGTACACCA | 40 | AACTTCGTACAGAAGTTCCAGGACAGAGTCACGATCACCGCGGACGAAGCCACGAGTACCACCTACATGGAGCTGCGCAGCCTGAGATCTGAAGACACGGCCGTCTATTAC | 40 | TGTGCGAGAGTGGGGTCTTGTCTTAGTTCCAGCTGTCTCTACTACGGTATGGATGTCTGG | 40 | GGCCAAGGGACCACGGTCATCGTCTCCTCAG | 40 | RVQLVQSGAEVRKPGSSVKVSCKAS | GGDFKNFI | IAWVRQAPGHGLEWMGG | VIPIFGTP | NFVQKFQDRVTITADEATSTTYMELRSLRSEDTAVYY | CARVGSCLSSSCLYYGMDVW | GQGTTVIVSS_ | ::::0:75:99:150:174:285295:302:-6:-7:320:323:-10:345:376:: |
| 97 | 100 | 0.00168166 | CAGGTTCAGCTGGTGCAGTCTGGAGTAGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTCCCAACTACGGTATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAGACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACCACAGCCTACATGGAGGTAACGAACCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACGTTATCCCCTATTGTGGAAGTGACTGCTACCCGGGGTACTTCCACCACTGGGGCCAGGGCACCCTGGTCATCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-18*00(2799.5) | IGHD2-21*00(58) | IGHJ1*00(402) | nan | 57|353|373|0|296|SC82TST83ASA144CSG148AST152CSG160ASC161TSA231GSG286CSC303GSG305ASG307CSG310A|2583.0 | 32|52|84|306|326|ST40ASG41AST46C|58.0 | 26|72|72|333|379|SG34CSC60T|402.0 | nan | CAGGTTCAGCTGGTGCAGTCTGGAGTAGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCT | 40 | GGTTACACCTTTCCCAACTACGGT | 40 | ATCAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGG | 40 | ATCAGCGCTTACAATGGTAACACA | 40 | GACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGACCACAGCCTACATGGAGGTAACGAACCTGAGATCTGACGACACGGCCGTGTATTAC | 39 | TGTGCGAGAGACGTTATCCCCTATTGTGGAAGTGACTGCTACCCGGGGTACTTCCACCACTGG | 40 | GGCCAGGGCACCCTGGTCATCGTCTCCTCAG | 40 | QVQLVQSGVEVKKPGASVKVSCKAS | GYTFPNYG | INWVRQAPGQGLEWMGW | ISAYNGNT | DYAQKLQGRVTMTTDTSTTTAYMEVTNLRSDDTAVYY | CARDVIPYCGSDCYPGYFHHW | GQGTLVIVSS_ | ::::0:75:99:150:174:285:0:296:306:-4:-4:326:333:-6:348:379:: |
| 98 | 99 | 0.00166484 | CAGGTGCACCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCATGGCTTCTGGATACAACTTCATCGCCCAGAATATACACTGGGTGCGACAGGCCCCTGGACTAGGCCTTGAGTGGATGGGAAAGATGAACCCTAACAGTGGTGGCTCCGACTATGCACAGGAGTTTCAGGGCAGGGTCACCGTGACCAGAGACACGTCCATCTCTACAGTCTACATGGAGTTGACCAGCCTAAAATCTGACGACACGGCCGTTTATTACTGTGCCCGCGAGCGACACTTGAACTCCCCGTCTGACGCTTTTGATCTCTGGGGCCAAGGGACAATGGTCATCGTCTCTTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV1-2*00(2427.1) | IGHD3-1600(40),IGHD3-1000(35) | IGHJ3*00(413) | nan | 57|347|373|0|290|SG65CSA124TSC139ASC145TSG148CST150CSC152GST153ASG158ASA184TSG188CST204ASG205ASC209GSA228TSA230CSA231GSA243GST255ASA264GSG272ASA285TSG286CSC287TSC292TSC303TSG307CSG311CSG314ASG316ASG335T|2001.0 | 11|19|111|306|314||40.0;8|15|93|306|313||35.0 | 20|70|70|317|367|ST23CSA33CSC58T|413.0 | nan | CAGGTGCACCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCATGGCTTCT | 40 | GGATACAACTTCATCGCCCAGAAT | 40 | ATACACTGGGTGCGACAGGCCCCTGGACTAGGCCTTGAGTGGATGGGAAAG | 40 | ATGAACCCTAACAGTGGTGGCTCC | 40 | GACTATGCACAGGAGTTTCAGGGCAGGGTCACCGTGACCAGAGACACGTCCATCTCTACAGTCTACATGGAGTTGACCAGCCTAAAATCTGACGACACGGCCGTTTATTAC | 40 | TGTGCCCGCGAGCGACACTTGAACTCCCCGTCTGACGCTTTTGATCTCTGG | 40 | GGCCAAGGGACAATGGTCATCGTCTCTTCAG | 40 | QVHLVQSGAEVKKPGASVKVSCMAS | GYNFIAQN | IHWVRQAPGLGLEWMGK | MNPNSGGS | DYAQEFQGRVTVTRDTSISTVYMELTSLKSDDTAVYY | CARERHLNSPSDAFDLW | GQGTMVIVSS_ | ::::0:75:99:150:174:285:-6:290:306:26:-55:314:317:0:336:367:: |
| 99 | 99 | 0.00166484 | CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGGGACCGTGTCCCTCACCTGCGCTGTGTCTGGTGTCTCCATAAGCAGTGATAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGCGCTGGAGTGGATTGGGGAAATCCATCATAGTGGGAGTACCAACTACAACCCTTCCCTCAAGAGTCGAGTCACCATGTCAGTTGTCCCGTCCAAGGACCTGTTCTCCCTGACCCTGAACTCTGTGACCGCCGCGGACACGGCCTTCTATTACTGTGCGAGAGATCAGGGCAGCCACCCCGGCGATTGGGGCCAGGGAACCCTGGTCTCCGTCTCCTCAG | IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIHIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII | IGHV4-4*00(2810.4) | IGHD6-1900(35),IGHD2-1500(31),IGHD5-12*00(30) | IGHJ400(311),IGHJ500(311) | nan | 57|355|373|0|298|SA94GSC108GSC128GSG136TSC143ASA150GSG151ASG190CST213CSC227TSG242TSA266GSA272TSA274TSA276CSA277CSA285GSA289TSA301CSG302CSG307ASG333TSG335C|2313.0 | 4|11|63|302|309||35.0;6|15|93|301|310|ST11C|31.0;8|14|69|303|309||30.0 | 34|68|68|318|352|SA55T|311.0;37|71|71|318|352|SA58T|311.0 | nan | CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGGGACCGTGTCCCTCACCTGCGCTGTGTCT | 40 | GGTGTCTCCATAAGCAGTGATAACTGG | 40 | TGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGCGCTGGAGTGGATTGGGGAA | 40 | ATCCATCATAGTGGGAGTACC | 40 | AACTACAACCCTTCCCTCAAGAGTCGAGTCACCATGTCAGTTGTCCCGTCCAAGGACCTGTTCTCCCTGACCCTGAACTCTGTGACCGCCGCGGACACGGCCTTCTATTAC | 39 | TGTGCGAGAGATCAGGGCAGCCACCCCGGCGATTGG | 39 | GGCCAGGGAACCCTGGTCTCCGTCTCCTCAG | 40 | QVQLQESGPGLVRPSGTVSLTCAVS | GVSISSDNW | WSWVRQPPGKALEWIGE | IHHSGST | NYNPSLKSRVTMSVVPSKDLFSLTLNSVTAADTAFYY | CARDQGSHPGDW | GQGTLVSVSS_ | ::::0:75:102:153:174:285:2:298:302:17:-31:309:318:-14:321:352:: |
Quality control
Now when we have processed all samples, we can proceed to quality control. First thing that we want to look at is the alignment quality. This can be easily done with the following command:
mixcr exportQc align results/*.clns figs/alignQc.pdf
From the plot above we see that most samples have high percentage of successfully aligned reads (above 90%). What we can also tell is that from all the samples those that come from HIP1_female_IgG4 have a lower alignment rate:
- SRR8365486_HIP1_female_IgG4
- SRR8365430_HIP1_female_IgG4
- SRR8365394_HIP1_female_IgG4
- SRR8365317_HIP1_female_IgG4
- SRR8365280_HIP1_female_IgG4
That suggest a potential issue during sample preparation. Note that HIP3_male_IgG4 and HIP3_male_IgG3 sample also tend to have a lower alignment rate.
Let's look at the same plot, but instead of percentages of reads we will plot an absolute number of reads.
mixcr exportQc align --absolute-values results/*.clns figs/alignQcAbsolute.pdf
The plot shows that nearly all bad samples have significantly lower total reads count. Next, lets take a closer look at SRR8365280_HIP1_female_IgG4. This sample has quite a bit of reads but most of them lack Ig sequences. By default, MiXCR removed non target reads during alignment. We will realign this sample using options -OallowPartialAlignments=true and -OallowNoCDR3PartAlignments=true to preserve partially aligned reads. We will also save not aligned reads (--not-aligned-R1, --not-aligned-R2) to separate FASTQ files for manual inspection. See mixcr align for more details.
Bellow is the complete command:
mkdir -p debug
mixcr align -f \
--species hsa \
-p generic-amplicon \
-OvParameters.geneFeatureToAlign="VTranscriptWithout5UTRWithP" \
-OvParameters.parameters.floatingLeftBound=true \
-OjParameters.parameters.floatingRightBound=false \
-OallowNoCDR3PartAlignments=true \
-OallowPartialAlignments=true \
--not-aligned-R1 debug/SRR8365280_HIP1_female_IgG4_notAligned_R1.fastq \
--not-aligned-R2 debug/SRR8365280_HIP1_female_IgG4_notAligned_R2.fastq \
-r debug/SRR8365280_HIP1_female_IgG4_debug.report \
raw/SRR8365280_HIP1_female_IgG4_R1.fastq.gz raw/SRR8365280_HIP1_female_IgG4_R2.fastq.gz \
debug/SRR8365280_HIP1_female_IgG4_debug.vdjca
Resulting SRR8365280_HIP1_female_IgG4_notAligned_R1.fastq and SRR8365280_HIP1_female_IgG4_notAligned_R1.fastq files can be manually inspected. A brief BLAST search revealed that a lot of reads align with PhiX, which is regularly used as a DNA sequencing control in Illumina protocol. Bellow you can see a few reads from SRR8365280_HIP1_female_IgG4_notAligned_R2.fastq.
@SRR8365280.116 GWZHISEQ01:570:HYJYKBCXX:1:1101:12039:44077/2
GAGAGATGAGATTGAGGCTGGGAAAAGTTACTGTAGCCGACGTTTTGGCGGCGCAACCTGTGACGACAAATCTGCTCAAATTTATGCGCGCTTCGATAAAAATGATTGGCGTATCCAACCTGCAGAGTTTTATCGCTTCCATGACGCAGAAGTTAACACTTTCGGATATTTCTGATGAGTCGAAAAATTATCTTGATAAAGCAGGAATTACTACTGCTTGTTTACGAATTAAATCGAAGTGGACTGCTGGC
+
DDBDD<GHHIFHIHIIIEHIGGIIIIIIGHIIIICHIIIIIHEHHHHDHIICHHHIIIIIIIIIIIGDHIIFHIIIIIGIIIIIHIHHIHIIHIIHHIIIIHIIIIIIIIIIIIIGIIIIHIIIIEHHIIHHHGIIIIIIIIIIIIIHIIIHIHHIIIIIIHIIIII=FHHIFHCGHG?HIIIIGIIIIEHCFHHII?GHH.FHEHIIHHHH-BGHHHHGFHIIIHI.5B6-8@F-B@HHHHIIIIGFE?-
@SRR8365280.117 GWZHISEQ01:570:HYJYKBCXX:1:1101:13143:44082/2
ACGATGAGGGACATAAAAAGTAAAAATGTCTACAGTAGAGTCAATAGCAAGGCCACGACGCAATGGAGAAAGACGGAGAGCGCCAACGGCGTCCATCTCGAAGGAGTCGCCAGCGATAACCGGAGTAGTTGAAATGGTAATAAGACGACCAATCTGACCAGCAAGGAAGCCAAGATGGGAAAGGTCATGCGGCATACGCTCGGCGCCAGTTTGAATATTAGACATAATTTATCCTCAAGTAAGGGGCCGAA
+
DDDDBIIIIIHHGHHIHHHIIIFIGIHHIIHHIIIIIHHIHIIIIEHHHGIIIIIIIIIHHIIIIIIHIIIFHIHIIIIIHGHIIIIHIIIIIHIHIIIIIDGHHHHIGIIHIIIIIIIIIGHIHGHHHHHIHIIEHIIII@HHIIIIIIIHIHIIHHIHIHIIIIIHIIII.BEGHGII?FHGHFHHHCDHIIIIHHCEHHIHIGIIIAHGEEEHH?FH?AFFHFHHHHH?FCH--BHHHHHE@,,>??H
@SRR8365280.118 GWZHISEQ01:570:HYJYKBCXX:1:1101:9938:44446/2
AGAAGAAAACGTGCGTCAAAAATTACGTGCAGAAGGAGTGATGTAATGTCTAAAGGTAAAAAACGTTCTGGCGCTCGCCCTGGTCGTCCGCAGCCGTTGCGAGGTACTAAAGGCAAGCGTAAAGGCGCTCGTCTTTGGTATGTAGGTGGTCAACAATTTTAATTGCAGGGGCTTCGGCCCCTTACTTGAGGATAAATTATGTCTAATATTCAAACTGGCGCCGAGCGTATGCCGCATGACCTTTCCCATCT
+
DDDDDIIGIIIIIIHGHHHHHHHIIIIHIF?HHIII?FHIIHIIIEHFHHIIIIIIIIHIIIIIIHIIIHIIIIIIIIIIIIIIIIIGIIIIIIIIHHHIHHHHIIIIHIIIIIIIHIIIHIIHIGIICGHCHHIHHGEEEEHIIIIIIIIIIIGHIIIIIIIIHIIICE<CHIIHHIIHIHIIIIFHIIIIIIHHEGEHHAFEECHIGHIIIIIG?E?EEH?CHGIGHII?GHIDDHHHIIIHEHEFB-A
Now lets look inside SRR8365280_HIP1_female_IgG4_debug.vdjca file witch now has partially aligned reads in it. That can be easily achieved using mixcr exportAlignmentsPretty.
The function bellow will generate a .txt human-readable file with alignments. We use parameter --skip 1000 to skip first 1000 reads, as first reads usually have bad quality, and --limit 100 will export only 100 alignments.
mixcr exportAlignmentsPretty
--skip 1000 \
--limit 100 \
debug/SRR8365280_HIP1_female_IgG4_debug.vdjca \
SRR8365280_HIP1_female_IgG4_debug.alignments.txt
Bellow you can see one of the alignments. First read aligns with a good score to IGHV1-69D. But its pair consists of low-quality nucleotides and can't be aligned against ahy IGHJ.
Further analysis might help reveal where such low quality reads come from.
>>> Read ids: 12846
L1><L2 L2><FR1
_ T R F L F V V A A A T G V Q S Q V Q L V Q S G P E V
Quality 76767888777877765777666775777788877737576737677788888767777778357777767777667877
Target0 0 CACTAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGCCTGAGGTGA 79 Score
IGHV1-69D*00 11 cTGGaggttcctctttgtggtggcagcagctacaggtgtccagtcccaggtgcagctggtgcagtctgggGctgaggtga 90 1901
FR1><CDR1 CDR1><FR2
K K P G S S V K V S C E A S G G T F S N F A V N W V R
Quality 87888877888677675673763577787777777786767777776667878888888773577677878867775677
Target0 80 AGAAGCCTGGGTCGTCGGTGAAGGTCTCCTGCGAGGCTTCTGGAGGCACCTTCAGTAACTTTGCTGTCAACTGGGTGCGA 159 Score
IGHV1-69D*00 91 agaagcctgggtcCtcggtgaaggtctcctgcAaggcttctggaggcaccttcagCaGctAtgctAtcaGctgggtgcga 170 1901
FR2><CDR2 CDR2><FR3
Q A P G Q G L E W V G G I I P L F N V A K Y A Q K F E
Quality 77787778865577867376625733535577887777787767786772253677767777677777787777766667
Target0 160 CAGGCCCCTGGACAAGGGCTTGAGTGGGTGGGAGGGATCATCCCTCTATTTAATGTGGCAAAGTACGCACAGAAGTTCGA 239 Score
IGHV1-69D*00 171 caggcccctggacaagggcttgagtggAtgggagggatcatccctAtCtttGGtACAgcaaaCtacgcacagaagttcCa 250 1901
G R V _
Quality 76677566676
Target0 240 GGGCAGAGTCA 250 Score
IGHV1-69D*00 251 gggcagagtca 261 1901
Quality 26426422222222222562442222424424255222225225222225224226522255252272242277525257
Target1 0 GGTTGGTTGGCGGGCTCATCCCGCTATTTAATGTGGGGATGTACGCACTGAGGTACGTTGGCAGGGTCCCGGTTGTCGCG 79 Score
Quality 72737277523535532353332333335333222235526353536262252522222577533555352225673735
Target1 80 GACGATTCAGTGGGCTGTGCTTACGTAGACATTGCCCGCTTGCGATCTGCCGCCAGCGCCGTGTATTACTGTGCGGCTTC 159 Score
Quality 53333223353333655367555355333325223333535353355335367777733353335333333533533533
Target1 160 AGGTGGCGACGTCCTGTGATATGACTACAAGGCCCCCTAAGGGGATGAACTATGGGGGCAATCGACAATAGTGACCGTCT 239 Score
Quality 33533233333
Target1 240 ACTAAGTTTCG 250 Score
Finally, lets check chain usage among all samples.
mixcr exportQc chainUsage results/*.clns figs/chainUsage.pdf
The plot suggests that this data has a low cross-contamination level, since almost all clones from IgG1, IgG2,IgG3,IgG4,IgM and IgA samples are IGH, and samples with IgK and IgL mostly consist of IGK and IGL clones.
Full-length clonotype assembly
ABhelix BCR protocol allows to recover a broader BCR receptor sequence then just CDR3 region. According to the protocol, forward primers are located in the leader region, thus we can safely use an assembling feature that starts from FR1 and be sure that no primers will affect the original sequence. The reverse primers are located in C gene region close to FR4End.
Taking into account what is mentioned above, the longest possible assembling feature for this protocol is "{FR1Begin:FR4End}".
MiXCR has a specific preset to obtain full-length BCR clones with ABhelix protocol:
mixcr analyze abhelix-human-bcr-full-length\
raw/SRR8365277_HIP1_female_IgG1_R1.fastq.gz \
raw/SRR8365277_HIP1_female_IgG1_R2.fastq.gz \
results/SRR8365277_HIP1_female_IgG1.vdjca
The mixcr assemble step in this preset differs from the one above in the following manner:
--8<-- "guides/abhelix-bcr/scripts/140-upstream-assemble-full-length.sh
-OassemblingFeatures="{FR1Begin:FR4End}"- sets the assembling feature to the region which starts from
FR1Beginand ends at the end ofFR4.
Notice that we do not use -OseparateByV=true and -OseparateByJ=true in this case because assembling feature already covers full V and J sequences, thus in case if clones have identical CDR3 they will still be separated.
Reports
Finally, MiXCR provides a very convenient way to look at the reports generated at ech step. Every .vdjca, .clns and .clna file holds all the reports for every MiXCR function that has been applied to this sample. E.g. in our case .clns file contains reports for mixcr align and mixcr assemble. To output this report use mixcr exportReports as shown bellow. Note --json parameter will output a JSON-formatted report.
mixcr exportReports \
results/SRR8365277_HIP1_female_IgG1.clns \
results/SRR8365277_HIP1_female_IgG1.report.txt
mixcr exportReports \
--json \
results/SRR8365277_HIP1_female_IgG1.clns \
results/SRR8365277_HIP1_female_IgG1.report.json
Show report file
============== Align Report ==============
Input file(s): /raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R1.fastq.gz,/raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R2.fastq.gz
Output file(s): results/SRR8365277_HIP1_female_IgG1.vdjca
Version: 4.0.0-306-develop; built=Fri Sep 23 00:05:26 CEST 2022; rev=f7972131fd; lib=repseqio.v2.0
Command line arguments: align --species hsa -n 100000 -p kAligner2_4.0 -OvParameters.geneFeatureToAlign=VTranscriptWithout5UTRWithP -OvParameters.parameters.floatingLeftBound=false -OjParameters.parameters.floatingRightBound=true --report results/SRR8365277_HIP1_female_IgG1.report.txt --json-report results/SRR8365277_HIP1_female_IgG1.report.json /raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R1.fastq.gz /raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R2.fastq.gz results/SRR8365277_HIP1_female_IgG1.vdjca
Analysis time: 0ns
Total sequencing reads: 100000
Successfully aligned reads: 96116 (96.12%)
Paired-end alignment conflicts eliminated: 4965 (4.96%)
Alignment failed, no hits (not TCR/IG?): 2056 (2.06%)
Alignment failed because of absence of V hits: 5 (0.01%)
Alignment failed because of absence of J hits: 1483 (1.48%)
No target with both V and J alignments: 340 (0.34%)
Overlapped: 93602 (93.6%)
Overlapped and aligned: 90679 (90.68%)
Alignment-aided overlaps: 1473 (1.62%)
Overlapped and not aligned: 2923 (2.92%)
No CDR3 parts alignments, percent of successfully aligned: 37 (0.04%)
Partial aligned reads, percent of successfully aligned: 840 (0.87%)
V gene chimeras: 93 (0.09%)
TRB chains: 1 (0%)
TRB non-functional: 0 (0%)
IGH chains: 96115 (100%)
IGH non-functional: 1190 (1.24%)
Realigned with forced non-floating bound: 15742 (15.74%)
Realigned with forced non-floating right bound in left read: 2751 (2.75%)
Realigned with forced non-floating left bound in right read: 2751 (2.75%)
============== Assemble Report ==============
Input file(s): results/SRR8365277_HIP1_female_IgG1.vdjca
Output file(s): results/SRR8365277_HIP1_female_IgG1.clns
Version: 4.0.0-306-develop; built=Fri Sep 23 00:05:26 CEST 2022; rev=f7972131fd; lib=repseqio.v2.0
Command line arguments: assemble -f -OassemblingFeatures={FR1Begin:FR4End} --report results/SRR8365277_HIP1_female_IgG1.report.txt --json-report results/SRR8365277_HIP1_female_IgG1.report.json results/SRR8365277_HIP1_female_IgG1.vdjca results/SRR8365277_HIP1_female_IgG1.clns
Analysis time: 0ns
Final clonotype count: 7035
Average number of reads per clonotype: 8.45
Reads used in clonotypes, percent of total: 59465 (59.47%)
Reads used in clonotypes before clustering, percent of total: 61595 (61.59%)
Number of reads used as a core, percent of used: 57233 (92.92%)
Mapped low quality reads, percent of used: 4362 (7.08%)
Reads clustered in PCR error correction, percent of used: 2130 (3.46%)
Reads pre-clustered due to the similar VJC-lists, percent of used: 0 (0%)
Reads dropped due to the lack of a clone sequence, percent of total: 17978 (17.98%)
Reads dropped due to a too short clonal sequence, percent of total: 0 (0%)
Reads dropped due to low quality, percent of total: 0 (0%)
Reads dropped due to failed mapping, percent of total: 16543 (16.54%)
Reads dropped with low quality clones, percent of total: 0 (0%)
Clonotypes eliminated by PCR error correction: 1682
Clonotypes dropped as low quality: 0
Clonotypes pre-clustered due to the similar VJC-lists: 0
IGH chains: 7035 (100%)
IGH non-functional: 65 (0.92%)
{
"type": "alignerReport",
"commandLine": "align --species hsa -n 100000 -p kAligner2_4.0 -OvParameters.geneFeatureToAlign=VTranscriptWithout5UTRWithP -OvParameters.parameters.floatingLeftBound=false -OjParameters.parameters.floatingRightBound=true --report results/SRR8365277_HIP1_female_IgG1.report.txt --json-report results/SRR8365277_HIP1_female_IgG1.report.json /raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R1.fastq.gz /raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R2.fastq.gz results/SRR8365277_HIP1_female_IgG1.vdjca",
"inputFiles": [
"/raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R1.fastq.gz",
"/raw/PRJNA511481-HIP/ABHelix_BCR/SRR8365277_HIP1_female_IgG1_R2.fastq.gz"
],
"outputFiles": [
"results/SRR8365277_HIP1_female_IgG1.vdjca"
],
"version": "4.0.0-306-develop; built=Fri Sep 23 00:05:26 CEST 2022; rev=f7972131fd; lib=repseqio.v2.0",
"trimmingReport": null,
"totalReadsProcessed": 100000,
"aligned": 96116,
"notAligned": 3884,
"notAlignedReasons": {
"NoCDR3Parts": 0,
"NoJHits": 1483,
"VAndJOnDifferentTargets": 340,
"NoHits": 2056,
"LowTotalScore": 0,
"NoVHits": 5,
"NoBarcode": 0
},
"chimeras": 0,
"overlapped": 93602,
"alignmentAidedOverlaps": 1473,
"overlappedAligned": 90679,
"overlappedNotAligned": 2923,
"pairedEndAlignmentConflicts": 4965,
"vChimeras": 93,
"jChimeras": 0,
"chainUsage": {
"type": "chainUsage",
"chimeras": 0,
"total": 96116,
"chains": {
"TRB": {
"total": 1,
"nonFunctional": 0,
"isOOF": 0,
"hasStops": 0
},
"IGH": {
"total": 96115,
"nonFunctional": 1190,
"isOOF": 653,
"hasStops": 537
}
}
},
"realignedWithForcedNonFloatingBound": 15742,
"realignedWithForcedNonFloatingRightBoundInLeftRead": 2751,
"realignedWithForcedNonFloatingLeftBoundInRightRead": 2751,
"noCDR3PartsAlignments": 37,
"partialAlignments": 840,
"tagReport": null
}
{
"type": "assemblerReport",
"commandLine": "assemble -f -OassemblingFeatures={FR1Begin:FR4End} --report results/SRR8365277_HIP1_female_IgG1.report.txt --json-report results/SRR8365277_HIP1_female_IgG1.report.json results/SRR8365277_HIP1_female_IgG1.vdjca results/SRR8365277_HIP1_female_IgG1.clns",
"inputFiles": [
"results/SRR8365277_HIP1_female_IgG1.vdjca"
],
"outputFiles": [
"results/SRR8365277_HIP1_female_IgG1.clns"
],
"version": "4.0.0-306-develop; built=Fri Sep 23 00:05:26 CEST 2022; rev=f7972131fd; lib=repseqio.v2.0",
"preCloneAssemblerReport": null,
"totalReadsProcessed": 100000,
"initialClonesCreated": 8717,
"readsDroppedNoTargetSequence": 17978,
"readsDroppedTooShortClonalSequence": 0,
"readsDroppedLowQuality": 0,
"coreReads": 57233,
"readsDroppedFailedMapping": 16543,
"lowQualityRescued": 4362,
"clonesClustered": 1682,
"readsClustered": 2130,
"clones": 7035,
"clonesDroppedAsLowQuality": 0,
"clonesPreClustered": 0,
"readsPreClustered": 0,
"readsInClones": 59465,
"readsInClonesBeforeClustering": 61595,
"readsDroppedWithLowQualityClones": 0,
"clonalChainUsage": {
"type": "chainUsage",
"chimeras": 0,
"total": 7035,
"chains": {
"IGH": {
"total": 7035,
"nonFunctional": 65,
"isOOF": 55,
"hasStops": 10
}
}
}
}